Transplacental passage of fluorides

Gupta, Sunil Kumar; Seth, A. K.; Gupta, Alka; Gavane, A. G.

doi:10.1016/s0022-3476(05)81558-6

Cited by 34 publications

(21 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results observed were in agreement with the previous findings 11,44 . The elevated lipid peroxidation in fluorosis may result from the decreased activities of antioxidant enzymes 45 .…”

Section: Discussionsupporting

confidence: 94%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

This study reports protective effect of Abelmoschus moschatus seed extract against sodium fluoride (NaF) induced alterations in behavior correlated with neurochemical changes in developing brain of rats. Excessive intake of fluoride during pregnancy cross the blood brain barrier (BBB) and cause adverse effects on neonatal development. As the BBB in fetuses, neonates and infants is immature, it cannot provide protection against the entries. The pregnant wistar rats were randomly categorized into six groups of five animals each. Group I is of control rats received normal tap water. Group II is NaF exposed group with 20 ppm (or 20 mgkg -1 body wt.) in their drinking water. Group III rats were treated with A. moschatus aqueous extract (AMAE) (300 mgkg -1 body wt./day/rat) along with NaF water (20 ppm). Group IV rats were treated with A. moschatus ethanolic extract (AMEE) (300 mgkg -1 body wt./day/rat) along with NaF water (20 ppm).Group V and VI rats were treated with AMAE (300 mgkg -1 body wt./day/rat), and AMEE (300 mgkg -1 body wt./day/rat) respectively. On 1 st , 7 th , 14 th , 21 st and 30 th day (postpartum days), the pups were sacrificed to assess oxidative stress markers (LPO, CAT), and measured body weight, brain weight, BSI, and estimated protein content of brain tissue of all experimental groups. On post-natal day 21 and day 30 pups behavioral activity (rota rod, hot plate test) was measured. Fluoride exposure significantly increased lipid peroxidation and decreased the activity of catalase, and decreased body and brain weight, BSI and also protein content of the brain of pups indicating oxidative stress and inhibited antioxidant system and protein synthesis which were reverted on administration of AMAE and AMEE against NaF intoxication. The altered behavioral responses on NaF exposure were also reversed to that of control. Hence, this study proves the vulnerability of developing brain to fluoride toxicity during development and growth and protection offered by AMAE and AMEE towards neurotoxicity of NaF.

show abstract

“…The results observed were in agreement with the previous findings 11,44 . The elevated lipid peroxidation in fluorosis may result from the decreased activities of antioxidant enzymes 45 .…”

Section: Discussionsupporting

confidence: 94%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

show abstract

“…The birth defects occurs by passive diffusion at low maternal plasma concentrations, but the human placenta serves as a partial barrier to registry of the metropolitan Atlanta, Georgia area has been evaluated for evidence of a possible adverse effect of fluori-embryo/fetal exposure when maternal plasma concentrations exceed 0.4 ppm (Armstrong et al, 1970;Shen et al, 1974;dation. Erickson and co-workers (1976) studied data from hospital records of 120,000 live births (1967 to 1973) in the Louw and Van Wyk, 1984;Ron et al, 1986;Gupta et al, 1993). Dynamic interactions among the maternal, fetal, pla-five counties of the metropolitan Atlanta area, and birthcertificate diagnoses for more than 1.25 million live births cental, and amniotic compartments may contribute to interindividual variability in maternal/fetal ratios for circulating in the 29 states and 2 cities covered by the National Cleft Lip and Palate Intelligence Service.…”

Section: Discussionmentioning

confidence: 99%

Developmental Toxicity Evaluation of Sodium Fluoride Administered to Rats and Rabbits in Drinking Water

Heindel

1996

Fundamental and Applied Toxicology

View full text Add to dashboard Cite

“…Several researchers have found a positive correlation between the fluoride concentrations measured in maternal and umbilical cord blood plasma, which suggests that the placenta allows passive diffusion of fluoride from mother to fetus (Gupta et al 1993;Malhotra et al 1993). Studies conducted with laboratory animals indicate that adverse developmental outcomes are possible at very high ingestion rates; but evaluations of developmental defects in human populations have been inconclusive, mostly because the quality of research has been low (Doull et al 2006).…”

Section: Developmental Effectsmentioning

confidence: 99%

Fluoride and environmental health: a review

Ozsvath

2008

Rev Environ Sci Biotechnol

511

238

View full text Add to dashboard Cite

The relationship between environmental fluoride and human health has been studied for over 100 years by researchers from a wide variety of disciplines. Most scientists believe that small amounts of fluoride in the diet can help prevent dental caries and strengthen bones, but there are a number of adverse affects that chronic ingestion at high doses can have on human health, including dental fluorosis, skeletal fluorosis, increased rates of bone fractures, decreased birth rates, increased rates of urolithiasis (kidney stones), impaired thyroid function, and lower intelligence in children. Chronic occupational exposure to fluoride dust and gas is associated with higher rates of bladder cancer and variety of respiratory ailments. Acute fluoride toxicity and even death from the ingestion of sodium fluoride pesticides and dental products have also been reported. The distribution of fluoride in the natural environment is very uneven, largely a result of the geochemical behavior of this element. Fluorine is preferentially enriched in highly evolved magmas and hydrothermal solutions, which explains why high concentrations are often found in syenites, granitoid plutonic rocks, alkaline volcanic, and hydrothermal deposits. Fluoride can also occur in sedimentary formations that contain fluoride-bearing minerals derived from the parent rock, fluoride-rich clays, or fluorapatite. Dissolved fluoride levels are usually controlled by the solubility of fluorite (CaF 2 ); thus, high concentrations are often associated with soft, alkaline, and calcium-deficient waters. Although much is known about the occurrence and health effects of fluoride, problems persist in Third World countries, where populations have little choice in the source of their drinking water and food. However, even in developed nations, fluoride ingestion can exceed the recommended dose when sources other than drinking water are ignored.

show abstract

Transplacental passage of fluorides

Cited by 34 publications

References 7 publications

Untitled

Untitled

Developmental Toxicity Evaluation of Sodium Fluoride Administered to Rats and Rabbits in Drinking Water

Fluoride and environmental health: a review

Contact Info

Product

Resources

About