Transplantation of Autologous Cervical Sympathetic Ganglion into the Brain with Parkinson's Disease: Experimental and Clinical Studies

Itakura, Toru; Nakai, Mitsukazu; Nakao, Naoyuki; Ooiwa, Yoshitsugu; Uematsu, Yoshihiko; Komai, Norihiko

doi:10.1177/096368979400301s16

Cited by 5 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autologous transplantation of the superior cervical ganglion (SCG) into the brain (23) increases homovanillic acid in the cerebrospinal fluid and improves motor activity in MPTP-treated mon keys (20,21). There are a few reports demonstrating that parkinsonian patients showed amelioration of bradykinesia and increased Z-DOPA sensitivity after receiving au tologous grafts of the cervical sympathetic ganglion (15)(16)(17). These data suggest that autologous transplanta tion of peripheral sympathetic ganglion can partially restore DAergic function in parkinsonian patients.…”

Section: Introductionmentioning

confidence: 97%

“…It has been shown that transplantation of peripheral sympathetic ganglia into parkinsonian animals (20)(21)(22) or patients (16,17) partially relieves their behavior defi cits and clinical symptoms. Autologous transplantation of the superior cervical ganglion (SCG) into the brain (23) increases homovanillic acid in the cerebrospinal fluid and improves motor activity in MPTP-treated mon keys (20,21).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Xenografting Human T2 Sympathetic Ganglion from Hyperhidrotic Patients Provides Short-Term Restoration of Catecholaminergic Functions in Hemiparkinsonian Athymic Rats

et al. 1999

View full text Add to dashboard Cite

Previous studies have suggested that allografting peripheral sympathetic ganglia, such as superior cervical ganglia, partially relieves clinical or behavioral deficits in parkinsonian patients and animals. However, removal of these ganglia can cause Homer's syndrome, which limits the utilization of this approach. Hyperhidrosis, a disease of excessive sweating, is commonly seen in young Orientals. Treatment of hyperhidrosis often involves surgical removal of the second thoracic sympathetic ganglia (T2G), which contain catecholaminergic neurons. The purpose of our study was to investigate behavioral responses and tyrosine hydroxylase (TH) immunoreactivity in hemiparkinsonian rats at different time points after transplantation of human T2G from hyperhidrotic patients. Athymic Fisher 344 rats were injected unilaterally with 6-hydroxydopamine into the medial forebrain bundle to destroy the nigrostriatal dopaminergic (DA) pathway. The effectiveness of lesions was tested by measuring methamphetamine (MA)-induced rotations. These unilaterally lesioned rats were later transplanted with T2G or T2 fiber tract (T2F) obtained from adult hyperhidrotic patients. Animals grafted with T2G showed a reduction in MA-induced rotation by 2 weeks; however, rotation returned to the pregrafting levels by 3 months. Animals receiving T2F grafts did not show any reduction of rotation over a 3-month period. Animals were later sacrificed for TH immunostaining at different time points. Tyrosine hydroxylase-positive [TH(+)] cell bodies and fibers were found in the lesioned striatum 2-4 weeks after T2G grafting, suggesting the survival of transplants. Two to 3 months after grafting, TH(+) fibers were still found in almost all the recipients. However, TH(+) cell bodies were found in only three of seven rats studied. Animals receiving T2F grafting did not show any TH immunoreactivity in the lesioned striatum over the 3-month period. These data indicate that T2G transplants from adult hyperhidrotic patients can survive and provide transient normalization of the motor behavior in the hemiparkinsonian athymic rats. Because of the short-term improvement in behavior after grafting, the use of T2G in human trials should be cautious at the present time. Further laboratory research is required.

show abstract

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Xenografting Human T2 Sympathetic Ganglion from Hyperhidrotic Patients Provides Short-Term Restoration of Catecholaminergic Functions in Hemiparkinsonian Athymic Rats

et al. 1999

View full text Add to dashboard Cite

show abstract

“…One hundred and six articles were included in the systematic review [ 4 , 13 – 117 ]. Eighty-nine articles reported tissue transplantation or transplantation of mixed cell populations, including 66 articles using embryonic mesencephalic tissues (Additional file 9 : Table S1) [ 13 – 78 ], 16 articles reporting adrenal medulla tissue transplantation (Additional file 10 : Table S2) [ 79 – 94 ], two articles reporting carotid body tissue transplantation [ 95 , 96 ], four sympathetic ganglion tissue transplantation articles [ 97 – 100 ], and one adipose-derived stromal vascular fraction cell transplantation (Fig. 1 b) [ 101 ].…”

