Transplacental transfer of amitriptyline and nortriptyline in isolated perfused human placenta

Abstract

Both AMI and NOR cross the human placenta. However, the fetal exposure with NOR may be somewhat smaller compared with AMI, probably due to the higher lipophilicity of AMI.

Release of non-neuronal acetylcholine from the isolated human placenta is affected by antidepressants

“…Amitriptyline and doxepin are frequently used. Both of them cross the placenta and are thus present in the maternal and fetal circulation (Heikkinen et al, 2001). The present results clearly demonstrate a suppression of the spontaneous release of non-neuronal ACh from the human placenta in response to amitriptyline or doxepin.…”

Antidepressant Use During Pregnancy and Asthma in the Offspring

“…SSRIs and TCAs are believed to cross the placenta and enter the fetal circulation, 5,23 and many antidepressants influence the serotonin homeostasis. Because serotonin modulates the activity of the respiratory rhythm generator and regulates cell proliferation and maturation of the lung, 6,24 antidepressants may, thereby, influence the development of the lung.…”

Prenatal Antidepressant Exposure: Clinical and Preclinical Findings

“…Steady-state placental perfusion studies of amitriptyline, citalopram, or fluoxetine and their metabolites can reach up to 10% (Heikkinen et al, 2001(Heikkinen et al, , 2002b. In contrast, in vivo studies of umbilical cord medication distribution show much higher transfer of antidepressants as predicted for lipophilic substances.…”