Transplantation of Bone-Marrow Cells and Fetal Thymus in an Infant With Lymphopenic Immunological Deficiency

Primary Immunodeficiencies

“…This child died from intercurrent septicaemia seven weeks after the transplant (Koning et al, 1969;Meuwissen, Terasaki & Good, 1970).…”

“…(5) Implantation of presumed stem-cell fraction from immunologically mature matched donor, with or without thymus graft (Koning et al, 1969).…”

Why Cord Blood?

“…Bach et al [25] for Wiskott-Aldrich syndrome using HLA-identical sibling donors. Another early transplant was reported by the Dutch group in 1969 [26]. Most importantly, the role of HLA as a determinant of the success of transplantation was easily established with sibling-donor transplants, while the antigenic variants of HLA were not sufficiently well defined for effective selection of unrelated donors.…”

Uncomplicated HL-A Matched Sibling Bone Marrow Graft for Combined Immune Deficiency

“…Throughout this period saliva and sera were examined by the method of Ridl (1970) for any emerging monoclonal proteins (as reported by Koning et al, 1969) but none have as yet been detected. A summary of the postgraft immunological status is given in Table II and shown in Fig.…”

“…Elegant techniques for the aseptic delivery of suspected cases (Barnes et al, 1969) and for the fractionation of donor bone marrow grafts (Dicke et al, 1968) have been described and successful grafts have been achieved (Gatti et al, 1968;Koning et al, 1969). These seem beyond the income and facilities of ordinary hospitals, and it has been estimated that some 40 patients a year die untreated in the U.S.A. (F. S. Rosen, personal communication, 1971).…”