Transoral Carbon Dioxide Laser Ablation for Cancer, Tumors, and Other Diseases

Panje, William R.; Scher, Natan; Karnell, Michael P.

doi:10.1001/archotol.1989.01860300035012

Cited by 26 publications

(11 citation statements)

References 20 publications

(3 reference statements)

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“…Moreover, the therapeutic efficacy of the laser was found to be same for both premalignant and malignant lesions of the oral cavity. This compares well with the local control rate of 80-100% achieved by CO 2 laser for premalignant and malignant lesions of the oral cavity mentioned in the literature [2,[11][12][13], but reports of series using Nd: YAG laser exclusively for the same are scant.…”

Section: Discussionsupporting

confidence: 86%

Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Tewari

Rai

Singh

et al. 2007

Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 86%

Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Tewari

Rai

Singh

et al. 2007

Journal of Surgical Oncology

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“…Our overall success rate of 88.14% at the end of 5 years augers well with the local control rate of 80-100% achieved by CO 2 laser in premalignant and malignant lesions of the oral cavity as mentioned in specifi c literature [8,16,17]. In addition our results also match the success rate of greater than 85% reported in stage I carcinoma lip by conventional modalities of treatment [1].…”

Section: Discussionsupporting

confidence: 88%

Nd:YAG laser therapy of carcinoma lip (stage I squamous cell carcinoma): a retrospective evaluation

Singh

Tiwari

Shukla

et al. 2009

Indian J Otolaryngol Head Neck Surg

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Objective To asses the effi cacy of Nd:YAG laser for stage I squamous cell carcinoma of the lip. To the authors' knowledge this is the fi rst reported study on this subject. Study designRetrospective study design involving treatment of 46 patients of either sex of stage I squamous cell carcinoma of lip over a 10-year period in a single tertiary care university teaching hospital with Nd:YAG laser.Methods Nd:YAG laser ablation of lesions in lip was carried out in all the patients on an OPD basis with prior consent. A regular follow-up was maintained for a period of 5 years. A negative biopsy at the end of one month and one year was considered a treated case. The tabulated data was analysed statistically by "Kaplan Meier" method and "Log Rank" test. Also cosmetic and functional results were assessed by any sign of fl ow away after fi lling the oral cavity with water and postoperative integrity of facial nerve in accordance with "House Brackmann" classifi cation.Results In this series of 46 patients, 35 patients were disease free at the end of 3 years and this number further declined to 29 at the end of 5 years with 4 deaths and 2 more patients lost to follow-up. The statistical evaluation by Kaplan Meier method gives us an overall 5-year survival rate of 88.14% with a mean survival of 58 months. Further 8 patients required repeat laserization either for residual or recurrence of lesion. Also 2 patients had a lymph node metastasis during the follow-up period. Thus, by applying Kaplan Meier method recurrence-free survival (RFS) and diseasefree survival was found to be 85.1% (mean: 55 months) and 73.34% (mean: 57 months respectively. Interestingly on applying Log Rank test it was observed that the site of the lip involvement, i.e. whether upper or lower had no infl uence on disease-free survival. It was also observed that history of tobacco intake did not infl uence the disease free survival either (Log Rank Test). Moreover the cosmetic results were excellent and with no signifi cant complication observed. ConclusionThe results reported here support the use of Nd:YAG laser for treatment of Stage I squamous cell carcinoma of lip in accordance with principles of minimal invasive and morbid surgery.

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“…Precision, minimal intraoperative haemorrhage, sterilization of the surgical area, healing with minimal scarring and decreased postoperative swelling favour the use of carbon dioxide lasers for surgical treatments in the maxillofacial area 14,30 . These devices have been used for removing oral or oropharyngeal cancers, premalignant lesions, benign tumours, surgery of the temporomandibular joint or laser-assisted uvulopalatoplasty 19,20 , and for incisional and excisional biopsies in the oral cavity 20,21 , taking advantage of the inherent properties of laser to minimize blood loss and seal lymphatics and nerve endings 12 .…”

Section: Discussionmentioning

confidence: 99%

Pseudodysplastic epithelial artefacts associated with oral mucosa CO2 laser excision: an assessment of margin status

Seoane

Caballero

Urízar

et al. 2010

International Journal of Oral and Maxillofacial Surgery

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Transoral Carbon Dioxide Laser Ablation for Cancer, Tumors, and Other Diseases

Cited by 26 publications

References 20 publications

Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Nd:YAG laser therapy of carcinoma lip (stage I squamous cell carcinoma): a retrospective evaluation

Pseudodysplastic epithelial artefacts associated with oral mucosa CO2 laser excision: an assessment of margin status

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