Transoral CO2 laser treatment for Tis–T3 glottic cancer: The University of Brescia experience on 595 patients

Peretti, Giorgio; Piazza, Cesare; Cocco, Daniela; Benedetto, Luigi De; Bon, Francesca Del; Zinis, Luca Oscar Redaelli de; Nicolai, Piero

doi:10.1002/hed.21278

Cited by 183 publications

(216 citation statements)

References 21 publications

(19 reference statements)

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“…Literature concludes that TLM can be considered an established therapeutic option for selected advanced T stage laryngeal tumours, based on good oncologic, functional and economic considerations with an organ preservation rate over 60% in the vast majority of cases [4,16,55,56]. In case of laryngeal tumours involving or originating from the anterior commissure (AC), difficulties in treatment could be related to tumour exposure and technical limitations of lack of perpendicular laser tool, which could be minimised by an enlarged resection and advanced surgical experience with TLM which allow the achievement of comparable oncologic and functional results with low morbidity [24,34].…”

Section: Discussionmentioning

confidence: 99%

Conservative treatment for advanced T3–T4 laryngeal cancer: meta-analysis of key oncological outcomes

Mannelli

Lazio

Luparello

et al. 2017

Eur Arch Otorhinolaryngol

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Section: Discussionmentioning

confidence: 99%

Conservative treatment for advanced T3–T4 laryngeal cancer: meta-analysis of key oncological outcomes

Mannelli

Lazio

Luparello

et al. 2017

Eur Arch Otorhinolaryngol

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“…in contrast, both transoral robotic surgery (Tors) and transoral laser microsurgery use natural access through the oral cavity and do not damage soft tissues of the neck 4,5 . The benefits of the latter operation are well known.…”

Section: Introductionmentioning

confidence: 99%

Short-term postoperative distress associated with open vs. transoral robotic surgery (TORS) in patients with T1-T2 carcinomas of the tongue base and supraglottis

Sláma¹,

Slouka²,

Slípka³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. This study compared the adverse effects of open surgery (OS) including lateral pharyngotomy and supraglottic laryngectomy vs. transoral robotic surgery (TORS) in the treatment of stage T1 and T2 carcinomas of the tongue base and supraglottis. Methods. A retrospective study involving a 49 (13 female and 36 male) patients with untreated T1 or T2 carcinomas. Twenty two were operated on using TORS and 27 underwent conventional OS. The indicators for comparison were: total blood loss during surgery, post-operative pain measured with the Visual Analog Scale (VAS); global, emotional and physical post-operational states assessed with the standardized M.D. Anderson Dysphagia Inventory (MDADI) and psychosocial distress (PD) questionnaire. Apart from blood loss, subjective symptoms were evaluated 1 and 6 weeks and 6 months after surgery. The differences in indicators between groups were analyzed using Fisher's Least Significant Difference (LSD) test at the 5% significance level. Results. Mean general OS and TORS associated blood loss were 405 and 29 ml, respectively. The mean MDADI score in TORS vs. OS patients one week, six weeks and six months postoperatively was 60.01 vs. 44.93, 91.01 vs. 62.19 and 94.18 vs. 93.56. The mean VAS score in the TORS vs. OS group at the same time intervals were 5.09 vs. 5.56, 2.09 vs. 3.11 and 1.27 vs. 1.33. All differences between TORS and OS were statistically significant with the exception of 6 month values for particular scores. The mean PD score in TORS vs. OS patients in one week, six weeks and 6 months was 26.82 vs. 25.11, 39.95 vs. 29.22 and 44.73 vs. 44.52. Only the six week distinctions were significant. The both methods were comparable in terms of the risk of locoregional tumour recurrence. Conclusions. The study confirmed the assumption of the TORS as a minimally invasive procedure significantly reducing the intraoperative blood loss, pain, swallowing and psychosocial distress as late as 6 weeks postoperatively in patients with early staged carcinomas of the tongue base and supraglottis.

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“…Recent studies demonstrate local control with radiotherapy for T1 glottis neoplasias ranging from 82% to 93%, preserving the larynx in 89% to 96% of cases, and for T2 tumors, 57% to 82% for local control, and preservation of the larynx in 73% to 82% 30 . The rate of relapse with surgical treatment is small and depends on factors such as: involvement of the anterior commissure due to its difficult access site for adequate resection; the ideal laryngeal exposure during the surgical procedure for the various open laryngectomy techniques and for endolaryngeal or trans-oral laser resections; and conditions inherent to the patient 31 . From 1998 on, there was a change in the treatment of laryngeal cancer, with the institution of radiotherapy associated or not with chemotherapy, with the intention of preserving organs, indicated mainly for stages III (T3) 11,32 .…”

Section: Discussionmentioning

confidence: 99%

Condroradionecrose de laringe após radioterapia

Melo

Souza

Filho

et al. 2017

Rev. Col. Bras. Cir.

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RESUMO Objetivo: estudar a condroradionecrose de laringe por complicação de radio-quimioterapia para tratamento do câncer de laringe e propor um fluxograma de tratamento com a utilização de câmara hiperbárica. Métodos: estudo retrospectivo de pacientes portadores de carcinoma de laringe admitidos em dois hospitais terciários num período de cinco anos. Resultados: de 131 pacientes portadores de câncer de laringe, 28 foram submetidos à radio e quimioterapia exclusiva e destes, três evoluíram com condroradionecrose. O tratamento destes pacientes foi realizado com câmara hiperbárica e com desbridamento cirúrgico, conforme proposição do fluxograma. Todos os pacientes tiveram a laringe preservada. Conclusão: a incidência de condroradionecrose de laringe por complicação de radioterapia e quimioterapia em nossa casuística foi de 10,7% e o tratamento com oxigenoterapia hiperbárica, com base no nosso fluxograma, foi efetivo no controle desta complicação.

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Transoral CO₂ laser treatment for T_is–T₃ glottic cancer: The University of Brescia experience on 595 patients

Abstract: This series confirms the good oncologic outcomes of endoscopic laser surgery for T(is), T(1), and selected T(2) and T(3) glottic tumors.

Cited by 183 publications

References 21 publications

Conservative treatment for advanced T3–T4 laryngeal cancer: meta-analysis of key oncological outcomes

Conservative treatment for advanced T3–T4 laryngeal cancer: meta-analysis of key oncological outcomes

Short-term postoperative distress associated with open vs. transoral robotic surgery (TORS) in patients with T1-T2 carcinomas of the tongue base and supraglottis

Condroradionecrose de laringe após radioterapia

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