Transparent and Robust Silica Coatings with Dual Range Porosity for Enzyme‐Based Optical Biosensing

Srivastava

ACS Biomater. Sci. Eng.

2019

115

Silica nanoparticles (Si-NPs) are widely explored in biomedical applications due to their high surface area, excellent biocompatibility, and tunable pore size. The silica surface can be readily functionalized for wide range of applications such as cellular imaging, biosensing, and targeted drug delivery. This comprehensive review discusses different synthesis methodologies of Si-NPs and their surface functionalization with various functional groups. Nanosilica functionalization methods are discussed in detail, emphasizing their suitability for targeted drug delivery, cancer therapy, bioimaging, and biosensing. The toxicity assessment of nanosilica is also critically reviewed to get a clear focus before employing them for nanomedicine.

Section: Surface Functionalization Of Si-nps For Biomedical Applicationmentioning

confidence: 99%

Section: Si-nps In Biosensingmentioning

confidence: 99%

Nanosilica: Recent Progress in Synthesis, Functionalization, Biocompatibility, and Biomedical Applications

Srivastava

ACS Biomater. Sci. Eng.

2019

115

“…Magnetic microspheres with hierarchical porosity (PFMMs) were non-conventional precursor-a novel rigid-flexible dendrimer synthes Across numerous studies, hierarchical porosity of biocatalyst supports has been shown to be crucial in influencing the biocatalyst performance [57,58,[61][62][63][64][65][66]. The advantages of hierarchical porosity are threefold: (i) small pores (micropores) provide structural integrity of the support, (ii) large pores (large meso-and macropores) allow an improved mass transfer of the substrate, (iii) while the medium-sized pores (mesopores, which are larger than the enzyme size) can result in optimal self-assembly of enzyme molecules inside the pores, resembling the degree of crowding realized in cells.…”

Section: Porosity Influence On the Biocatalyst Performancementioning

confidence: 99%

Magnetic Nanoparticle-Containing Supports as Carriers of Immobilized Enzymes: Key Factors Influencing the Biocatalyst Performance

Matveeva

Bronstein

2021

Nanomaterials

In this short review (Perspective), we identify key features of the performance of biocatalysts developed by the immobilization of enzymes on the supports containing magnetic nanoparticles (NPs), analyzing the scientific literature for the last five years. A clear advantage of magnetic supports is their easy separation due to the magnetic attraction between magnetic NPs and an external magnetic field, facilitating the biocatalyst reuse. This allows for savings of materials and energy in the biocatalytic process. Commonly, magnetic NPs are isolated from enzymes either by polymers, silica, or some other protective layer. However, in those cases when iron oxide NPs are in close proximity to the enzyme, the biocatalyst may display a fascinating behavior, allowing for synergy of the performance due to the enzyme-like properties shown in iron oxides. Another important parameter which is discussed in this review is the magnetic support porosity, especially in hierarchical porous supports. In the case of comparatively large pores, which can freely accommodate enzyme molecules without jeopardizing their conformation, the enzyme surface ordering may create an optimal crowding on the support, enhancing the biocatalytic performance. Other factors such as surface-modifying agents or special enzyme reactor designs can be also influential in the performance of magnetic NP based immobilized enzymes.

“…[18] The above research shows that using fluoropolymer to reduce surface energy and controlling surface roughness could simultaneously achieve the hydrophobicity and transparency of organic coatings, which are with potential conflict recognized as one of the most challenging issues for anti-fingerprint coating's designing. [19][20][21][22][23][24] Furthermore, fabricating micro/nano-structure is typically one of the strategies for regulating surface roughness. Cao et al fabricated porous Si films by a convenient gold-assisted electroless etching process, which possess a hierarchical porous structure consisting of micrometer-sized asperities superimposed onto a network of nanometer-sized pores.…”

mentioning

confidence: 99%

Micro/Nano‐Pores and Anti‐Fingerprint Coating by Vacancy‐Capture and Interface Intelligent Control

Luo

Hao

et al. 2023

Adv Materials Inter

Cu dewetting-masking seems limited for large-scale fabrication.The second method is the amphiphobic coating strategy since fingerprint smudging are mainly composed of water and skin oil (sebum). [15] Although the crystal structure of inorganic coatings is conducive to transparency, the chemical stability for current inorganic coatings limited their application. Thus, anti-fingerprint researches mainly focus on organic amphiphobic coatings. A thin film of polyaniline (PANI) nanofibers on the stainless steels with fluoro-thiol modification was prepared through an optimal polymerization time of aniline using HClO 4 as a dopant, showing transparent and anti-fingerprint properties. [16] Sun et al deposited silicon dioxide (SiO 2 ) onto polycarbonate (PC) substrates via the pulse laser deposition, followed by grafted trichloro(1H,1H,2H,2H-perfluorooctyl) silane (PFTS) on the silica surface. [17] Wang et al adopted vapor phase deposition technology to graft 1H,1H,2H,2H-perfluorodecyltrichlorosilane (PFDTS) onto glass surfaces modified with chitin nanofibers (ChNFs), achieving water contact angles at 156°and oil contact angles at 97°, respectively. [18] The above research shows that using fluoropolymer to reduce surface energy and controlling surface roughness could simultaneously achieve the hydrophobicity and transparency of organic coatings, which are with potential conflict recognized as one of the most challenging issues for anti-fingerprint coating's designing. [19][20][21][22][23][24] Furthermore, fabricating micro/nano-structure is typically one of the strategies for regulating surface roughness. Cao et al fabricated porous Si films by a convenient gold-assisted electroless etching process, which possess a hierarchical porous structure consisting of micrometer-sized asperities superimposed onto a network of nanometer-sized pores. [25] Bellanger et al synthesized an original series of fluorinated EDOP derivatives as monomers for the elaboration of superoleophobic surfaces by electrochemical polymerization. The authors proposed that the introduction of methylene unit between the EDOP heterocycle and the fluorinated chain turn on/off micro-to nanostructuration. [26] Caruso et al prepared porous silica films with thicknesses of 60≈130 µm and with meso-and macro-scale pores by using both porous membrane templates and amphiphilic supramolecular aggregates as pore-forming agents. [27] Kusakabe et al fabricated porous silica membranes by a sol-gel technique on a γ-aluminacoated α-alumina tube using sols from tetraethoxysilane (TEOS) and octyl-, dodecyl-or octadecyltriethoxysilane. [28] In addition,this work, a simple anti-fingerprint strategy (reduced ≈40-60%) to rearrange fingerprint droplets by patterned micro/nano-pore/spoons texture, air cushion and low surface energy is reported. Superior to previous precise and complex preparation methods, the micro/nano-texture are fabricated through conventional process of spray and dip. The pore and spoon can be freely switched by changing the process. The number (N) and size (r...