Transplacental effects of diethylstilbestrol on the genital tract of hamster offspring

Rustia, Mario; Shubik, Philippe

doi:10.1016/s0304-3835(75)96099-1

Cited by 44 publications

(14 citation statements)

References 18 publications

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“…In the mouse, perinatal exposure to exogenous estrogen elicits particularly severe disruption of myometrial development, as reported herein and by others (Ostrander et al, 1985;Talamantes and Browning, 1972;Taguchi and Nishizuka, 1985;Gilloteaux et al, 1982;Aihara et al, 1980;Maier et al, 1985;Rustia and Shubik, 1976). While the early changes elicited by DES in the rat and mouse (increased circular orientation of uterine rnesenchyme and increased expression of actin) are similar, in the mouse they progress to severe myometrial disruption, while in the rat the long-term morphological outcome is somewhat less severe.…”

Section: Des Dosage (Pg)supporting

confidence: 83%

“…While the early changes elicited by DES in the rat and mouse (increased circular orientation of uterine rnesenchyme and increased expression of actin) are similar, in the mouse they progress to severe myometrial disruption, while in the rat the long-term morphological outcome is somewhat less severe. In the hamster, DES elicits uterine malformations of equal or even greater severity than those in the mouse because of the extensive proliferation of glands (adenomyosis) throughout the rnyometrium (Rustia and Shubik, 1976;Gilloteaux et al, 1982). Thus, it is evident that while the mechanism of action of DES on uterine mesenchymal differentiation may proceed by certain common pathways, the ultimate outcome clearly demonstrates species differences.…”

Section: Des Dosage (Pg)mentioning

confidence: 99%

“…Immediate effects of estrogens on the developing uterus include qualitative and quantitative changes in protein synthesis (Newbold et al, 1981(Newbold et al, , 1984 and stimulation of epithelial proliferation (Forsberg, 1970;Eide, 1975a,b;Bigsby and Cunha, 1986). In adult mice treated neonatally with estrogen, the uterine epithelium may ex-Q 1989 ALAN R. LISS, INC press cystic hyperplasia (Takasugi et al, 1970;Yasuda et al, 1977;Rustia and Shubik, 1976;McLachlan et al, 1980;McLachlan and Fabro, 1982;Wordinger and Morrill, 1985) and/or squamous metaplasia (Dunn and Green, 1963;Takasugi and Bern, 1964;Rustia and Shubik, 1976;Yasuda et al, 1977;Mori, 1977;Vorherr et al, 1979;Baggs et al, 1980;Ennis and Davies, 1982;Wong et al, 1982;Walker 1980Walker , 1983Ostrander et al 1985). These proliferative lesions may progress to uterine adenocarcinoma (Rustia and Shubik, 1976;Napalkov and Anisimov, 1979;Vorherr et al, 1979;McLachlan et al, 1980;Gilloteaux et al, 1982;Walker, 1983).…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, adenomyosis, the growth of uterine glands and endometrial stroma into the myometrium, has been reported. This condition results in the disruption of the myometrium (Rustia and Shubik, 1976;Guttner, 1980;McLachlan et al, 1980;Huseby and Thurlow, 1982;Walker, 1983;Ostrander et al, 1985). On the other hand, under circumstances in which the integrity of the myometrium is maintained, numerous investigators have reported a thinning of this layer (Talamantes and Browning, 1972;Ostrander et al, 1985;Aihara et al, 1980;Taguchi and Nishizuka, 1985;Maier et al, 1985;Gilloteaux et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

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Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Brody

Cunha

1989

Am. J. Anat.

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The effects of diethylstilbestrol (DES) treatment on myometrial development from the prenatal to adult period were examined in rats and mice by histologic and immunocytochemical methods using anti-actin, -vimentin, and -laminin to assess cytodifferentiation of smooth muscle and fibroblastic cells, and by morphometric procedures to assess quantitatively the effect of DES on the expression of cellular orientation in the emerging inner circular myometrial layer. Neonatal rats and mice were treated with DES from day 0 (day of birth) to day 2 with dosages known to perturb myometrial development. Neonatal treatment with DES increased the degree of circular orientation within the uterine mesenchyme, an effect detectable following as little as 24 hr of DES treatment. This effect on spatial organization of the mesenchyme was followed by an increase in the thickness of the actin-positive middle layer (prospective circular myometrium) of uterine mesenchyme during days 3-15; from day 15 onward, however, the circular myometrial layer began to fragment into irregular bundles of smooth muscle, and the longitudinal myometrial layer became thinner and more irregularly organized than controls. Vimentin localization in rats treated with DES neonatally was more intense than in controls within the circularly orientated uterine mesenchyme at 5 days. By 60 days the circular and longitudinal myometrial layers of DES-treated animals showed strands and bundles of vimentin-positive cells, which were not present in controls. Both rats and mice show comparable effects of DES treatment.

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Section: Des Dosage (Pg)supporting

confidence: 83%

Section: Des Dosage (Pg)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Brody

Cunha

1989

Am. J. Anat.

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“…Studies have been made in the mouse [14][15][16][17][18][19][20][21][22][23][24]. in the rat [25][26][27], and in the hamster [28][29][30]. Highman [31] re ported the effects of DES and estradiol-17(3 in the diet of the mouse.…”

Section: Introductionmentioning

confidence: 99%

Effects of Maternal Administration of Diethylstilbestrol and Estradiol on the Newborn Guinea Pig

Davies¹,

Russell²,

Davenport³

1985

Cells Tissues Organs

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The subcutaneous injection of diethylstilbestrol (2.5 µg/day) into pregnant guinea pigs from the 28th or 40th day to term resulted in an accelerated tempo of differentiation of the genital tract of the female offspring at birth, as well as intense estrogenic stimulation. Estradiol (50 µg per day) injected over the same period caused insignificant estrogenic stimulation in the newborn. The normal embryogenesis of the genital tract is described and a pattern of caudocranial differentiation identified. The normal genital tract is described as a basis for the analysis of results in the newborn. Comparative studies in other animals are discussed.

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A selection of candidate compounds for in vitro teratogenesis test validation

Smith

Kimmel

Kochhar

et al. 1983

Teratog. Carcinog. Mutagen.

110

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The Consensus Workshop on In Vitro Teratogenesis Testing recommended that test validation be facilitated by a listing of agents with defined teratogenicity; subsequently, a panel was convened to review and select such agents. This communication established a list of 47 compounds or conditions which demonstrate a wide range of teratogenicity in vivo. The agents were chosen primarily on the strength of the literature base denoting their in vivo effects. The tables note a number of general biological and toxicological characteristics for each agent, and the details of representative in vivo teratology studies are summarized and referenced. This list is intended to serve as a base for in vitro teratogenesis test validation and should prove useful in developing and identifying those systems which will contribute to a more effective testing program.

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Transplacental effects of diethylstilbestrol on the genital tract of hamster offspring

Cited by 44 publications

References 18 publications

Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Effects of Maternal Administration of Diethylstilbestrol and Estradiol on the Newborn Guinea Pig

A selection of candidate compounds for in vitro teratogenesis test validation

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