Transplacental immunization of the human fetus to tetanus by immunization of the mother.

Gill, Thomas J.; Repetti, Charles F.; Metlay, Leon A.; Rabin, Bruce S.; Taylor, Floyd H.; Thompson, Douglass S.; Cortese, Andrea L.

doi:10.1172/jci111071

Cited by 139 publications

(67 citation statements)

References 34 publications

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“…Investigation of transmission of maternal tetanus antibodies (when vaccinated in pregnancy) showed continued highly sensitised responses at 13 months. 65 To investigate if a similar effect is seen with A/H1N1v we have therefore obtained separate funding to follow up the children of the recruited mothers from this study to explore the longer-term protective effect of the passive transfer of immunity. Nevertheless, based on the available data from other studies it seems likely that protection via passively transferred antibodies would persist for at least 6 months, until the child is old enough to receive active vaccination.…”

Section: Figure 2 Results Study Flow Diagram (With Numbers Recruited mentioning

confidence: 99%

“…25, [63][64][65] In the East Midlands, the vaccination programme against A/H1N1v in pregnant women took time to become established. Recruitment of unvaccinated women was easy, but for the first few weeks after the national immunisation programme began there were few women presenting for delivery who had been vaccinated.…”

Section: Figure 2 Results Study Flow Diagram (With Numbers Recruited mentioning

confidence: 99%

See 1 more Smart Citation

Observational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v during pregnancy

Puleston

Bugg²,

Höschler³

et al. 2010

Health Technol Assess

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Section: Figure 2 Results Study Flow Diagram (With Numbers Recruited mentioning

confidence: 99%

Section: Figure 2 Results Study Flow Diagram (With Numbers Recruited mentioning

confidence: 99%

Observational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v during pregnancy

Puleston

Bugg²,

Höschler³

et al. 2010

Health Technol Assess

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“…These children were born with T lymphocyte-mediated antiidiotype reactivity, a priming that might be important if they became infected (15). The fetus can produce specific antibodies against antigens to which the mother has been vaccinated during pregnancy as well (16,17).…”

Section: Discussionmentioning

confidence: 99%

Presence of Non-Maternal Antibodies in Newborns of Mothers with Antibody Deficiencies

et al. 1992

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Samples from four hypogammaglobulinemic moth ers and their newborns as well as two Ig/v-deficient moth ers and their neonates were studi ed. Mother I whose first infant was investigated earlier (1), now had her second baby investigated. From mother II samples from two pregnancies were included. At delivery, we tried to obtain am niotic fluid, cord serum , and mother's serum. Cord blood was taken from the placental side of the umbilical cord. All samples were frozen at -20ce . Du ring the first few days postpartum, mother's and infant's saliva, meconium, and maternal milk (not included in this study) were collected. Samples were frozen immediately at -20°C. The babies had not been given either the mother's or bank milk before the sample was taken. Th e time passed from the last feeding was recorded, as was the mode of feeding. Th e saliva was obtai ned as unstimulated whole saliva with a l-mL syringe or a rounded eye-drop pipette during 15 min and was immediately frozen at -20°C.The hypogamm aglobulinem ic mothers were on proph ylaxis with ' 16.5% Ig intramuscularly (Gammaglobulin; KabiPharmacia, Stockholm, Sweden), a preparation shown to contain idiotypic and antiidiotypic antibod ies to poliovirus type I (HahnZoric M, Carlsson B, Jeansson S, Ekre HP , Osterhaus ADME, Roberton D, Hanson LA., unpubl ished data).Preparation ofmeconium extracts. Previously freeze-dried meconium samples were weighed, and 0.1 g of dry material was dissolved in 3 mL of PBS, pH 7.2, in centrifuge tub es with round bottoms. Glass beads were added to each test tub e and the mixture was shaken on a whirl-mixer six times du ring a 30-min interval with a 5-min pause in between at 4°C. After that, the samples were centrifuged for 20 min at 1500 x g and the clear supernatant was used immediately for analysis. Tween 20 (Merck, Darmstadt, Germany) was added in a concentration of 0.05% to the extracts that were analyzed undiluted. Antibody determ inations. Total maternal serum IgG, IgM, andIgA levels were quantified by radial immunodiffusion (2). 19A 150 ABSTRACT. To explain the mechanism for induction and production of specific antibodies found in the newborn alread y at birth, without previous known exposure to the antigen, we chose a model that presumably excluded the possibility of specific antibodies being transferred from the mother to the fetus. Specific IgG, IgA, and IgM antibodie s against Escherichia coli and poliovirus antigens were determined with ELISA in serum, saliva, and amniotic fluid from hypogammaglobulinemic and IgA-deficient mothers as well as in cord serum, sali va, and meconium from their offspring. All the mothers lacked IgA and some also lacked IgM antibodies , which were found in their healthy newborns. The amniotic fluid from a hypogammaglobulinemic mother lacking IgA contained small amounts of Igaantibodies, which were also found in the neonate, suggesting a fetal origin. There was evidence for the presence of antiidiotypic antibodies to poliovirus in the cord sera. We propose that idiotypic and/or antiidiot ypic IgG ...

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“…In 2 small case series, maternal vaccination against tetanus was associated with the development of antitetanus IgM in the cord blood (21,22). In another case series, influenza-specific IgM was measured in the cord blood of 1 of 8 babies born to vaccinated mothers (23).…”

Section: Introductionmentioning

confidence: 99%

Antigen-specific immune responses to influenza vaccine in utero

Rastogi¹,

Wang²,

Mao³

et al. 2007

J. Clin. Invest.

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Initial immune responses to allergens may occur before birth, thereby modulating the subsequent development of atopy. This paradigm remains controversial, however, due to the inability to identify antigen-specific T cells in cord blood. The advent of MHC tetramers has revolutionized the detection of antigen-specific T cells. Tetramer staining of cord blood after CMV infection has demonstrated that effective CD8 + antigen-specific immune responses can follow intrauterine viral infections. We hypothesized that sensitization to antigens occurs in utero in humans. We studied cord blood B and T cell immune responses following vaccination against influenza during pregnancy. Anti-Fluzone and anti-matrix protein IgM antibodies were detected in 38.5% (27 of 70) and 40.0% (28 of 70), respectively, of cord blood specimens. Using MHC tetramers, HA-specific CD4 + T cells were detected among 25.0% (3 of 12) and 42.9% (6 of 14) of cord blood specimens possessing DRB1*0101 and DRB1*0401 HLA types, respectively, and were detected even when the DRB1 HLA type was inherited from the father.

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Transplacental immunization of the human fetus to tetanus by immunization of the mother.

Cited by 139 publications

References 34 publications

Observational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v during pregnancy

Observational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v during pregnancy

Presence of Non-Maternal Antibodies in Newborns of Mothers with Antibody Deficiencies

Antigen-specific immune responses to influenza vaccine in utero

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