Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with recurrent indolent non-Hodgkin's lymphoma

Vose, Julie M.; Bierman, Philip J.; Lynch, James C.; Atkinson, K; Juttner, Christopher A.; Hanania, Elie G.; Bociek, Gregory; Armitage, Jamés O.

doi:10.1053/bbmt.2001.v7.pm11787531

Cited by 59 publications

(44 citation statements)

References 25 publications

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“…+ cells provided longterm engraftment while being purged of unwanted cancer or T cells (Michallet et al 2000;Negrin et al 2000;Vose et al 2001). All of these data combined support the idea that HSCs are contained in the Lin…”

Section: Cd90mentioning

confidence: 99%

Establishment of a Normal Hematopoietic and Leukemia Stem Cell Hierarchy

Chao¹,

Seita²,

Weissman³

2008

Cold Spring Harbor Symposia on Quantitative Biology

116

108

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Many types of adult tissues, especially for high turnover tissues such as the blood and intestinal system, stand on a hierarchical tissue-specific stem cell system. Tissue-specific stem cells concurrently have self-renewal capacity and potential to give rise to all types of mature cells in their tissue. The differentiation process of the tissue-specific stem cell is successive restriction of these capacities. The first progeny of tissue-specific stem cells are multipotent progenitors (MPPs) that lose long-term self-renewal capacity yet have full lineage potential. MPPs in turn give rise to oligopotent progenitors, which then commit into lineage-restricted progenitors. This hierarchical system enables a lifelong supply of matured functional cells that generally have a short life span and a relatively high turnover rate. In this chapter, we review our findings and other key experiments that have led to the establishment of the current cellular stem and progenitor hierarchy in the blood-forming systems of mice and humans for both normal and leukemic hematopoiesis. We also review select signaling pathways intrinsic to normal hematopoietic and leukemic stem cell populations as well our recent findings elucidating the possible origin of the leukemia stem cell.

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Section: Cd90mentioning

confidence: 99%

Establishment of a Normal Hematopoietic and Leukemia Stem Cell Hierarchy

Chao¹,

Seita²,

Weissman³

2008

Cold Spring Harbor Symposia on Quantitative Biology

116

108

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“…Additional studies have demonstrated that human HSC also express CD90 (3)(4)(5). Perhaps the best demonstration of HSC function comes from human clinical trials of autologous mobilized peripheral blood in clinical transplantation, where long-term engraftment was provided by transplantation of purified CD34ϩCD90ϩ cells (6)(7)(8). In multiple reports (12)(13)(14), a common phenotype for AML LSC has been identified and found to be negative for expression of lineage markers (Lin-), positive for expression of CD34, and negative for expression of CD38 (9 -11).…”

mentioning

confidence: 99%

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

Majeti

Becker

Tian

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

253

246

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We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of LSC, we identified 3,005 differentially expressed genes. Using 2 independent analyses, we identified multiple pathways that are aberrantly regulated in leukemic stem cells compared with normal HSC. Several pathways, including Wnt signaling, MAP Kinase signaling, and Adherens Junction, are well known for their role in cancer development and stem cell biology. Other pathways have not been previously implicated in the regulation of cancer stem cell functions, including Ribosome and T Cell Receptor Signaling pathway. This study demonstrates that combining global gene expression analysis with detailed annotated pathway resources applied to highly enriched normal and malignant stem cell populations, can yield an understanding of the critical pathways regulating cancer stem cells.

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“…CD34 enrichment yields a population of cells enriched for HSC and blood progenitor cells, but still contains many other cell types. However, limited trials in which highly FACSpurified CD34 pos CD90 pos H S C s w e r e u s e d a s a s o u r c e o f r e c o n s t i t u t i n g c e l l s h a v e demonstrated that rapid reconstitution of the blood system can reliably be obtained using only HSCs (Negrin et al, 2000;Vose et al, 2001). …”

Section: Haematopoietic Stem Cell Markersmentioning

confidence: 99%

Stem Cell Characterization

Zaminy¹

2012

Flow Cytometry - Recent Perspectives

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Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with recurrent indolent non-Hodgkin's lymphoma

Cited by 59 publications

References 25 publications

Establishment of a Normal Hematopoietic and Leukemia Stem Cell Hierarchy

Establishment of a Normal Hematopoietic and Leukemia Stem Cell Hierarchy

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

Stem Cell Characterization

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