Transplantation of Human Amnion Epithelial Cells Improves Endometrial Regeneration in Rat Model of Intrauterine Adhesions

Ouyang, Xiaolan; You, Shuang; Zhang, Yulin; Zhang, Chanyu; Zhang, Guanghui; Shao, Xiaoyan; He, Fan; Hu, Lina

doi:10.1089/scd.2019.0246

Cited by 29 publications

(19 citation statements)

References 83 publications

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“…In addition, both hAMSCs and hAESCs have considerable potential for treatment of other gynecological diseases. Studies shown that both hAMSCs and hAESCs effectively treated intrauterine adhesion and promoted endometrial regeneration through paracrine effects [86][87][88]. Motedayyen et al observed that hAESCs were able to treat unexplained recurrent spontaneous abortion through rescuing maternal immune abnormalities, inhibiting the activation of T cells and reducing the production of the activated proinflammatory cytokines [89].…”

Section: Gynecological Diseasesmentioning

confidence: 99%

Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells

Liu

Huang

et al. 2021

IJMS

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Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and improve functional recovery in experimental model and clinical trials. However, there are still many limitations and unresolved problems regarding stem cell therapy in terms of ethical barriers, immune rejection, tumorigenicity, and cell sources. By reviewing recent literatures and our related works, human amnion-derived stem cells (hADSCs) including human amniotic mesenchymal stem cells (hAMSCs) and human amniotic epithelial stem cells (hAESCs) have shown considerable advantages over other stem cells. In this review, we first described the biological characteristics and advantages of hADSCs, especially for their high pluripotency and immunomodulatory effects. Then, we summarized the therapeutic applications and recent progresses of hADSCs in treating various diseases for preclinical research and clinical trials. In addition, the possible mechanisms and the challenges of hADSCs applications have been also discussed. Finally, we highlighted the properties of hADSCs as a promising source of stem cells for cell therapy and regenerative medicine and pointed out the perspectives for the directions of hADSCs applications clinically.

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Section: Gynecological Diseasesmentioning

confidence: 99%

Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells

Liu

Huang

et al. 2021

IJMS

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“…Currently, the majority of research exploring stem cells in unexplained infertility, RRF, or endometrial regenerative medicine is mainly restricted to non-endometrial stem cells [ 62 ]. This primarily includes MSCs derived from the bone marrow [ 67 , 68 , 157 , 158 ], umbilical cord [ 140 , 159 , 160 , 161 ], placenta [ 162 , 163 , 164 , 165 , 166 ], or adipose tissue [ 167 , 168 , 169 , 170 ]. Very limited data exists on eMSCs and their relationship to RRF, with no current evidence for the role of human epithelial eSPCs in this devastating condition.…”

Section: Avenues For Future Researchmentioning

confidence: 99%

The Role of Endometrial Stem/Progenitor Cells in Recurrent Reproductive Failure

Al-Lamee

Hill

Turner

et al. 2022

JPM

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Recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL), collectively referred to as recurrent reproductive failure (RRF), are both challenging conditions with many unanswered questions relating to causes and management options. Both conditions are proposed to be related to an aberrant endometrial microenvironment, with different proposed aetiologies related to a restrictive or permissive endometrium for an invading embryo. The impressive regenerative capacity of the human endometrium has been well-established and has led to the isolation and characterisation of several subtypes of endometrial stem/progenitor cells (eSPCs). eSPCs are known to be involved in the pathogenesis of endometrium-related disorders (such as endometriosis) and have been proposed to be implicated in the pathogenesis of RRF. This review appraises the current knowledge of eSPCs, and their involvement in RRF, highlighting the considerable unknown aspects in this field, and providing avenues for future research to facilitate much-needed advances in the diagnosis and management of millions of women suffering with RRF.

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“…Indeed, administration of mesenchymal stem cells (MSCs) derived from the umbilical cord increased glandular count, reduced endometrial fibrosis, and promoted cell proliferation in an AS murine model (Tang et al, 2016;Zhang et al, 2018). Further, MSCs derived from the amnion restored endometrial injury by reducing fibrosis, improving endometrial morphology (Ouyang et al, 2020), and exerting immunomodulatory properties (Gan et al, 2017). MSCs obtained from adipose tissue also restored endometrial tissue via increased vascularization and decreased fibrotic area in a murine model (Kilic et al, 2014), as did those obtained from menstrual blood.…”

Section: Stem Cell-based Therapymentioning

confidence: 99%

Strategies for managing Asherman's syndrome and endometrial atrophy: Since the classical experimental models to the new bioengineering approach

Miguel-Gómez

Romeu

Pellicer

et al. 2021

Molecular Reproduction Devel

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Endometrial function is essential for embryo implantation and pregnancy, but managing endometrial thickness that is too thin to support pregnancy or an endometrium of compromised functionality due to intrauterine adhesions is an ongoing challenge in reproductive medicine. Here, we review current and emerging therapeutic and experimental options for endometrial regeneration with a focus on animal models used to study solutions for Asherman's syndrome and endometrial atrophy, which both involve a damaged endometrium. A review of existing literature was performed that confirmed the lack of consensus on endometrial therapeutic options, though promising new alternatives have emerged in recent years (platelet-rich plasma, exosomes derived from stem cells, bioengineering-based techniques, endometrial organoids, among others). In the future, basic research using established experimental models of endometrial pathologies (combined with new high-tech solutions) and human clinical trials with large population sizes are needed to evaluate these emerging and new endometrial therapies.

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Transplantation of Human Amnion Epithelial Cells Improves Endometrial Regeneration in Rat Model of Intrauterine Adhesions

Cited by 29 publications

References 83 publications

Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells

Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells

The Role of Endometrial Stem/Progenitor Cells in Recurrent Reproductive Failure

Strategies for managing Asherman's syndrome and endometrial atrophy: Since the classical experimental models to the new bioengineering approach

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