Transplacental Hemorrhage, Cell Transfer, Trauma

Benirschke, Kurt; Kaufmann, Peter

doi:10.1007/978-1-4757-4196-4_17

Cited by 5 publications

(5 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously mentioned, direct injury of the placenta caused a disruption of villous tissue in which fetal–maternal transfusion readily occurred, and induced the elevation cell‐free fetal DNA levels (e.g. from external version or mechanical contusion) 14,15 . As fetal distress was noted at a later period in some cases of traffic accidents (more than 20 h), the measurement of fetal DNA early on might have a clinically useful prognostic value.…”

Section: Discussionmentioning

confidence: 99%

Sex‐determining region Y levels in maternal plasma: Evaluation in abnormal pregnancy

Shimada

Murakami

Shozu

et al. 2004

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Aim: A number of studies for the measurement of cell‐free fetal DNA in maternal blood have been reported; however, their clinical significance has remained unclear. We proposed to clarify the relationship between fetal DNA levels and obstetrical disorders. Methods: One hundred and eighty‐five cases of normal pregnancy, ranging from 8 to 40 weeks’ gestation, and 70 cases of abnormal pregnancy were included. SRY levels in maternal plasma were quantified with a real‐time quantitative polymerase chain reaction. Results: Sex‐determining region Y (SRY) levels and the number of patients with positive levels peaked at 33–36 weeks in normal pregnancy. The SRY levels in threatened abortion (11.6 ± 4.8 copies/mL to 0 ± 0, P < 0.05) and threatened preterm labor (44.6 ± 16.1 copies/mL to 15.9 ± 6.2, P < 0.01) were significantly higher than those of the normal group. In pre‐eclamptic patients, SRY levels were markedly higher than those of the normal group (173.2 ± 94.8 copies/mL to 22.4 ± 8.9, P < 0.05). Patients with premature separation of the placenta (266.8 ± 137.1 copies/mL to 4.9 ± 3.7, P < 0.05) and placenta previa (167.7 ± 32.4 copies/mL to 37.0 ± 17.3, p <0.01) also showed elevated SRY levels. Conclusion: Sex‐determining region Y levels in maternal plasma were elevated in patients with an abnormal pregnancy, particularly those with placental injury of damage. These results suggested that increased SRY levels are consistently caused by the leak of fetal components, and thus the measurement of SRY levels in maternal plasma is useful for the evaluation of placental injuries.

show abstract

Section: Discussionmentioning

confidence: 99%

Sex‐determining region Y levels in maternal plasma: Evaluation in abnormal pregnancy

Shimada

Murakami

Shozu

et al. 2004

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…The pathogenesis of IVT remains unclear; however, numerous investigators suspect that the leakage of fetal components (blood cells or trophoblastic cells) into the maternal circulation is a consequence of IVH. 4 Jauniaux et al 6 also reported a case of large placental IVT associated with elevated maternal serum alphafetoprotein levels.…”

Section: Discussionmentioning

confidence: 97%

“…IVH contains several histological types, such as IVT, maternal lakes, and caverns. 4 IVT is commonly found in the placentas of both normal and abnormal pregnancies. IVT, including small lesions, occurs in 10% to 20% of pregnancies; a higher incidence occurs in patients with Rh isoimmunization.…”

Section: Discussionmentioning

confidence: 99%

“…IVT, including small lesions, occurs in 10% to 20% of pregnancies; a higher incidence occurs in patients with Rh isoimmunization. 4 Although IVT is not commonly associated with significant maternal or fetal morbidity, Soma et al reported secondary compli-cations. 5 They cited a cesarean section rate of 29.8% and found an incidence of abruptio placentae in 5.0% of pregnancies; 2.3% of the fetuses exhibited intrauterine growth restriction.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fetal DNA Levels in Maternal Blood Correlated with Fetal Prognosis in a Case of Intervillous Hematoma

Murakami

Shimada²,

Maeda³

et al. 2003

Am J Perinatol

View full text Add to dashboard Cite

Several methods for detection of fetal components in maternal blood have been reported. However, few have proven clinically useful for determining the treatment in cases of placental injuries. Here, we report a case of extensive intervillous hematoma diagnosed at 25 weeks of gestation with severe intrauterine growth restriction and oligohydramnios. Marked elevation of fetal DNA levels was observed in maternal blood. Fetal DNA levels decreased after 27 weeks of gestation, concurrent with recovery of fetal growth. We conservatively managed this case until 30 weeks of gestation, when a male infant was delivered. He weighed 508 g and displayed Apgar scores of 7 at 1 minute and 9 at 5 minutes. Histological examination of the placenta revealed intervillous thrombosis without infarction or inflammatory changes. In this case, decreasing fetal DNA levels in maternal plasma correlated with recovery of fetal growth and provided useful information for fetal management as well as insight into the pathogenesis of placental injuries.

show abstract

“…On the basis of embryological studies and clinical observations, we can conclude that in the third trimester the placental membrane is very fragile. Histopathological findings provide evidence that the third trimester placenta is more susceptible to transplacental bleeding (13).…”

Section: Discussionmentioning

confidence: 99%

ABO fetomaternal compatibility poses a risk for massive fetomaternal transplacental hemorrhage

Žižka

Fait

Belošovičová

et al. 2008

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

Transplacental Hemorrhage, Cell Transfer, Trauma

Cited by 5 publications

References 127 publications

Sex‐determining region Y levels in maternal plasma: Evaluation in abnormal pregnancy

Sex‐determining region Y levels in maternal plasma: Evaluation in abnormal pregnancy

Fetal DNA Levels in Maternal Blood Correlated with Fetal Prognosis in a Case of Intervillous Hematoma

ABO fetomaternal compatibility poses a risk for massive fetomaternal transplacental hemorrhage

Contact Info

Product

Resources

About