Transplantation of bone-marrow cells and fetal thymus in an infant with lymphopenic immunological deficiency

Koning, J. de; Dooren, L. J.; Bekkum, D. W. van; Rood, JJ van; Ka, Dicke; Rádl, J.

doi:10.1097/00007890-197001000-00007

Cited by 12 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,2 The advent of bone marrow transplantation (BMT) showed that these HSCs could sustain donor-derived hematopoiesis for life in both mice and humans. 1,[3][4][5] The development of in vitro culture technologies subsequently suggested that HSCs commit to downstream myeloerythroid fates through a stepwise progression of lineage-restricted progenitor cells. [6][7][8][9] The lineage relationships suggested by the studies of Metcalf and colleagues have recently been solidified through the prospective isolation of lineage-restricted progenitors at each of the major branch points of the hematopoietic hierarchy.…”

Section: Introductionmentioning

confidence: 99%

Zebrafish kidney stromal cell lines support multilineage hematopoiesis

Stachura

Reyes

Bartůněk

et al. 2009

Blood

108

View full text Add to dashboard Cite

Studies of zebrafish hematopoiesis have been largely performed using mutagenesis approaches and retrospective analyses based upon gene expression patterns in whole embryos. We previously developed transplantation assays to test the repopulation potentials of candidate hematopoietic progenitor cells. We have been impaired, however, in determining cellular differentiation potentials by a lack of short-term functional assays. To enable more precise analyses of hematopoietic progenitor cells, we

show abstract

Section: Introductionmentioning

confidence: 99%

Zebrafish kidney stromal cell lines support multilineage hematopoiesis

Stachura

Reyes

Bartůněk

et al. 2009

Blood

108

View full text Add to dashboard Cite

show abstract

“…1 Till January 2008, 727 allogeneic haematopoietic stem cell transplantations (HSCT) in 652 children have been performed in our unit. Our overall survival rate at 2 years post transplant is currently 65.4% (unpublished data).…”

Section: Introductionmentioning

confidence: 99%

High burden of late effects after haematopoietic stem cell transplantation in childhood: a single-centre study

Bresters

Gils

Kollen

et al. 2009

Bone Marrow Transplant

View full text Add to dashboard Cite

The aim of our study was to assess the cumulative incidence and severity ('burden') of late effects in a single-centre cohort of childhood haematopoietic stem cell transplantation (HSCT) survivors, at least 2 years after transplantation. The presence and severity of late effects in each survivor was documented according to the Common Terminology Criteria for Adverse Events (version 3.0). The burden of late effects was graded from mild to disabling/life-threatening. Risk factors for a high burden of late effects were assessed by univariate and multivariate logistic regression analyses. Among 162 survivors of HSCT seen in our late effects outpatient clinic, cumulative incidence of late effects was 93.2% after a median followup time of 7.2 years (range 2.0-21.0 years) after HSCT. The burden of late effects was mild, moderate, severe and disabling in 28, 41, 24 and 1% of survivors respectively. Risk factors for a severe or disabling burden of late effects were older age at HSCT (P for trend o0.001) and a conditioning regimen including irradiation OR 2.2, 95% CI 1.1-4.7, P ¼ 0.03). In conclusion, a high burden of late effects is found in childhood HSCT survivors after a median follow-up of only 7 years.

show abstract

“…7 Nine of the 55 responding centres (17%) started transplantation procedures before 1980, the majority, ie 40/55 (75%), started between 1980 and 1992, while 4/55 centres (8%) started only after 1992. Two centres did not specify the onset of their activity.…”

Section: Transplantation Activitymentioning

confidence: 99%

Transplantation activities and treatment strategies in paediatric stem cell transplantation centres: a report from the EBMT Working Party on Paediatric Diseases

Peters

Ladenstein

Minkov

et al. 1998

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:To determine the current approach to stem cell transplantation (SCT) in centres which treat predominantly paediatric patients, a questionnaire was sent to 67 centres known by the EBMT registry to perform SCT mainly in children. Fifty-five centres from 19 countries responded. Forty centres (75%) started their transplantation activities between 1980 and 1992. Median number of transplants/centre was 95 (range 8-400). Median number of transplants/centre/year was 18 (range 5-85). On average, there was one physician responsible for seven SCT/year while one nurse was involved for a median of 1.7 SCT/year. Median four rooms/centre (range 1-17) were available for paediatric SCT. The most common isolation facilities were rooms with high efficiency particulate air filtration (HEPA). Eighty-two percent (45/55) of the centres performed allogeneic as well as autologous SCT, while 5% (three centres) offered exclusively allogeneic SCT and 13% (seven centres) used only autologous stem cell rescue. Stem cell source for allogeneic SCT was bone marrow in 87%, peripheral blood (PB) in 10% and umbilical cord blood in 3%. Donors were HLA matched related in 57%, mismatched related in 13%, and matched unrelated in 30% of allogeneic SCT. PB was the most commonly used stem cell source for autologous SCT (48%), followed by BM (41%) and the two together (11%). Data analysis revealed substantial differences in protective care, stem cell processing and transplantation procedures within the centres, irrespective of the country, centre size and transplant type. Keywords: stem cell transplantation; children; isolation rooms; staff; bone marrow harvesting; blood cell support Allogeneic (allo) and autologous (auto) stem cell transplants (SCT) are performed increasingly in children with malignancies, as well as with congenital or acquired haema-

show abstract

Transplantation of bone-marrow cells and fetal thymus in an infant with lymphopenic immunological deficiency

Cited by 12 publications

References 0 publications

Zebrafish kidney stromal cell lines support multilineage hematopoiesis

Zebrafish kidney stromal cell lines support multilineage hematopoiesis

High burden of late effects after haematopoietic stem cell transplantation in childhood: a single-centre study

Transplantation activities and treatment strategies in paediatric stem cell transplantation centres: a report from the EBMT Working Party on Paediatric Diseases

Contact Info

Product

Resources

About