Transmural distribution and connectivity of coronary collaterals within the human heart

Lier, Monique G.J.T.B. van; Oost, Elco; Spaan, Jos A. E.; Horssen, Pepijn van; Wal, Allard C. van der; vanBavel, Ed; Siebes, Maria; Wijngaard, Jeroen P. H. M. van den

doi:10.1016/j.carpath.2016.06.004

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…Traditional modelling of capillary beds focused on bifurcation of vessels 12 , but recently loops have been demonstrated in real capillary networks 13,14 , and we confirm that for the human radial peri-papillary capillaries 15,16 of this study. Topologically similar shunts or collaterals have been reported in heart vessel networks of older subjects 17 . Part of their role might be to reduce fluid hammer , as occurs in poorly designed water pipe networks when flows modulate abruptly.…”

Section: Introductionsupporting

confidence: 71%

“…Loops are present in all levels of the human and rodent retinal vascular beds and are important in angiogenesis 3,20,77 . As mentioned, even fairly recent models of capillary beds do not include loops 12 , but recently loops have been demonstrated in real human 3 and rat 20 retinal capillaries, chick chorioallantoic membrane capillaries 13,14 , and coronary collaterals within the human heart 17 . We certainly saw them in our samples of the human retinal RPCs (asterix in Figs 2–4).…”

Section: Discussionmentioning

confidence: 99%

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Novel morphometric analysis of higher order structure of human radial peri-papillary capillaries: relevance to retinal perfusion efficiency and age

Barbosa

Maddess

Ahn

et al. 2019

Sci Rep

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We apply novel analyses to images of superficial capillaries that are located near and around the optic disc of the human retina: the radial peri-papillary capillaries (RPCs). Due to their unique perfusion of the nerve fibre layer the RPCs are particularly significant for optic-neuropathies. The inputs to the analysis were z-stacks from 3D confocal fluorescence microscopy from 62 human retinas aged 9 to 84 years. Our aim was to find morphometric correlates of age. The retinas had no ophthalmic history. The analysis was undertaken in two stages: (1) converting the z-stacks to 3D tubular networks of vessels, and (2) characterizing the tubular networks using features derived from the Minkowski functionals (MFs). The MFs measure: the capillary volume, surface area, mean breadth, and Euler number. The mean breadth is related to tortuosity, wall shear stress and resistance to flow, and the Euler number is related to the density of loops (collaterals). Features derived from the surface area, mean breadth and Euler number were most related to age (all p ≤ 0.006). The results indicate the importance of pressure-equalizing loops and tortuosity as quantitative measures related to perfusion efficiency. The novel morphometric analysis could quantify disease-related accelerated aging and vessel malformation.

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Section: Introductionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Novel morphometric analysis of higher order structure of human radial peri-papillary capillaries: relevance to retinal perfusion efficiency and age

Barbosa

Maddess

Ahn

et al. 2019

Sci Rep

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“…As measured presently, the dysfunction occurs late in the disease course as a consequence of using coronary flow reserve, which sums flow diffusely throughout the myocardium supplied by the left anterior descending artery; whereas in HCM, the pathogenesis is initially localized [135]. Early endothelial dysfunction is further masked by the extensive collateral network within the heart that acts to preserve the metabolic, functional, and electrical integrity of the tissue [139]. After all, vascular remodeling has been observed in otherwise normal tissue.…”

Section: General Features: Histological Genetic and Metabolicmentioning

confidence: 99%

Coronary arterial vasculature in the pathophysiology of hypertrophic cardiomyopathy

Marszalek

Solaro

Wolska

2018

Pflugers Arch - Eur J Physiol

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Alterations in the coronary vascular system are likely associated with a mismatch between energy demand and energy supply and critical in triggering the cascade of events that leads to symptomatic hypertrophic cardiomyopathy. Targeting the early events, particularly vascular remodeling, may be a key approach to developing effective treatments. Improvement in our understanding of hypertrophic cardiomyopathy began with the results of early biophysical studies, proceeded to genetic analyses pinpointing the mutational origin, and now pertains to imaging of the metabolic and flow-related consequences of such mutations. Microvascular dysfunction has been an ongoing hot topic in the imaging of genetic cardiomyopathies marked by its histologically significant remodeling and has proven to be a powerful asset in determining prognosis for these patients as well as enlightening scientists on a potential pathophysiological cascade that may begin early during the developmental process. Here, we discuss questions that continue to remain on the mechanistic processes leading to microvascular dysfunction, its correlation to the morphological changes in the vessels, and its contribution to disease progression.

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“…collateral vessels both between (intercoronary) and within (intracoronary) perfusion territories of major coronary arteries 6,7 . Importantly, blood supply via well-developed collaterals can reduce the area of myocardium at risk of ischaemia, which can be detected by all myocardial perfusion imaging techniques [8][9][10] .…”

mentioning

confidence: 99%

Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia

et al. 2020

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International guidelines advocate noninvasive testing for patients with suspected ischaemia before proceeding with revascularization decision-making 1-4. Noninvasive clinical cardiac imaging continues to undergo rapid evolution, focusing on quantitative perfusion technologies for the assessment of myocardial ischaemia and coronary flow. At present, imaging of myocardial ischaemia stands at a crossroads. During a European meeting on quantitative cardiac imaging, a bench-to-bedside-to-bench perspective was used to summarize the current status and future potential of myocardial ischaemia imaging from the viewpoint of basic scientists and clinical researchers. This approach created discussions, which led to this Consensus Statement on the main advantages and disadvantages of each imaging modality, a clinical consensus on the appropriateness for specific indications and a summary of the latest developments, which together provide a framework for future quantitative imaging of myocardial ischaemia. Pathophysiology considerations The coronary circulation comprises the epicardial conductance vessels (diameter 1-6 mm) feeding an extensive network of small vessels (diameter <300-400 μm) that penetrates the cardiac muscle tissue and is the site of regulation of myocardial blood flow (MBF; Fig. 1a,b). High-resolution 3D fluorescence cryomicrotome imaging 5 has also revealed the existence of abundant small

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Transmural distribution and connectivity of coronary collaterals within the human heart

Cited by 6 publications

References 31 publications

Novel morphometric analysis of higher order structure of human radial peri-papillary capillaries: relevance to retinal perfusion efficiency and age

Novel morphometric analysis of higher order structure of human radial peri-papillary capillaries: relevance to retinal perfusion efficiency and age

Coronary arterial vasculature in the pathophysiology of hypertrophic cardiomyopathy

Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia

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