Transplacental Transfer of Asbestos in Pregnant Mice

Haque, Abida K.; Vrazel, Danet M.

doi:10.1007/s001289900671

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…Small, thin, uncoated asbestos fibers were found in 15 of the 40 stillborn infants, while no fibers were found in the placental tissue of any live-born controls (Haque et al, 1996). Interestingly, in a larger third study by Haque et al (1998) using the same methods, low numbers of asbestos fibers were also found in 15% of the live-born placental controls. This suggests that there is a threshold for prenatal exposure that is lethal to the fetus, but again raises the possibility that the surviving infants have a higher risk for developing childhood mesothelioma.…”

Section: Reproductive and Developemental Effects Of Asbestosmentioning

confidence: 86%

“…It was also demonstrated through the use of EDXA-EM analysis that asbestos is transferred to the fetus through the placenta in pregnant mice given an iv dose of asbestos (Haque & Vrazel, 1998), and transplacental transfer of chrysotile asbestos was also found in rats (Vanchugova et al, 2008). In addition, oral administration of chrysotile asbestos to pregnant mice resulted in fibers detected in the lung and liver of pups by EDXA-EM (Haque et al, 2001).…”

Section: Reproductive and Developemental Effects Of Asbestosmentioning

confidence: 99%

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Nonpulmonary Outcomes of Asbestos Exposure

Bunderson-Schelvan

Pfau

Crouch

et al. 2011

Journal of Toxicology and Environmental Health, Part B

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The adverse pulmonary effects of asbestos are well accepted in scientific circles. However, the extrapulmonary consequences of asbestos exposure are not as clearly defined. In this review the potential for asbestos to produce diseases of the peritoneum, immune, gastrointestinal (GIT), and reproductive systems are explored as evidenced in published, peer-reviewed literature. Several hundred epidemiological, in vivo, and in vitro publications analyzing the extrapulmonary effects of asbestos were used as sources to arrive at the conclusions and to establish areas needing further study. In order to be considered, each study had to monitor extrapulmonary outcomes following exposure to asbestos. The literature supports a strong association between asbestos exposure and peritoneal neoplasms. Correlations between asbestos exposure and immune-related disease are less conclusive; nevertheless, it was concluded from the combined autoimmune studies that there is a possibility for a higher-than-expected risk of systemic autoimmune disease among asbestos-exposed populations. In general, the GIT effects of asbestos exposure appear to be minimal, with the most likely outcome being development of stomach cancer. However, IARC recently concluded the evidence to support asbestos-induced stomach cancer to be “limited.” The strongest evidence for reproductive disease due to asbestos is in regard to ovarian cancer. Unfortunately, effects on fertility and the developing fetus are under-studied. The possibility of other asbestos-induced health effects does exist. These include brain-related tumors, blood disorders due to the mutagenic and hemolytic properties of asbestos, and peritoneal fibrosis. It is clear from the literature that the adverse properties of asbestos are not confined to the pulmonary system.

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Section: Reproductive and Developemental Effects Of Asbestosmentioning

confidence: 86%

Section: Reproductive and Developemental Effects Of Asbestosmentioning

confidence: 99%

Nonpulmonary Outcomes of Asbestos Exposure

Bunderson-Schelvan

Pfau

Crouch

et al. 2011

Journal of Toxicology and Environmental Health, Part B

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“…It had be shown that intraperitoneally administered asbestos fibers were engulfed in phagocytes Winkler and Rüttner, 1982 and we observed the grayish-colored and swollen lymph nodes beside the thymus in the thoracic cavity of dams given MWCNTs or asbestos, in the previous studies [12] , [13] and the present study (data not shown), indicating that those fibrous materials might be carried by lymphatic or blood flow from peritoneal cavity. As the asbestos fibers had been provided on the transplacental distribution form dam to fetus in human and experimental animals (Haque et al, 2001) [3] , [7] , [8] , [9] , the same route to fetus might be speculated in the MWCNTs. However, the existence of MWCNTs in fetus has yet not proved at present.…”

Section: Discussionmentioning

confidence: 98%

Comparison of fetal toxicity of various multi-wall carbon nanotubes in mice

et al. 2015

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The fetal toxicities of multi-wall carbon nanotubes (MWCNTs) with various sizes were compared in CD1(ICR) mice. MWCNTs were suspended in 2% sodium carboxymethyl cellulose solution in phosphate-buffered saline. On day 9 of gestation, dams were administered a single intraperitoneal dose of MWCNTs (4 mg/kg body weight), while dams in the control group were administered vehicle (10 mL/kg body weight). The rectal temperatures of the dams were monitored 2 h after administaration to asses statuses of the dams. The dams and fetuses were examined on day 18 of gestation. The number of live fetus per dam decreased in some MWCNTs-administered groups. The mean percentages of live fetuses in total implantations in the MWCNTs-administered groups markedly varied from 0% to 95%, and the highest mean percentage of live fetuses in the MWCNTs-administered group was equivalent to that of the control group. The decrease in live fetuses depended on an increased number of early dead fetuses. In the groups with markedly lowered rectal temperature after administration, the fetal loss were evident. The blood levels of interleukin-6 and/or monocyte chemoattractant protein-1 in dam 2 h after administration of MWCNTs markedlyr increased, especially in the goups with significant decrease in live fetuses. These results indicated a relationship between inflammation in the dam, which probabely depended on the particular length of the MWCNTs, and the fetal toxicioty of MWCNTs in mice.

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“…This suggests that transplacental transfer of fibers occurs via the maternal circulation (15). In support of this theory, chrysotile (white asbestos) fibers have been observed in newborn mice following gavage feeding of their pregnant mothers, suggesting that the fibers can pass across the placental barrier (17,18). The placental fiber burden may be greater among women with known, heavy asbestos exposure, such as occurred among the women at Wittenoom (7).…”

Section: Discussionmentioning

confidence: 98%

Asbestos Exposure and Gestational Trophoblastic Disease: A Hypothesis

Reid

Heyworth

Klerk

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Among 2,968 women and girls exposed to crocidolite (blue asbestos) at Wittenoom, three cases of choriocarcinoma and three cases of hydatidiform mole have been identified (crude incidence rate of 9.9 per 1000 women and 1.7 per 1000 deliveries for choriocarcinoma and hydatidiform mole, respectively). The women with choriocarcinoma were resident at Wittenoom at the time of disease development, whereas hydatidiform mole occurred much later in women who had first been exposed to asbestos as young girls. Four of the six cases were known to have lived with asbestos company workers who brought their dusty work-clothes home for washing. Asbestos fibers have been reported in the lung, the pleural and peritoneal mesothelium, and the human ovary. They have also been detected in placental digests of live and stillborn infants. This cluster of gestational trophoblastic diseases has some biological plausibility for asbestos causation. Taking an occupational and residential history and examining pathologic specimens for asbestos fibers or bodies may prove useful in patients with gestational trophoblastic disease.

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Transplacental Transfer of Asbestos in Pregnant Mice

Cited by 6 publications

References 18 publications

Nonpulmonary Outcomes of Asbestos Exposure

Nonpulmonary Outcomes of Asbestos Exposure

Comparison of fetal toxicity of various multi-wall carbon nanotubes in mice

Asbestos Exposure and Gestational Trophoblastic Disease: A Hypothesis

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