Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (The TAM-PAD study)

Abstract

Combined intraarterial and intramuscular transplantation of autologous mononuclear bone marrow stem cells is a clinically feasible and minimally invasive therapeutic option for patients with severe chronic peripheral occlusive arterial disease.

Stem Cell Transplantation for the Treatment of Peripheral Arterial Disease

“…ABI on exercise (from 0.62±0.17 to 0.77±0.15, p=0.018), capillary-venous oxygen saturation (from 50±15 to 62±6%, p=0.027) and venous occlusion plethysmography (from 4.6±1.7 to 6.5±1.7 ml/100 ml tissue/min, p<0.05) exhibited significant improvements as well [61]. Finally, 13 subjects with chronic PAD staged Fontaine IIb received combined intra-arterial and intramuscular BMMNC transplantation [62]. After 2 months, the pain-free walking distance increased significantly by more than 300% (from 147±90 to 500±614 m, p=0.001).…”

“…After 2 months, the pain-free walking distance increased significantly by more than 300% (from 147±90 to 500±614 m, p=0.001). ABI rose, both at rest (from 0.66±0.18 to 0.80±0.15, p=0.003) and on exercise (from 0.64±0.19 to 0.76±0.16, p=0.006) [62]. The authors also found significant improvements in capillary-venous oxygen saturation (from 56±14 to 63±5, p=0.021) and venous occlusion plethysmography (from 2.1±0.7 to 2.5±0.7, p=0.009).…”

“…After 10 weeks, there was a 7-fold improvement of walking distance, a greater than 50% increase of tissue oxygen saturation and a 24% increment of ABI on exercise [58]. Then, 10 patients received intra-arterial (into the common femoral artery) and intramuscular (into the muscles of the thigh and the lower leg) BMMNC transplantation [59]. After 2 months, pain-free walking distance increased significantly (p<0.05) in all patients.…”

“…After 2 months, pain-free walking distance increased significantly (p<0.05) in all patients. Moreover, significant (p<0.05) improvement of ABI, capillary-venous oxygen saturation and parameters of venous occlusion plethysmography were observed [59]. A 63-year-old type 2 diabetic patient with severe intermittent claudication and a recalcitrant ulcer in the right hallux was treated with intra-arterial and intramuscular BMMNC transplantation [60].…”

“…The authors also found significant improvements in capillary-venous oxygen saturation (from 56±14 to 63±5, p=0.021) and venous occlusion plethysmography (from 2.1±0.7 to 2.5±0.7, p=0.009). Importantly, beneficial effects were sustained at 13 months [62]. A4 mixed series of 35 patients (30 with ischaemic diabetic foot, 2 with PAD and 3 with TAO) received BMMNC transplantation after bone marrow mobilisation with GcSF [63].…”