Section: Resultsmentioning

confidence: 99%

“…Autologous adrenal medulla and carotid body tissues, and sympathetic neurons were explored as PD treatments because these can either secret DA or exert neurotrophic effects, but their precise therapeutic mechanism is uncertain [ 95 – 100 ]. Tissue transplantation was less investigated in the recent decade.…”

Section: Discussionmentioning

confidence: 99%

Cell-therapy for Parkinson’s disease: a systematic review and meta-analysis

Wang,

Sun,

Peng

et al. 2023

J Transl Med

View full text Add to dashboard Cite

Background Cell-based strategies focusing on replacement or protection of dopaminergic neurons have been considered as a potential approach to treat Parkinson’s disease (PD) for decades. However, despite promising preclinical results, clinical trials on cell-therapy for PD reported mixed outcomes and a thorough synthesis of these findings is lacking. We performed a systematic review and meta-analysis to evaluate cell-therapy for PD patients. Methods We systematically identified all clinical trials investigating cell- or tissue-based therapies for PD published before July 2023. Out of those, studies reporting transplantation of homogenous cells (containing one cell type) were included in meta-analysis. The mean difference or standardized mean difference in quantitative neurological scale scores before and after cell-therapy was analyzed to evaluate treatment effects. Results The systematic literature search revealed 106 articles. Eleven studies reporting data from 11 independent trials (210 patients) were eligible for meta-analysis. Disease severity and motor function evaluation indicated beneficial effects of homogenous cell-therapy in the ‘off’ state at 3-, 6-, 12-, or 24-month follow-ups, and for motor function even after 36 months. Most of the patients were levodopa responders (61.6–100% in different follow-ups). Cell-therapy was also effective in improving the daily living activities in the ‘off’ state of PD patients. Cells from diverse sources were used and multiple transplantation modes were applied. Autografts did not improve functional outcomes, while allografts exhibited beneficial effects. Encouragingly, both transplantation into basal ganglia and to areas outside the basal ganglia were effective to reduce disease severity. Some trials reported adverse events potentially related to the surgical procedure. One confirmed and four possible cases of graft-induced dyskinesia were reported in two trials included in this meta-analysis. Conclusions This meta-analysis provides preliminary evidence for the beneficial effects of homogenous cell-therapy for PD, potentially to the levodopa responders. Allogeneic cells were superior to autologous cells, and the effective transplantation sites are not limited to the basal ganglia. PROSPERO registration number: CRD42022369760

show abstract

Relationships between event-related potentials (P300) and activities of daily living in Parkinson's disease

et al. 2002

View full text Add to dashboard Cite

The correlation between event-related potentials (P300) and activities of daily living was studied in Parkinson's disease. The P300 of 30 patients with Parkinson's disease and 118 normal subjects were recorded. All patients were evaluated by the Mini-Mental State, Kana-hiroi Test, word fluency, Raven's Coloured Progressive Matrices, Osaka Memory Scale, revised Wechsler Adult Intelligence Scale, self-rating depression scale, state-trait anxiety inventory, and Functional Independence Measure. Eight patients showed prolonged P300 latencies. P300 latency showed relationships to the Mini-Mental State (p < 0.05) and cognitive items of the Functional Independence Measure (p < 0.05). P300 amplitude showed a relationship to performance IQ (p < 0.005), Raven's Coloured Progressive Matrices (p < 0.01) and motor items of the Functional Independence Measure (p < 0.05). It was concluded that P300 should be useful in predicting difficulties with activities of daily living in patients with Parkinson's disease.

show abstract

Transplantation of Autologous Cervical Sympathetic Ganglion into the Brain with Parkinson's Disease: Experimental and Clinical Studies

Cited by 5 publications

References 5 publications

Xenografting Human T2 Sympathetic Ganglion from Hyperhidrotic Patients Provides Short-Term Restoration of Catecholaminergic Functions in Hemiparkinsonian Athymic Rats

Xenografting Human T2 Sympathetic Ganglion from Hyperhidrotic Patients Provides Short-Term Restoration of Catecholaminergic Functions in Hemiparkinsonian Athymic Rats

Cell-therapy for Parkinson’s disease: a systematic review and meta-analysis

Relationships between event-related potentials (P300) and activities of daily living in Parkinson's disease

Contact Info

Product

Resources

About