Transplacental Transmission of Endogenous Interferon in Pregnant Mice inoculated with Influenza or Newcastle Disease Viruses

Korsantiya, B. M.; Smorodintsev, A. A.

doi:10.1038/232560b0

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…It is possible that the presence of interferon in fetuses prior to 14 days after infection of the dams may represent passively transferred maternal interferon. Transplacental transfer of interferon has been observed during the course of nonpathogenic viral infections in rodents (20,26,31). In contrast, data from this laboratory (33) have shown that interferon induced by a nonreplicating togavirus in pregnant sheep or in fetal lambs fails to pass transplacentally in either direction.…”

Section: Cnsmentioning

confidence: 99%

Fetal and adult bovine interferon production during bovine viral diarrhea virus infection

Rinaldo¹,

Isackson²,

Overall³

et al. 1976

Infect Immun

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Levels of interferon in adult bovine serum and in fetal bovine serum and tissues were examined during the course of transplacental bovine viral diarrhea virus infection. The cows produced circulating interferon between 2 and 9 days after viral inoculation, with mean peak levels in the serum on day 4. Interferon could be routinely detected in fetal tissues (e.g., thymus, spleen, and kidney) between days 4 and 21 after viral inoculation of the cows at 149 to 150 days of gestation (mid-second trimester) and in fetal serum from day 13 through day 21. Interferon was also detectable in the serum and tissues of fetuses from dams infected at day 95 of gestation (the beginning of the second trimester). In general, no differences were found between the ability of the adult and fetus to produce interferon. Fetal lamb kidney cells were more sensitive to the antiviral effects of bovine interferon than were fetal bovine kidney cells. The antiviral substance from the fetal and adult animals was characterized as interferon by standard criteria.

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Section: Cnsmentioning

confidence: 99%

Fetal and adult bovine interferon production during bovine viral diarrhea virus infection

Rinaldo¹,

Isackson²,

Overall³

et al. 1976

Infect Immun

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show abstract

“…A few studies have pointed to other compartment barriers restricting general distribution of interferon within the body. The placenta proved to be an effective barrier for interferon, even when inducers were inoculated into the uterus Overall and Glasgow, 1970;Korsantiya and Smorodintsev, 1971;Schafer et al, 1972). In view of the cell-multiplication-inhibitory effect of interferon, the placental barrier for interferon should be extremely important for the welfare of the rapidly developing fetus.…”

Section: Placental and Other Barriersmentioning

confidence: 99%