Transplacental Carcinogenic Potential of the Carbamate Fungicide Mancozeb

Shukla, Yogeshwer; Arora, Aanchal

doi:10.1615/jenvironpatholtoxicoloncol.v20.i2.70

Cited by 36 publications

(22 citation statements)

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“…These observations indicate that chronic exposure to mancozeb concentrations significantly lower than those considered toxic may dramatically impact reproductive ovarian functions by interfering with normal cell cycle progression. This hypothesis is supported by the finding that the fungicide is capable of inducing neoplastic transformation in mouse fetal cells appropriately stimulated with tumor promoters [182].…”

Section: B2) Specific Effects Of Mancozeb On the Mammalian Ovarymentioning

confidence: 81%

The Effects of the Endocrine Disruptors Dithiocarbamates on the Mammalian Ovary with Particular Regard to Mancozeb

Cecconi

Paro²,

Rossi³

et al. 2007

CPD

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Many human-made chemicals are called endocrine disruptors (EDs) because they have the potential to disrupt endocrine functions in exposed organisms. Many EDs can disrupt hormonal homeostasis by interfering with hormone receptor recognition, binding and activation, while others act by still unknown mechanisms. Among the EDs specifically affecting the female reproductive system, those with steroidogenic/antisteroidogenic effects have been extensively studied and the mechanisms of toxicity clarified also at molecular level. For many others, information is restricted to few epidemiological data and in vivo/in vitro experiments with animal models. This is the case of the dithiocarbamates, and in particular of the fungicide mancozeb, an ethylenedithiocarbamate widely used to protect fruit and vegetables, ginseng included, because of its low acute toxicity in humans. Although the mechanism(s) by which mancozeb may specifically act on female reproductive organs are largely unknown, data on experimental animals in vivo have demonstrated that the fungicide can induce several disturbances on estrus cycle. When used in vitro at concentrations considered too low to cause human health injuries, the fungicide impairs mouse embryo development and meiotic spindle assembly. The possibility that the female germ cell (the oocyte) could be a specific target of mancozeb suggests a role for this fungicide as probable inductor of infertility also in exposed human populations.

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Section: B2) Specific Effects Of Mancozeb On the Mammalian Ovarymentioning

confidence: 81%

The Effects of the Endocrine Disruptors Dithiocarbamates on the Mammalian Ovary with Particular Regard to Mancozeb

Cecconi

Paro²,

Rossi³

et al. 2007

CPD

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“…While effects of prenatal exposure to MPTP are equivocal, MPTP can have adverse effects after crossing the placenta into the fetus in mice and non-human primates [Weissman et al, 1989;Melamed et al, 1990;Ochi, et al, 1991;Perez-Otano et al, 1992. Likewise, PQ and DTCs are able to cross the placenta [Ingebrigsten et al, 1984;Larsson et al, 1976;Chernoff et al, 1979;Shukla et al, 2001] but effects of these compounds on the nigrostriatal DA system have not been reported.…”

Section: Introductionmentioning

confidence: 99%

A Fetal Risk Factor for Parkinson’s Disease

Barlow¹,

Richfield

Cory‐Slechta

et al. 2004

Dev Neurosci

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A lack of strong evidence for genetic heritability of idiopathic Parkinson’s disease (PD) has focused attention on environmental toxicants in the disease etiology, particularly agrichemicals. PD is associated with advanced age, but it is unclear whether specific neuronal damage could result from insults during development. This study hypothesized that prenatal exposure to pesticides would disrupt the development of the nigrostriatal dopamine (DA) system and enhance its vulnerability to dopaminergic neurotoxicant exposures later in life. Pregnant C57BL/6J mice were treated on gestational days 10–17 with saline or the pesticides maneb (MB, 1 mg/kg) or paraquat (PQ, 0.3 mg/kg). When offspring were evaluated in adulthood, there were no significant effects of prenatal MB or PQ exposure on locomotor activity. Subsequently, offspring were treated for 8 consecutive days with saline, MB (30 mg/kg), or PQ (5 mg/kg). One week after the last exposure, only males exposed to prenatal MB and adulthood PQ showed significant reductions in locomotor activity (95%) and changes in striatal neurochemistry. Stereological assessment of the substantia nigra pars compacta (SNpc) and ventral tegmental area correspondingly confirmed selective dopaminergic-neuron loss in SNpc. The lack of changes in other exposure groups suggests a specificity to the sequence of exposures as well as gender specificity. These results suggest that prenatal exposure to MB produces selective, permanent alterations of the nigrostriatal dopaminergic system and enhances adult susceptibility to PQ exposure. This study implicates a role for developmental neurotoxicant exposure in the induction of neurodegenerative disorders such as PD.

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“…Among the 27 fungicides applied in Russia to prevent the late blight infection during the plant vegetation, 14 contain mancozeb or other dithiocarbamates. When these fungicides get into the soil and come into contact with water and oxygen, their active compounds degrade into ethylene thiourea; this compound has a carcinogenic and mutagenic effect and causes endocrine disorders in laboratory animals (Shykla, Arora, 2001). There are some other active ingredients applied in potato in Russia which are also considered hazardous for human health and environment (Twining et al, 2009).…”

Section: Efficiency Of a Computerised Decision Support System As A Tomentioning

confidence: 99%

Efficiency of a computerised decision support system as a tool to reduce fungicide input for the control of potato late blight

Filippov

Rogozhin

Кузнецова

et al. 2015

Zemdirbyste-Agriculture

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The VNIIFBlight decision support system is intended to identify weather conditions favourable or unfavourable for the late blight outbreaks on potato. To provide an improved choice of fungicide treatment dates, we investigated the use of a standard five-day weather forecast based disease management decision support system VNIIFBlight as well as the use of information about the late blight resistance level of the cultivars used. The efficiency of this decision support system was compared with a seven-day routine program of fungicide treatments in the course of four-year field trials in Moscow region and six-year "virtual" trials in four regions of Russia, three regions of Lithuania, and single regions of Canada, Ukraine, Poland, and the Netherlands. According to the results of field experiments, in the case of a high infection pressure (2004 and 2008), yield losses caused by late blight in the untreated control made up 62% and 39%, respectively, whereas the losses for both compared schemes of protection did not exceed 8.2% for both years. In the case of weak disease development (2005 and 2007), for all studied treatments, including the untreated control, yield losses did not exceed 3%. In all years, the use of the VNIIFBlight decision support system significantly reduced the number of fungicidal treatments as compared to the routine scheme of protection; this reduction in 2004, 2005, 2007 and 2008 made up 62, 50, 50 and 17 %, respectively. According to the results of "virtual" trials, the use of the VNIIFBlight decision support system reduced the number of fungicide treatments of susceptible and resistant potato cultivars by 50% and 60% on average, respectively, as compared with the routine program.

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Transplacental Carcinogenic Potential of the Carbamate Fungicide Mancozeb

Cited by 36 publications

References 0 publications

The Effects of the Endocrine Disruptors Dithiocarbamates on the Mammalian Ovary with Particular Regard to Mancozeb

The Effects of the Endocrine Disruptors Dithiocarbamates on the Mammalian Ovary with Particular Regard to Mancozeb

A Fetal Risk Factor for Parkinson’s Disease

Efficiency of a computerised decision support system as a tool to reduce fungicide input for the control of potato late blight

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