Abstract:9Background: In vitro hERG blockade assays alone provide insufficient information to accurately discriminate 10 "safe" from "dangerous" drugs. Recent studies have suggested that the integration of multiple ion channel 11 inhibition data can improve the prediction of drug-induced arrhythmogenic risks. In this study, using a family 12 of cardiac cell models representing electrophysiological heterogeneities across the ventricular wall, we 13 quantitatively evaluated transmural and rate-dependent properties of dru… Show more
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