2004
DOI: 10.1089/089771504322778622
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Abstract: Embryonic stem (ES) cells have been investigated in various animal models of neurodegenerative disease; however, few studies have examined the ability of ES cells to improve functional outcome following traumatic brain injury (TBI). The purpose of the present study was to examine the ability of pre-differentiated murine ES cells (neuronal and glial precursors) to improve functional outcome. Rats were prepared with a unilateral controlled cortical impact injury or sham and then transplanted 7 days later with 10… Show more

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Cited by 84 publications
(68 citation statements)
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“…Murine ES cells (D3, ATCC) were transfected in the presence of FuGENE 6 (Roche) to express green fluorescent protein (GFP) [10,13,22,23]. Transfected colonies were selected as described previously [13] (see Fig.…”
Section: Cell Culture and Differentiationmentioning
confidence: 99%
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“…Murine ES cells (D3, ATCC) were transfected in the presence of FuGENE 6 (Roche) to express green fluorescent protein (GFP) [10,13,22,23]. Transfected colonies were selected as described previously [13] (see Fig.…”
Section: Cell Culture and Differentiationmentioning
confidence: 99%
“…A standard CCI model was used in this experiment that produced a moderate injury [13]. Subjects were anesthetized with a ketamine (90 mg/kg, i.p.)…”
Section: Surgerymentioning
confidence: 99%
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