Transplantation of hematopoietic tissues into the circulating blood I. Experiments with lymph nodes in normal rabbits

Osogoe, Bunsuke

doi:10.1002/ar.1091070210

Cited by 32 publications

(14 citation statements)

References 18 publications

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“…A similar conclusion was reached by Ozogoe from experiments in rabbits also injected with homologous lymphoid cells (16). The failure of infiltrates to appear when disrupted cells were injected, or when cells from x-irradiated or thymectomized donors were employed, is admittedly presumptive evidence.…”

Section: Discussionsupporting

confidence: 59%

An Assay of Graft-Host Interactions Across Strong and Weak Histocompatibility Barriers in Mice

Miller

Pierce

Martínez

et al. 1963

The Journal of Experimental Medicine

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1. A new assay of graft-host interactions has been presented. It consists of the early finding of liver infiltrates in responsive and unresponsive homologous recipients 1 to 3 days after the intravenous injection of competent lymphoid tissue in the mouse. 2. Evidence is presented that infiltrates are of donor origin, and are influenced by a homologous antigenic environment. They can be quantitatively increased by preimmunization of donor to recipient and decreased by preimmunization of recipient to donor. Furthermore, they are present in lethally x-irradiated or neonatally thymectomized unresponsive recipients after intravenous injection of competent homologous spleen cells. 3. Splenomegaly, which also occurs in this early period, is a product of both donor and host-specific immune reactivity together with a small non-specific component of host reactivity. 4. A comparison, of the responsiveness of lymphoid tissue from different strains to the same transplantation antigens is presented, together with the observation of differences in the reactivity of reciprocal donor-recipient injection combinations to each other. 5. Graft-host interactions with this model can be demonstrated in donor-host strain combinations isogenic at the H-2 locus without preimmunization of the donor. Differences in reactivity of reciprocal donor-recipient combinations of lymphoid tissue injections to each other can be detected in this group as well as in the groups differing at the strong H-2 locus.

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Section: Discussionsupporting

confidence: 59%

An Assay of Graft-Host Interactions Across Strong and Weak Histocompatibility Barriers in Mice

Miller

Pierce

Martínez

et al. 1963

The Journal of Experimental Medicine

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“…Similar infiltrates have been described by Gorer and Boyse, following injection of parental cells into F1 recipients (2). The differences in the fate of injected lymphocytes in the liver and those in spleen have been observed by Osogoe (12) who found periportal accumulations of lymphocytes in the liver of rabbits persisting long after they had disappeared from the spleen. Fichtelins (13), whose results complement those of Osogoe, reported that 24 hours after transfusion of P32-1abeled lymphocytes, activity from injected lymphocytes could be found in the spleen and liver after syngenesiotransfusion (rat-to-rat, the same litter) but only in the liver after heterotransfusion (rabbit-to-rat).…”

Section: Discussionmentioning

confidence: 66%

The Differing Survival of Normal and Sensitized Spleen Cells Transferred to Allogeneic Hosts

Hattler

Schlesinger

Amos

1964

The Journal of Experimental Medicine

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Normal and isoimmune C3H and C57BL spleen cells were transferred intravenously into normal and irradiated allogeneic recipients and the fate of the donor cells determined by differential cytotoxicity and radioautographic techniques. It was found that spleen cells sensitized against their prospective recipients could be identified in the host's spleen for 1 day, whereas normal donor cells survived 2 to 3 days. Spleen cells presensitized with an indifferent antigen had survival times similar to normal donor cells. Irradiation of the recipients prior to cell transfer eliminated any difference in survival times between normal and presensitized donor cells in allogeneic hosts. It is concluded that the host plays an important role in the rapid destruction of spleen cells presensitized against host antigens. Experiments in which sensitized and normal C57BL spleen cells were mixed and transferred into normal C3H mice indicated that as little as 5 to 10 per cent of the donor cell population need be sensitized for the entire mixture to behave as if it were obtained from a sensitized animal, as shown by its elimination in the 1-day interval.

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“…One of the present authors, Osogoe, previously reported an observation that the number of megakaryocytes that contain one or more engulfed blood corpuscles is markedly increased after lymphocyte transfusion as well as after an injection of desoxyribonucleic acid (Osogoe, 1944(Osogoe, , 1950. Our further investigation has however revealed that the phenomenon is subject to a considerable individual variation.…”

mentioning

confidence: 55%

“…For transfusion of lymphocytes, the same procedure was employed as described in the previous paper by Osogoe (1950). The lymphocytes to be transfused were collected from the thymuses of 3 or 4 young rabbits weighing about 1.4 kg.…”

Section: Methodsmentioning

confidence: 99%

Variation in the Phagocytic Activity of Megakaryocytes

Osogoe

Ikeda

Ito

1955

Okajimas Folia Anatomica Japonica

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Transplantation of hematopoietic tissues into the circulating blood I. Experiments with lymph nodes in normal rabbits

Cited by 32 publications

References 18 publications

An Assay of Graft-Host Interactions Across Strong and Weak Histocompatibility Barriers in Mice

An Assay of Graft-Host Interactions Across Strong and Weak Histocompatibility Barriers in Mice

The Differing Survival of Normal and Sensitized Spleen Cells Transferred to Allogeneic Hosts

Variation in the Phagocytic Activity of Megakaryocytes

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