Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse

Arnhold, Stefan; Absenger, Yvonne; Klein, Helmut W.; Addicks, Klaus; Schraermeyer, Ulrich

doi:10.1007/s00417-006-0382-7

Cited by 126 publications

(79 citation statements)

References 32 publications

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“…The finding of MSCderived cells that express some of the features of neural retina cells progeny after transplantation raises some possibility that aspects of cell replacement can occur and play a role in BMSC-mediated rescue of vision [58,59]. Some studies indicate that rescue is due to retinal integration and neural differentiation of BMSCs to replace outer retinal cells [60][61][62], whereas others indicate that non-neural cells, such as MSC mediate rescue of the photoreceptor cell layer is due to improved circulation and secretion of growth factors essential for photoreceptor cell survival [59,63].…”

Section: Non-neural Stem Cellsmentioning

confidence: 99%

Stem Cells for Retinal Replacement Therapy

Stern

Temple

2011

Neurotherapeutics

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Retinal degenerative disease has limited therapeutic options and the possibility of stem cell-mediated regenerative treatments is being actively explored for these blinding retinal conditions. The relative accessibility of this central nervous system tissue and the ability to visually monitor changes after transplantation make the retina and adjacent retinal pigment epithelium prime targets for pioneering stem cell therapeutics. Prior work conducted for several decades indicated the promise of cell transplantation for retinal disease, and new strategies that combine these established surgical approaches with stem cell-derived donor cells is ongoing. A variety of tissue-specific and pluripotent-derived donor cells are being advanced to replace lost or damaged retinal cells and/or to slow the disease processes by providing neuroprotective factors, with the ultimate aim of long-term improvement in visual function. Clinical trials are in the early stages, and data on safety and efficacy are widely anticipated. Positive outcomes from these stem cell-based clinical studies would radically change the way that blinding disorders are approached in the clinic.

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Section: Non-neural Stem Cellsmentioning

confidence: 99%

Stem Cells for Retinal Replacement Therapy

Stern

Temple

2011

Neurotherapeutics

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“…Arnhold et al [149] found that the cones cannot survive without healthy rod cells. Therefore, it is difficult to achieve the aim of the treatment by simply transplanting the induced iPS cells into the retina of patients with retinitis pigmentosa because the rod cells will eventually die.…”

Section: Progress In the Research Of Stem Cell Therapy For Corneal DImentioning

confidence: 99%

Importance of the stem cell microenvironment for ophthalmological cell-based therapy

Park

Wang

2015

WJSC

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Cell therapy is a promising treatment for diseases that are caused by cell degeneration or death. The cells for clinical transplantation are usually obtained by culturing healthy allogeneic or exogenous tissue in vitro . However, for diseases of the eye, obtaining the adequate number of cells for clinical transplantation is difficult due to the small size of tissue donors and the frequent needs of long-term amplification of cells in vitro , which results in low cell viability after transplantation. In addition, the transplanted cells often develop fibrosis or degrade and have very low survival. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPS) are also promising candidates for cell therapy. Unfortunately, the differentiation of ESCs can bring immune rejection, tumorigenicity and undesired differentiated cells, limiting its clinical application. Although iPS cells can avoid the risk of immune rejection caused by ES cell differentiation post-transplantation, the low conversion rate, the risk of tumor formation and the potentially unpredictable biological changes that could occur through genetic manipulation hinder its clinical application. Thus, the desired clinical effect of cell therapy is impaired by these factors. Recent research findings recognize that the reason for low survival of the implanted cells not only depends on the seeded cells, but also on the cell microenvironment, which determines the cell survival, proliferation and even reverse differentiation. When used for cell therapy, the transplanted cells need a specific three-dimensional structure to anchor and specific extra cellular matrix components in addition to relevant cytokine signaling to transfer the required information to support their growth. These structures present in the matrix in which the stem cells reside are known as the stem cell microenvironment. The microenvironment interaction with the stem cells provides the necessary homeostasis for cell maintenance and growth. A large number of studies suggest that to explore how to reconstruct the stem cell microenvironment and strengthen its combination with the transplanted cells are key steps to successful cell therapy. In this review, we will describe the interactions of the stem cell microenvironment with the stem cells, discuss the importance of the stem cell microenvironment for cell-based therapy in ocular diseases, and introduce the progress of stem cell-based 448March 26, 2015|Volume 7|Issue 2|

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“…The first two are local and have their benefits and drawbacks: Particularly subretinal injection provides direct contact between BMSC, RPE layer and photoreceptors, but it is difficult to perform and risky.During degeneration Muller glial seal occupies the area and may prevent cell implantation and incorporation (Kicic et al, 2003;Arnhold et al, 2007;Inoue et al, 2007;Gong et al, 2008). Intravitreal injection is easy to perform, less risky, but it doesn't provide close contact with retinal and transplanted cells (Castanheira et al, 2008;Hill et al, 2009;Li et al, 2009;Wang et al, 2010a;Tsuruma et al, 2014).…”

Section: Retinitis Pigmentosamentioning

confidence: 99%

Mesenchymal Stem Cell Transplantation for Retinal Degenerations and Dystrophies: Present and Future

Ghazaryan¹,

Wang²,

Zhang³

et al. 2014

American Journal of Biochemistry and Biotechnology

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Retinal degenerations are the main causes of irreversible blindness in developed countries. Up to date the main pathological mechanisms of these diseases are not fully understood and consequently there is no complete treatment option for those diseases. In this aspect stem cells have drawn attention of many researchers and health care professionals. Considering ethical issues, safety and facile isolation Mesenchymal Stem Cells (MSCs) are more preferable for practical use. They have been used for several preclinical and clinical trials. In general the results were promising, however broader practical use should be preceded by resolving many problems and questions. In this review we will describe mesenchymal stem cells, especially those derived from Bone-Marrow (BMSC), their main features, privilege, mechanisms of action and their potential use for the treatment of retinal degenerations. We will also discuss the results of several pre-clinical and clinical trials.

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Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse

Abstract: Our data indicate that mesenchymal stem cells can prolong photoreceptor survival in the rhodopsin knockout mouse, also providing evidence of a therapeutical benefit in retinitis pigmentosa.

Cited by 126 publications

References 32 publications

Stem Cells for Retinal Replacement Therapy

Stem Cells for Retinal Replacement Therapy

Importance of the stem cell microenvironment for ophthalmological cell-based therapy

Mesenchymal Stem Cell Transplantation for Retinal Degenerations and Dystrophies: Present and Future

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