Transovarian Transmission of Hydropericardium Syndrome Virus in Experimentally Infected Poultry Birds

Tahir, Rabia; Muhammad, Khushi; Rabbani, Masood; Khan, M.U.R.; Khan, Farah; Aslam, Hassan Bin; Mehboob, Arslan

doi:10.17582/journal.hv/2017/4.6.88.91

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“…The highly pathogenic FAdV-4 serotype of broilers is naturally transmitted both vertically and horizontally ( Asthana et al., 2013 ). In the former case, FAdV-4 infection of broiler chickens prior to egg laying was most likely congenital because the virus survives in the eggs ( Tahir et al., 2017 ). In the latter case, the virus from the infected chicken is transferred to healthy flocks through the fecal-oral route because of the high shedding titer in feces ( Chandra et al., 2000 ); however, airborne and aerosol transmission of FAdV-4 is negligible.…”

Section: Physiological Features Of Fadv-4mentioning

confidence: 99%

Biological features of fowl adenovirus serotype-4

Rashid,

Xie,

Wei

et al. 2024

Front. Cell. Infect. Microbiol.

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Fowl adenovirus serotype 4 (FAdV-4) is highly pathogenic to broilers aged 3 to 5 weeks and has caused considerable economic loss in the poultry industry worldwide. FAdV-4 is the causative agent of hydropericardium-hepatitis syndrome (HHS) or hydropericardium syndrome (HPS). The virus targets mainly the liver, and HPS symptoms are observed in infected chickens. This disease was first reported in Pakistan but has now spread worldwide, and over time, various deletions in the FAdV genome and mutations in its major structural proteins have been detected. This review provides detailed information about FAdV-4 genome organization, physiological features, epidemiology, coinfection with other viruses, and host immune suppression. Moreover, we investigated the role and functions of important structural proteins in FAdV-4 pathogenesis. Finally, the potential regulatory effects of FAdV-4 infection on ncRNAs are also discussed.

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Section: Physiological Features Of Fadv-4mentioning

confidence: 99%