Transplantation of human pluripotent stem cells overexpressing insulin/ERRγ can efficiently decrease the HbA1c levels of type 2 diabetes patient (Case #2-A)

Wang, T; Chen, X; Cui, Xiaowei; Zhao, Luping; Zhou, Yang; Wang, X; Zhang, B; Fan, Min; Shi, Xun; R, Li; Fang, Qin; Diao, Xianmin; Zhang, L; Gao, Yang; Meng, Ying; Fan, Songqing; An, Liguo; Zhang, G

doi:10.1101/462127

Cited by 2 publications

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“…All these stem cells were isolated and proliferated with the written confirmed consent of the participants, and all the culture, proliferation, transduction and preparation procedures of the stem cells were exactly the same as previously described. [3][4][5] Patient's treatment and results…”

Section: Statement Of Ethical Approvalmentioning

confidence: 99%

“…H-P L, female, aged 64, the stem cell transplantation and comparison of her T2D symptoms before and after the stem cell transplantation therapy was listed in Table 8 & Table 9. [3][4][5] These results demonstrated that, after totally 16 times of stem cell transplantations of dgHPSCs overexpressing human INS or ERRγ genes, and human GLP-1(7-36) gene (Table 8), respectively, the patient's F-GLU levels decreased significantly from 18.88mmol/L down to 4.12mmol/L, and the F-INS secretion increased slightly from 22.89µU/mL to 23.95µU/mL (Table 9). These data suggested that our treatment method was efficient for the patient.…”

Section: Patient Case #6mentioning

confidence: 99%

“…6 Sequencing of the naturally occurring peptides extracted from human gut revealed that the structure of native GLP-1 corresponds to PG 78-107 amino acid sequence, and this truncated peptide, designated as GLP-1 , was found to be a potent stimulator of GLU-induced INS secretion, whereas, the full-length GLP-1 was inactive. [6][7][8] During the past year, besides these two reported T2D patients, [3][4][5] we also treated many other T2D patients with similar strategies. All the treatments are similar with our reports earlier.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Recently, in two T2D patients, we reported that transplantation of dgHPSCs overexpressing human INS and/or ERRγ genes could efficiently decrease the patient's blood GLU levels, improve the secretion of C-P, and reverse the diabetes complications, which brings the promising expectations for completely cure human T1D and T2D. [3][4][5] GLP-1 is a 30-amino acid peptide hormone produced in the intestinal epithelial endocrine L-cells by differential processing of proglucagon (PG) gene. 6 The main actions of GLP-1 are to stimulate INS secretion, to inhibit glucagon secretion.…”

Section: Introductionmentioning

confidence: 99%

“…All the treatments are similar with our reports earlier. [3][4][5] The dgHPSCs numbers per transplantation are around 1 X 10 8 cells, overexpressing human INS and/or ERRγ, and human GLP-1 (7-36) genes, individually or simultaneously. [3][4][5] Taken together, our reports are the first in the world to predict that human diabetes might be completely cured eventually via stem cell transplantation therapy.…”

Section: Introductionmentioning

confidence: 99%

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Efficient treatment of seven type 2 diabetes patients with human pluripotent stem cell transplantations overexpressing human insulin and/or ERRγ and GLP-1 genes

Wang¹

2019

ATROA

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Although daily injection of insulin (INS) is a common treatment for human diabetes, exogenous INS administration has little function to prevent the development of diabetes complications. Previously, we investigated the efficacies of transplantation of directly-generated human pluripotent stem cells (dgHPSCs) overexpressing human INS and/or estrogen-related receptor γ (ERRγ) genes for the treatment of human diabetes patients. In this study, we treated other seven human type 2 diabetes (T2D) cases with transplantation of dgHPSCs overexpressing INS, ERRγ and glucagonlike peptide 1 (GLP-1) genes. Our data proved that this strategy can increase the secretion of C-peptide (C-P), decrease the patient's glucose (GLU) and HbA1c levels efficiently. To date, we treated 20 human T2D patients with our invented strategies. Thus, our method might lay a very important foundation for the eventually cure of human diabetes.

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Section: Statement Of Ethical Approvalmentioning

confidence: 99%

Section: Patient Case #6mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficient treatment of seven type 2 diabetes patients with human pluripotent stem cell transplantations overexpressing human insulin and/or ERRγ and GLP-1 genes

Wang¹

2019

ATROA

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Transplantation of Human dgHPSCs Overexpressing Insulin and ERRγ can Efficiently Decrease the Glucose and HbA1c levels, Increase the Secretion of C-peptide and Repair the Complications of Coronary Heart Disease in T2D Patient (Case #1-A)

Wang¹,

Wang²,

Zhang³

et al. 2018

Stem Cells Regen Med

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Daily injection of insulin is a widely used treatment for human diabetes. Yet, exogenous insulin injection cannot efficiently prevent the development of diabetes complications. Recently, we reported that the transplantation of directly-generated human pluripotent stem cells (dgHPSCs) overexpressing human insulin or estrogen-related receptor γ (ERRγ) gene can not only reduce the glucose levels of human diabetes patients, but also restore the function of human pancreatic β cells, and therefore with the potential to prevent the patients from developing diabetic complications. Here, we further reported that transplantation of dgHPSCs overexpressing insulin (INS) and ERRγ genes can significantly decrease the glucose and HbA1c levels and increase the secretion of C-peptide and repair the complication of coronary heart disease in type 2 diabetes (T2D) patient. Our data proved that this strategy can secrete high level insulin in vitro, increase the secretion of C-peptide (C-P) in vivo, decrease the patient's glucose (GLU) and HbA1c levels, and repair the patient's diabetic complications efficiently. Thus, our report is the first to prevent and reverse human diabetic complications and with the potential to completely cure human T2D.

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Transplantation of human pluripotent stem cells overexpressing insulin/ERRγ can efficiently decrease the HbA1c levels of type 2 diabetes patient (Case #2-A)

Cited by 2 publications

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Efficient treatment of seven type 2 diabetes patients with human pluripotent stem cell transplantations overexpressing human insulin and/or ERRγ and GLP-1 genes

Efficient treatment of seven type 2 diabetes patients with human pluripotent stem cell transplantations overexpressing human insulin and/or ERRγ and GLP-1 genes

Transplantation of Human dgHPSCs Overexpressing Insulin and ERRγ can Efficiently Decrease the Glucose and HbA1c levels, Increase the Secretion of C-peptide and Repair the Complications of Coronary Heart Disease in T2D Patient (Case #1-A)

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