Transplacental carcinogens and mutagens: Childhood cancer, malformations, and abortions as risk indicators

Hemminki, Kari; Saloniemi, Irma; Luoma, Katariina; Salonen, Tuula; Partanen, Timo; Vainio, Harri; Hemminki, Elina

doi:10.1080/15287398009529932

Cited by 38 publications

(11 citation statements)

References 18 publications

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“…In the first study to relate parental occupation to childhood cancer, children whose fathers were engaged in "hydrocarbon-related'' occupations were found to be at a twofold higher risk of death from cancer than children whose fathers were not so employed [Fabia and Thuy, 19741. Since this report, other investigators have addressed the question of parental occupation and risk of cancer in offspring, with mixed results [Hakulinen et al, 1976;Kantor et al, 1979;Kwa and Fine, 1980;Zack et al, 1980;Hemminki et al, 1980Hemminki et al, , 1981Peters et al, 1981;Sanders et al, 1981;Gold et al, 1982;Wilkins and Koutras, 1983;Wilkins and Sinks, 1984a,b;Peters and Preston-Martin, 1984;Hicks et al, 1984;Shaw et al, 1984;Vianna et al, 1984;Van Steensel-Moll et al, 1985;Spitz and Johnson, 1985;Olshan et al, 1986;Lowengart et al, 1987;Johnson et al, 19871. With one exception [Sanders et al, 19811, all published articles available for review describe the results of a case-control study in which parental employment information was (in most studies) obtained from either personal interviews or occupation/industry statements on birth certificates.…”

Section: Introductionmentioning

confidence: 92%

Paternal occupation and brain cancer in offspring: A mortality‐based case‐control study

Wilkins

Koutras

1988

American J Industrial Med

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A mortality-based case-control study of selected risk factors for childhood brain tumors was undertaken. Ohio-born children who died from brain cancer during the [1959][1960][1961][1962][1963][1964][1965][1966][1967][1968][1969][1970][1971][1972][1973][1974][1975][1976][1977][1978] vicennium were compared to control children (of the same age, race, and sex) by using information obtained from the subjects' birth certificates. Differences between the case and the control children with respect to paternal occupation, the focus of the study, were examined. Controlling for the potentially confounding effects of several nonoccupational factors, case fathers were found more likely than control fathers to have been employed (at the time of birth of their children) in agriculture, in metal-related jobs, in structural work jobs in the construction industry, and in electrical assembling, installing, and repairing occupations in the machinery industry. Although the results must be interpreted with caution, the findings lend support to the hypothesis that parental occupation is a potential risk factor for childhood brain tumors.

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Section: Introductionmentioning

confidence: 92%

Paternal occupation and brain cancer in offspring: A mortality‐based case‐control study

Wilkins

Koutras

1988

American J Industrial Med

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“…Many studies have been published on the effect of occupational exposures on asthma in adults (11,12) and on the possible effects of parental occupations on the health of children and adolescents (13)(14)(15)(16)(17). However, medical research has not established whether parental occupational exposures are associated with the development of asthma in offspring.…”

Section: Introductionmentioning

confidence: 96%

Parental Occupation and Risk of Hospitalization for Asthma in Children and Adolescents

Sundquist

2009

Journal of Asthma

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Our aim was to analyze risk of first hospital diagnosis of asthma in children (< 10 years) and adolescents (10 through 19 years) in Sweden between 1970 and 2004 by parental occupation, controlling for potential confounders. Data from the Multigeneration Register, in which all children born in Sweden from 1932 onward are registered with their parents, were linked to nationwide Hospital Register data. Standardized incidence ratios (SIRs) with 95% confidence intervals were calculated. A total of 47,019 first hospital diagnoses of asthma were recorded in children and 9,032 in adolescents. After accounting for age at diagnosis, sex, socioeconomic status, geographic region, parental history of a first hospital diagnosis of asthma, and period of diagnosis, 17 parental occupational groups were associated with increased risk of first hospital diagnosis of asthma in children and 9 with increased risk in adolescents. Seven parental occupational groups were associated with significantly increased risks in both children and adolescents: "nurses," "assistant nurses," "drivers," "chemical process workers," "cooks and stewards," "home helpers," and "building caretakers and cleaners." Significantly decreased SIRs were observed for those whose parents had higher socioeconomic status. We conclude that parental occupation affects risk of first hospital diagnoses of asthma in children and adolescents.

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“…Long-term monitoring and systematic record keeping of pregnancy anomalies would help identify harmful products. Compounds that are poisonous and teratogenic to the embryo may also prove to be carcinogenic [Hemminki et al, 1980;Sorsa et al, 1985].…”

Section: Health Outcomes Among Researchers Laboratory Workers Chemimentioning

confidence: 99%

Occupational risk in health care and research

Vecchio¹,

Sasco

Cann

2003

American J Industrial Med

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Transplacental carcinogens and mutagens: Childhood cancer, malformations, and abortions as risk indicators

Cited by 38 publications

References 18 publications

Paternal occupation and brain cancer in offspring: A mortality‐based case‐control study

Paternal occupation and brain cancer in offspring: A mortality‐based case‐control study

Parental Occupation and Risk of Hospitalization for Asthma in Children and Adolescents

Occupational risk in health care and research

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