Transplantation: basic science and immune-tolerance

Sugawara, Mizuho; Ichimura, Shigetoshi; Kokubo, Kenichi; Shimbo, Toshihiro; Hirose, M.; Kobayashi, Hirosuke; Hřibová, Petra; Brabcova, Irena; Honsová, Eva; Viklický, Ondřej; Kute, Vivek; Shah, Pankaj; Vanikar, Aruna V; Gumber, Manoj R.; Patel, Himanshu V.; Modi, Pranjal; Trivedi, Hargovind L; Trivedi, Varsha B; Nusrath, Syed; Minz, Mukut; Minz, Ranjana Walker; Sharma, Ashish; Singh, Sarbpreet; Jha, Vivekandanda; Joshi, Kusum; Richter, Rudolf; Köhler, S.; Qidan, Sara; Scheuermann, Ernst; Kachel, Heinz-Georg; Goßmann, Jan; Gauer, Stefan; Seifried, Erhard; Geiger, H; Seidl, Christian; Hauser, Ingeborg A.; Hanssen, Lydia; Frye, Björn C.; Ostendorf, Tammo; Alidousty, Christina; Djudjaj, Sonja; Boor, Peter; Rauen, Thomas; Floege, Jürgen; Mertens, Peter R.; Raffetseder, Ute; García-Cenador, Begoña; López‐Novoa, José M.; Íñiguez, María; Fernández, Víctor; Obanos, Pilar Perez de; Ruiz, Juan Carlos; Sanz-Gimenez, Juan R.; López-Marcos, Joaquín Francisco; García-Criado, Javier; Craenenbroeck, Amaryllis H. Van; Anguille, Sébastien H.; Jürgens, Angelika; Cools, Nathalie; Camp, Kirsten Van; Stein, Barbara; Nijs, Griet; Berneman, Zwi; Ieven, Margareta; Damme, Pierre Van; Tendeloo, Viggo Van; Verpooten, Gert A.; Gohel, Kalpesh; Hegde, Umapati; Gang, Sishir; Rajapurkar, Mohan; Erdogmus, Siyar; Şengül, Şule; Kocak, Senem; Kurultak, İlhan; Kutlay, Sim; Keven, Kenan; Erbay, Bülent; Ertürk, Şehsuvar; Kimura, Shogo; Imura, Junko; Atsumi, Hirokatsu; Fujimoto, Keiji; Chikazawa, Yoshihiro; Nakagawa, Masaru; Hayama, Tomoyuki; Okuyama, Hiroshi; Yamaya, Hideki; Yokoyama, Hitoshi; Libetta, Carmelo; Canevari, Michele; Sepe, Vincenzo; Margiotta, Elisabetta; Meloni, Federica; Martinelli, Claudia; Borettaz, Ilaria; Esposito, Pasquale; Portalupi, Valentina; Morosini, Monica; Solari, Nadia; Canton, Antonio Dal; Rusai, Krisztina; Schmaderer, Christoph; Hermans, Roel C.J.; Lutz, Jens; Heemann, Uwe; Baumann, Marcus; Cantaluppi, Vincenzo; Tamagnone, Michela; Dellepiane, Sergio; Medica, Davide; Dolla, Caterina; Messina, Maria; Manzione, Ana Maria; Tognarelli, Giuliana; Ranghino, Andrea; Biancone, Luigi; Camussi, Giovanni; Segoloni, Giuseppe; Özkurt, Sultan; Şahin, Garip; Degirmenci, Nevbahar Akcar; Temiz, Gökhan; Musmul, Ahmet; Birdane, Alparslan; Tek, Mujgan; Tekin, Neslihan; Akyüz, Fahrettin; Yalçın, Ahmet; López-Valverde, Antonio

doi:10.1093/ndtplus/4.s2.42

Cited by 2 publications

(1 citation statement)

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“…They observed that a richer ECM protein and growth factor content were present in the Triton-treated scaffold than in the SDS-treated scaffold; additionally, cell viability, adherence, and proliferation were higher with the Triton-treated scaffold than with the SDS-treated scaffold (Choi et al, 2015 ). Furthermore, other researchers have demonstrated that the combination of the two agents produces better results (Sugawara et al, 2011 ). In view of these divergences, there is still a need to identify more suitable decellularizing agents to improve the quality of the obtained scaffolds (Table 1 ) (Ross et al, 2009 , 2012 ; Peloso et al, 2013 ; Song et al, 2013 ).…”

Section: Methods and Processes Applied For Organ Decellularizationmentioning

confidence: 97%

Advances in the Knowledge about Kidney Decellularization and Repopulation

Destefani

Sirtoli

Nogueira

2017

Front. Bioeng. Biotechnol.

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End-stage renal disease (ESRD) is characterized by the progressive deterioration of renal function that may compromise different tissues and organs. The major treatment indicated for patients with ESRD is kidney transplantation. However, the shortage of available organs, as well as the high rate of organ rejection, supports the need for new therapies. Thus, the implementation of tissue bioengineering to organ regeneration has emerged as an alternative to traditional organ transplantation. Decellularization of organs with chemical, physical, and/or biological agents generates natural scaffolds, which can serve as basis for tissue reconstruction. The recellularization of these scaffolds with different cell sources, such as stem cells or adult differentiated cells, can provide an organ with functionality and no immune response after in vivo transplantation on the host. Several studies have focused on improving these techniques, but until now, there is no optimal decellularization method for the kidney available yet. Herein, an overview of the current literature for kidney decellularization and whole-organ recellularization is presented, addressing the pros and cons of the actual techniques already developed, the methods adopted to evaluate the efficacy of the procedures, and the challenges to be overcome in order to achieve an optimal protocol.

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