Transplant‐acquired food allergy (<scp>TAFA</scp>) following cord blood stem cell transplantation in two adult patients with haematological malignancies

Feliu, Jesús; Clay, Jennifer; Raj, Kavita; Barber, Linda D.; Devlia, Vikesh; Shaw, Bronwen E.; Pagliuca, Antonio; Mufti, Ghulam J.

doi:10.1111/bjh.12992

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…Among liver transplant recipients, the liver allograft plays a role in presentation of gut-derived antigens to naïve T cells by liver antigen presenting cells. Among patients with GVHD, the gut derived antigens may increase and lead to Th2 food allergic responses rather than tolerance 7. Food allergy and EGID has been shown to occur among liver transplantation recipients.…”

Section: Discussionmentioning

confidence: 99%

<p>Blood eosinophils and IgE levels among umbilical cord transplantation recipients with food allergies</p>

Dosanjh¹,

Lew²

2019

JAA

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The use of immunosuppressive treatments and their related gastrointestinal adverse effects have been implicated in the development of food allergic responses following transplantation. There is limited information on the pathogenesis of the food allergic immune response among umbilical cord transplantation recipients. This study was conducted to identify a cohort of food allergic umbilical cord recipients in the literature. The literature was searched to systematically identify this cohort. Criteria for inclusion included umbilical cord transplantation, food allergic response, and reported laboratory data. Analysis of the laboratory data using the Pearson method revealed that there was a moderate negative correlation with a coefficient of r =−0.7016 and r 2 =−0.49 between peripheral eosinophilia and serum immunoglobulin E (IgE) levels. Future studies on a larger population are needed, but this study may help to elucidate possible cellular mechanisms involved in this response.

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Section: Discussionmentioning

confidence: 99%

<p>Blood eosinophils and IgE levels among umbilical cord transplantation recipients with food allergies</p>

Dosanjh¹,

Lew²

2019

JAA

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“…The authors connected this with the disruption of tolerance and priming towards Th2 and allergy by demonstrating that these cytokines modulated IL-2 production, suppressing Treg induction and instead promoting an IL-4 expressing T cell that bore similarities to Th2 cells. This potential for extremely early life events to influence food allergy has also been supported by circumstantial clinical evidence in adult patients who underwent cord blood transplantation for hematological disorders and developed new-onset food allergy within a year of transplant, a condition referred to as “Transplant-acquired food allergy” [5, 6]. One caveat to these conclusions is that differences in Tregs from cord blood have already been demonstrated between atopic (individuals with evidence for existing IgE responses) and non-atopic mothers and associate with atopic dermatitis [7, 8].…”

Section: Neonatal and Early-life Influences On Food Allergy Developmentmentioning

confidence: 97%

Balancing Tolerance or Allergy to Food Proteins

Bryce

2016

Trends in Immunology

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Dietary proteins usually induce immune tolerance, and yet may trigger life-threatening immune responses in the case of food allergy. The associated type 2 immunity, linked with specific IgE production and activation of mast cells and basophils, is well understood, but the mechanisms related to preventing food allergy are still being deciphered. Recent insights into the mechanisms that regulate oral tolerance and dietary antigen sampling has revealed unique regulatory events that occur during early life and into adulthood. Drawing from both recent clinical and experimental discoveries, this article focuses on the current evidence for how several key stages of life present mechanistic points that might participate in tipping the balance between food protein tolerance or allergy.

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“…Nutrition education should include topics such as food safety, food hygiene, and food allergies. It is particularly crucial to educate recipients of cord blood transplants, as transplantacquired food allergy could be a serious complication, and guidance regarding this issue is critical to mitigating the risk of such complications 60,61 .…”

Section: Long-term Follow-up Post-allo-hsctmentioning

confidence: 99%

Nutritional support in allogeneic hematopoietic stem cell transplantation Asian perspective

Fuji

Cheng

Yakushijin

et al. 2022

BCT

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an integral part of the treatment strategy for patients with malignant or non-malignant hematological diseases. Clinical outcomes of patients undergoing allo-HSCT have significantly improved in recent decades. However, transplant-related morbidity and mortality remain major issues for allo-HSCT recipients.With regard to nutrition, patients undergoing allo-HSCT are at high risk for malnutrition. It is expected that clinical practice concerning nutritional support in allo-HSCT has been improving in recent decades; however, no data directly support this expectation. One major issue in managing nutritional support during allo-HSCT is the lack of large-scale randomized prospective studies, which leads to a lack of well-established strategies. Accordingly, we need to gather data from studies in non-HSCT and allo-HSCT settings. In some Asia-Pacific countries, a physician's lack of knowledge of nutritional support may impede the application of nutritional support practices recommended by existing guidelines. Another barrier may be the lack of access to an adequately qualified or trained registered dietitian (RD) at allo-HSCT units. Adequate training in the nutritional management of allo-HSCT patients should be provided to all RDs working with HSCT. Herein, we summarize the information on nutritional support in allo-HSCT, focusing on an Asian perspective.

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Transplant‐acquired food allergy (TAFA) following cord blood stem cell transplantation in two adult patients with haematological malignancies

Cited by 7 publications

References 9 publications

<p>Blood eosinophils and IgE levels among umbilical cord transplantation recipients with food allergies</p>

<p>Blood eosinophils and IgE levels among umbilical cord transplantation recipients with food allergies</p>

Balancing Tolerance or Allergy to Food Proteins

Nutritional support in allogeneic hematopoietic stem cell transplantation Asian perspective

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