Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofibers

Singh, Harmanpreet; Sharma, Rahul; Joshi, Munish; Garg, Tarun; Goyal, Amit K.; Rath, Goutam

doi:10.3109/21691401.2014.885442

Cited by 66 publications

(52 citation statements)

References 15 publications

(13 reference statements)

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“…SUVs were smaller than MLVs, showing size values smaller than 200 nm, which was maintained throughout the stability study (Singh et al, 2014b). Transmission electron microscopy showed spherical morphology for conventional liposomes as archaeosomes had more irregular membranes.…”

Section: Drug Delivery Systems For Natural Antioxidant Compoundsmentioning

confidence: 81%

Archaeosomes: an excellent carrier for drug and cell delivery

et al. 2015

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Archaeosomes as liposomes made with one or more ether lipids that are unique to the domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean-type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures. Archaeosomes can be produced using standard procedures (hydrated film submitted to sonication, extrusion and detergent dialysis) at any temperature in the physiological range or lower, therefore making it possible to encapsulate thermally stable compounds. Various physiological as well as environmental factors affect its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery and delivery of natural antioxidant compounds. In this review article, our major aim was to explore the applications of this new carrier system in pharmaceutical field.

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Section: Drug Delivery Systems For Natural Antioxidant Compoundsmentioning

confidence: 81%

Archaeosomes: an excellent carrier for drug and cell delivery

et al. 2015

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“…It mainly consist of connective tissues, mandatory in regulation of body temperature, oxygen, nutrients to the skin and removing toxic products (Singh et al, 2014b).…”

Section: Dermismentioning

confidence: 99%

Permeation enhancer strategies in transdermal drug delivery

et al. 2014

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Today, $74% of drugs are taken orally and are not found to be as effective as desired. To improve such characteristics, transdermal drug delivery was brought to existence. This delivery system is capable of transporting the drug or macromolecules painlessly through skin into the blood circulation at fixed rate. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive techniques of drug delivery. Several important advantages of transdermal drug delivery are prevention from hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. Human skin surface, as a site of drug application for both local and systemic effects, is the most eligible candidate available. New controlled transdermal drug delivery systems (TDDS) technologies (electrically-based, structure-based and velocity-based) have been developed and commercialized for the transdermal delivery of troublesome drugs. This review article covers most of the new active transport technologies involved in enhancing the transdermal permeation via effective drug delivery system.

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“…Disadvantages associated are: Leakage and messiness as in case of creams and gel Uncomfortable Efficacy is quite low as gels may not provide an exact dose because of non-uniformity and leakage Low retention to the vaginal epithelium Poor patient compliance Frequent administration of drug is required Prolonged duration of therapy Low bioavailability Drug release pattern is inappropriate (Parnami et al, 2013;Singh et al, 2014).…”

Section: Limitations Of Conventional Vaginal Formulationsmentioning

confidence: 99%

Advanced topical drug delivery system for the management of vaginal candidiasis

et al. 2014

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Vaginal candidiasis or vulvovaginal candidiasis (VC) is a common mucosal infection of vagina, mainly caused by Candida species. The major symptoms of VC are dyspareunia, pruritis, itching, soreness, vagina as well as vulvar erythema and edema. Most common risk factors that lead to the imbalance in the vaginal micro biota are the use of antibiotics, pregnancy, diabetes mellitus, immuno suppression as in AIDS or HIV patients, frequent sexual intercourse, spermicide and intra-uterine devices and vaginal douching. Various anti-fungal drugs are available for effective treatment of VC. Different conventional vaginal formulations (creams, gels, suppositories, powder, ointment, etc.) for VC are available today but have limited efficacy because of lesser residence time on vaginal epithelium due to self-cleansing action of vagina. So to overcome this problem, an extended and intimate contact with vaginal mucosa is desired; which can be accomplished by utilizing mucoadhesive polymers. Mucoadhesive polymers have an excellent binding capacity to mucosal tissues for considerable period of time. This unique property of these polymers significantly enhances retention time of different formulations on mucosal tissues. Currently, various novel formulations such as liposomes, nano-and microparticles, micro-emulsions, bio-adhesive gel and tablets are used to control and treat VC. In this review, we focused on current status of vaginal candidiasis, conventional and nanotechnology inspired formulation approaches.

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Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofibers

Cited by 66 publications

References 15 publications

Archaeosomes: an excellent carrier for drug and cell delivery

Archaeosomes: an excellent carrier for drug and cell delivery

Permeation enhancer strategies in transdermal drug delivery

Advanced topical drug delivery system for the management of vaginal candidiasis

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