Transplacental Distribution of Lidocaine and Its Metabolite in Peridural Anesthesia Administered to Patients With Gestational Diabetes Mellitus

Abstract

Gestational diabetes mellitus did not affect the transplacental transfer of lidocaine but interfered with the transfer of MEGX, acting as a mechanism facilitating the transport of the metabolite.

Effect of type 2 diabetes mellitus on the pharmacokinetics and transplacental transfer of nifedipine in hypertensive pregnant women

“…The ratios of nifedipine concentration in the intervillous space to that in the maternal vein were 0.78 for CG and 0.87 for T2DM subjects, with equilibrium being observed between these collection sites. We have previously detected that concentration ratios for lidocaine in normal pregnant women were 1.01 and for diabetic pregnant women were 0.88 . These findings corroborate that the intervillous space is a continuous region of the maternal vein, which may be considered as a single compartment.…”

Simultaneous determination of five alkaloids from Rauvolfia vomitoria in rat plasma by LC‐MS/MS: Application to a comparative pharmacokinetic study in normal and type 2 diabetic rats

“…During the past several years, intense investigative and clinical efforts have focused on the impact of drug‐altered pharmacokinetics in diabetes [9]. Diabetes mellitus can alter the kinetic disposition and the metabolism of drugs on the investigated drug, and on its metabolic and excretion pathways [10–12]. Recently, some papers reported that the pharmacokinetics of clinical drugs is altered in individuals with diabetes mellitus, including gentamicin [13], metoprolol [14], berberine [15], baicalin [16], catalpol [17], and geniposide [18].…”

Farmacocinética e análise da distribuição placentária da betametasona em gestações gemelares

“…De acordo com os estudos de Filgueira et al (2017) e Moises et al (2015), o espaço interviloso se comporta como uma continuação da veia materna, considerando então esse espaço como um único compartimento. No presente estudo, a concentração de betametasona encontrada no espaço interviloso foi menor ao ser comparado com a concentração encontrada na veia materna, no momento do parto, e maior quando comparada as concentrações da veia umbilical.…”