Transplant oncology – Current indications and strategies to advance the field

Krendl, Felix J.; Bellotti, Ruben; Sapisochin, Gonzalo; Schaefer, Benedikt; Tilg, Herbert; Scheidl, Stefan; Margreiter, Christian; Schneeberger, Stefan; Oberhuber, Rupert; Maglione, Manuel

doi:10.1016/j.jhepr.2023.100965

JHEP Reports

2024

DOI: 10.1016/j.jhepr.2023.100965

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Transplant oncology – Current indications and strategies to advance the field

Felix J. Krendl,

Ruben Bellotti,

Gonzalo Sapisochin

et al.

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2024

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Cited by 2 publications

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Expanding MELD exceptions for colorectal liver metastasis: data and policy

Whitrock,

Pratt,

Shah

2024

Current Opinion in Organ Transplantation

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Purpose of review While liver transplant for unresectable colorectal cancer liver metastases (CRLM) has been demonstrated to be a promising treatment in selected patients, the typically low MELD score of these patients and lack of exception points may lead to challenges in receiving a deceased donor liver for transplant. Recent findings Several studies have shown improved outcomes in select patients with CRLM who undergo liver transplant, and several trials are ongoing and will conclude in the next several years. MELD exception points have recently been proposed in qualifying patients with CRLM to help this group obtain more timely quality allografts. Under the current proposal, patients with CRLM would receive a score of the median MELD at transplant (MMaT) for their center minus 20 with a minimum score of 15 in cases where MMaT minus 20 would be less than 15. This would allow them to receive transplants faster without competing unnecessarily with those with greater medical need. Summary Giving MELD exception points to patients with colorectal cancer liver metastases in need of transplant may decrease time on the waitlist and improve outcomes for these patients.

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Expanding MELD exceptions for colorectal liver metastasis: data and policy

Whitrock,

Pratt,

Shah

2024

Current Opinion in Organ Transplantation

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ASO Author Reflections: Ante Situm Hepatectomy—When Transplant and Resection Techniques Are Combined for Extreme Liver Surgery

Addeo,

de Mathelin,

Paul

et al. 2024

Ann Surg Oncol

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Transplant oncology – Current indications and strategies to advance the field

Cited by 2 publications

References 230 publications

Expanding MELD exceptions for colorectal liver metastasis: data and policy

Expanding MELD exceptions for colorectal liver metastasis: data and policy

ASO Author Reflections: Ante Situm Hepatectomy—When Transplant and Resection Techniques Are Combined for Extreme Liver Surgery

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