“…We assume that the HD+i-SCAN colonoscope will not help to inspect the blind mucosa and therefore will not have any impact on the detection of missed lesions on the reverse side of the mucosal folds. Other recently developed ancillary techniques that may assist in detecting hidden lesions in the blind mucosal surface, such as cap-assisted, Endocuff, EndoRing, and balloon colonoscopies, work on the principle of flattening the haustral folds during withdrawal and, therefore, expanding the surface area of the colonic mucosa being visualized; the Third Eye Retroscope retrograde-viewing auxiliary device, or wider angle colonoscopes can be useful adjuncts (32)(33)(34)(35)(36). In conclusion, our study found that the use of a HD+i-SCAN colonoscope yielded an increase in flat ADR compared to a SRWL colonoscope in average-risk CRC screening colonoscopies.…”