Transosseous application of low-intensity ultrasound for the enhancement and monitoring of fracture healing process in a sheep osteotomy model

Malizos, Konstantinos N.; Papachristos, Athanasios; Protopappas, Vasilios C.; Fotiadis, Dimitrios I.

doi:10.1016/j.bone.2005.10.012

Cited by 55 publications

(32 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Changes in both ultrasound velocity and attenuation across a healing fracture have been used to quantify fracture healing [11,19,20,28,36]. Of these two modalities of measurement (velocity and attenuation), it has been demonstrated that attenuation is by far the more sensitive to the presence of a fracture which results in a large loss in signal amplitude [14].…”

Section: Other Methods To Measure the Changes In Callus Stiffnessmentioning

confidence: 99%

Monitoring the Mechanical Properties of Healing Bone

Claes

Cunningham

2009

Clinical Orthopaedics &Amp; Related Research

125

109

View full text Add to dashboard Cite

Fracture healing is normally assessed through an interpretation of radiographs, clinical evaluation, including pain on weight bearing, and a manual assessment of the mobility of the fracture. These assessments are subjective and their accuracy in determining when a fracture has healed has been questioned. Viewed in mechanical terms, fracture healing represents a steady increase in strength and stiffness of a broken bone and it is only when these values are sufficiently high to support unrestricted weight bearing that a fracture can be said to be healed. Information on the rate of increase of the mechanical properties of a healing bone is therefore valuable in determining both the rate at which a fracture will heal and in helping to define an objective and measurable endpoint of healing. A number of techniques have been developed to quantify bone healing in mechanical terms and these are described and discussed in detail. Clinical studies, in which measurements of fracture stiffness have been used to identify a quantifiable end point of healing, compare different treatment methods, predictably determine whether a fracture will heal, and identify factors which most influence healing, are reviewed and discussed.

show abstract

Section: Other Methods To Measure the Changes In Callus Stiffnessmentioning

confidence: 99%

Monitoring the Mechanical Properties of Healing Bone

Claes

Cunningham

2009

Clinical Orthopaedics &Amp; Related Research

125

109

View full text Add to dashboard Cite

show abstract

“…3,17,18 Additionally to this, first, is the fact that bone callus is only visible on radiographic tests when fully calcified, with no image being seen before that; secondly, bone union not always involve bone callus formation, so being an almost invisible process, as occurs in shaft fractures tightly fixated and in epiphyseal and metaphyseal fractures, of endosteal union. Therefore, a resource able to be used in the early phases of union, before a bone callus is formed, and preferably one that does not involve the use of ionizing radiation would be very useful, particularly when several successive evaluations are required.…”

Section: Discussionmentioning

confidence: 99%

Estudo comparativo da velocidade e atenuação ultra-sônica na avaliação da consolidação óssea

Barbieri

Matos

et al. 2009

Acta ortop. bras.

View full text Add to dashboard Cite

Objectives: The objective of this study was to compare the in vitro ultrasonic velocity and attenuation in bone healing evaluation. Methods: Seventeen sheep weighting 37 kg in average were used, being divided into two groups of five animals each and one group of seven animals, according to the postoperative follow-up time (30, 60 and 90 days, respectively). Osteotomies were performed on the right tibiae and the intact left tibiae of the 17 animals were used as control. The healing process was monitored with conventional conventional radiographs taken at two-week intervals. The animals were sacrificed at the end of the corresponding follow-up period and both right and left tibiae were removed for in vitro underwater and contact ultrasound evaluations. The transverse and longitudinal ultrasound propagation velocity (USPV) and the broadband ultrasound attenuation (BUA) were measured and correlated. Results: USPV increased with the progression of the healing process, while BUA decreased, with significant differences between the experimental and control groups and between the experimental groups, for most of the comparisons. Conclusion: It was concluded that the method using ultrasound as employed in this investigation is feasible and reliable for evaluating cortical bone healing.

show abstract

“…Most require specialized equipment that is not available in fracture clinics and are not applicable to many common fractures or fracture treatment methods. For example, fracture stiffness [4,5,20,26] and acoustic emission [12] measurements can only be performed in those cases treated with external fixators and the fractured bone must be subcutaneous to enable testing using vibration or ultrasonic measurements [1,7,15,18,23].…”

Section: Introductionmentioning

confidence: 99%