Transplacental Vitamin K Prevents Haemorrhagic Disease of Infant of Epileptic Mother

Deblay, M.F.; Vert, P; Andre, Matthew J.; Marchal, Francis

doi:10.1016/s0140-6736(82)92371-6

Cited by 84 publications

(33 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As even a prompt i.m. vitamin K injection immediately after birth may be too late for some infants at risk for early HDN [8] several recommendations for the management of delivery in babies from mothers taking anticonvulsants have been given: 10mg vitamin Ka daily taken orally during the last 2 months of pregnancy, [62], 20 mg vitamin KI taken orally daily during the last 2 weeks of pregnancy [19], early consideration of caesarian section if traumatic delivery is anticipated and i.v. injection of vitamin K to the baby in the delivery room [8].…”

Section: ) Vitamin K Prophylaxis A) Classical Hdn Vitamin K Prophylmentioning

confidence: 99%

Vitamin K in infancy

1988

View full text Add to dashboard Cite

Vitamin K has regained paediatric interest due to a recurrence of bleeding caused by deficiency of the vitamin in newborns and young infants. Increasing awareness of these clinical problems, the development of new methods for the detection of vitamin K deficiency and the direct measurement of vitamin K in tissues have stimulated research. Much new data obtained from these studies has proved helpful to the understanding of vitamin K deficiency in infancy. For example low concentrations of vitamin K have been found in fetal and neonatal livers. The implications of these findings with respect to manifest vitamin K deficiency and to new methods for detection of subclinical vitamin K deficiency are discussed. Breast-feeding is a major risk factor for classical haemorrhagic disease of the newborn and for late onset bleeding due to vitamin K deficiency in young infants. The interdependencies between breast-feeding and vitamin K deficiency are discussed on the basis of new data obtained from direct measurement of vitamin K in maternal milk. The review further focuses on pathophysiological concepts of bleeding due to vitamin K deficiency in infancy and current concepts of vitamin K prophylaxis.

show abstract

Section: ) Vitamin K Prophylaxis A) Classical Hdn Vitamin K Prophylmentioning

confidence: 99%

Vitamin K in infancy

1988

View full text Add to dashboard Cite

show abstract

“…A Caesarean section should always be considered if a traumatic delivery is anticipated [4]. An oral dose of 20 mg vitamin K taken by the mother during the last 1±2 weeks of pregnancy [3] has been proposed and proven eective [5] in the prevention of early VKDB. Immediate parenteral vitamin K administration at birth as well as blood sampling for clotting studies should further be performed.…”

Section: Discussionmentioning

confidence: 99%

Early vitamin K deficiency bleeding after maternal phenobarbital intake: management of massive intracranial haemorrhage by minimal surgical intervention

Renzulli

Tuchschmid

Eich

et al. 1998

European Journal of Pediatrics

View full text Add to dashboard Cite

show abstract

“…Although these drugs often control or reduce the frequency of convulsions in majority, some patients show little or no improvement. Synthetic anticonvulsants are associated with hepatotoxicity, aplastic anemia, and deleterious effects on some essential biochemicals such as vitamin D, [4] carnitine, [5] vitamin K, [6] and folic acid [7] on prolonged use. Some neurologists prescribe a ketogenic and Atkins diet as adjuvant along with synthetic anticonvulsants.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Kaushik

2017

IJGP

View full text Add to dashboard Cite

Epilepsy or Apasmara is a common chronic neurological disorder affecting millions worldwide. Abnormal neuronal discharge occurs during seizures. A person with epilepsy is loaded with a variety of synthetic anticonvulsants, which has associated toxicities and degenerative effects on some essential biochemicals and brain antioxidant enzymes on prolonged use. Ketogenic and Atkins diet are sometimes prescribed by neurologists as adjuvant with modern antiepileptics, but their limited use and associated side effects have led to focus on some alternatives. Nidanparivarjan, Shodhan chikitsa, Bahiparimarjan, Rasayana chikitsa, Sattvavajaya and Avasthika chikitsa are basic approaches for treatment of disorders or ailments in Ayurveda. Rasayana chikitsa is preferred for the long-term management of epilepsy, which involves the use of Medhya Rasayana which is a collection of herbs in minute quantities such as Mandukaparni, Yashtimadhu, Guduchi, Tinospora, Ashwagandha, Shankhpushpi, Vacha, and Brahmi. Sarasvata churna is an ayurvedic formulation and as mentioned by Bhavaprakasha and Ayurvedic Formulary of India and is a compound ayurvedic formulation containing Saussurea lappa, Withania somnifera, Rock salt, Carum roxburghianum, Cuminum cyminum, Carum carvi, Piper longum, Piper nigrum, Zingiber officinale, Cissampelos pareira, Convolvulus pluricaulis, Acorus calamus, and Bacopa monnieri. Besides possessing tremendous curing potential, Sarasvata churna is not being prescribed by neurologists for the treatment of epilepsy due to lack of animal and clinical safety data. In this study, the individual component drugs of Sarasvata churna are intensively investigated on pharmacological basis for their respective role in overcoming epilepsy so as to understand the actual mechanisms behind the potential of this thousand years old remedy for epilepsy.

show abstract

Transplacental Vitamin K Prevents Haemorrhagic Disease of Infant of Epileptic Mother

Cited by 84 publications

References 5 publications

Vitamin K in infancy

Vitamin K in infancy

Early vitamin K deficiency bleeding after maternal phenobarbital intake: management of massive intracranial haemorrhage by minimal surgical intervention

Untitled

Contact Info

Product

Resources

About