Transparent equine collagen biomatrix as dural repair. A prospective clinical study

Gazzeri, Roberto; Neroni, Massimiliano; Alfieri, Alex; Galarza, Marcelo; Faiola, Andrea; Esposito, Stefano; Giordano, Marco

doi:10.1007/s00701-009-0290-9

Cited by 37 publications

(33 citation statements)

References 19 publications

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“…After 24 weeks, there was a further regression of inflammatory infiltrates and continuity between the highly collagenous endogenous dura and the newly formed collagen fibers of neodura. In another case report, histological examination of a tissue sample taken 40 days after implantation of a collagen matrix revealed that the graft had been replaced by significant ingrowth of the native dura (Gazzeri et al, 2009). Similarly, in our two patients with recurrent meningiomas who required re-operation, long-term follow-up using histopathological and ultra structural techniques demonstrated re-absorption of the TissuDura and regeneration of dura mater.…”

Section: Non-watertight Dural Reconstruction With Collagen Matrixsupporting

confidence: 69%

Dural Reconstruction in Meningioma Surgery

Parlato¹,

Granata²,

Moraci³

et al. 2012

Meningiomas - Management and Surgery

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Section: Non-watertight Dural Reconstruction With Collagen Matrixsupporting

confidence: 69%

Dural Reconstruction in Meningioma Surgery

Parlato¹,

Granata²,

Moraci³

et al. 2012

Meningiomas - Management and Surgery

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“…This membrane can be damaged by trauma to the brain or spinal cord 3,4 . Many synthetic and natural materials are employed in neurosurgery to repair dural defects 2,[5][6][7][8][9][10][11][12][13][14][15][16] . However, autografts require an accessible site and an additional operation for obtaining a healthy region of the dura.…”

Section: Introductionmentioning

confidence: 99%

Development of a glial cell-derived neurotrophic factor-releasing artificial dura for neural tissue engineering applications

Mohtaram

Agbay

et al. 2015

J. Mater. Chem. B

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Encapsulated electrospun nanofibers can serve as an artificial dura mater, the membrane that surrounds the brain and spinal cord, due to their desirable drug delivery properties. Such nanofiber scaffolds can be used to deliver drugs such as glial cell-derived neurotrophic factor (GDNF). GDNF promotes the survival of both dopaminergic and motor neurons, making it an important target for treatment of central nervous system injuries and disorders. This work focuses on designing a novel class of encapsulated poly(ε-caprolactone) (PCL) nanofiber scaffolds with different topographies (random and aligned) that generate controlled release of GDNF to potentially serve as a suitable substitute for the dura mater during neurosurgical procedures. Random and aligned scaffolds fabricated using solutiom electrospinning were characterized for their physical properties and their ability to release GDNF over one month. GDNF bioactivity was confirmed using a PC12 cell assay with the highest concentrations of released GDNF (~ 341 ng/ml GDNF) inducing the highest levels of neurite extension (~556 µm). To test the cytocompatibility of aligned GDNF encapsulated PCL nanofibers, we successfully seeded neural progenitors derived from human induced pluripotent stem cells (hiPSCs) onto the scaffolds where they survived and differentiated into neurons. Overall, this research demonstrates the potential of such substrates to act as artificial dura while delivering bioactive GDNF in a controlled fashion. These scaffolds also support the culture and differentiation of hiPSC-derived neural progenitors, suggesting their biocompatibility with the cells of the central nervous system. factor (GDNF) promotes the survival of motor and dopaminergic neurons, making it a promising therapeutic for

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“…A wide range of biomaterials, both of natural and synthetic origin, are being investigated for potential applications in the spinal cord. 1–4 These materials can support endogenous tissue regeneration,5, 6 promote directed axonal growth,7, 8 enhance cell transplant survival and engraftment,9, 10 deliver drugs locally,11–13 and seal damaged dura mater 14. It is important to ensure that these materials are safe and well characterized.…”

Section: Introductionmentioning

confidence: 99%

Chitosan implants in the rat spinal cord: Biocompatibility and biodegradation

Kim

Tator

Shoichet

2011

J Biomedical Materials Res

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Biomaterials are becoming increasingly popular for use in spinal cord repair, but few studies have investigated their long-term biocompatibility in central nervous system tissue. In this study, chitosan was compared with two commercial materials, degradable polyglycolide (vicryl and polyglactin 910) and nondegradable expanded poly(tetrafluoroethylene) (Gore-Tex and ePTFE), in terms of host tissue response and biodegradation in the rat spinal cord in two different spinal cord implantation models. In an uninjured model, implants were placed in the spinal cord intrathecal space for up to 6 months. At 1 month, vicryl implants elicited an elevated macrophage/microglia response compared to chitosan and Gore-Tex, which subsided in all groups by 6 months. Fibrous encapsulation was observed for all three materials. At 6 months, the in vivo degradation of vicryl was complete, while Gore-Tex showed no signs of degradation, as assessed by mass loss and SEM. Chitosan implants showed evidence of chain degradation at 6 months as demonstrated by differential hematoxylin and eosin staining; however, this did not result in mass loss. In the second model, implants were placed directly into the spinal cord for up to 12 months. This resulted in increased immune and inflammatory responses but did not alter degradation profiles. The same trends observed for the materials in the intrathecal space were mirrored in the spinal cord tissue. These results demonstrate that chitosan is a relatively inert biomaterial that does not elicit a chronic immune response and is suitable for long-term applications for repair of the spinal cord.

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Transparent equine collagen biomatrix as dural repair. A prospective clinical study

Cited by 37 publications

References 19 publications

Dural Reconstruction in Meningioma Surgery

Dural Reconstruction in Meningioma Surgery

Development of a glial cell-derived neurotrophic factor-releasing artificial dura for neural tissue engineering applications

Chitosan implants in the rat spinal cord: Biocompatibility and biodegradation

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