Transmitted HIV drug resistance in antiretroviral-treatment-naive patients from Poland differs by transmission category and subtype

Parczewski, Miłosz; Leszczyszyn-Pynka, Magdalena; Witak-Jȩdra, Magdalena; Maciejewska, Katarzyna; Rymer, Weronika; Szymczak, Aleksandra; Szetela, Bartosz; Gąsiorowski, Jacek; Bociąga‐Jasik, Monika; Skwara, Paweĺ; Garlicki, Aleksander; Grzeszczuk, Anna; Rogalska, Magdalena; Jankowska, Maria A.; Lemańska, Małgorzata; Hlebowicz, Maria; Barałkiewicz, Grażyna; Mozer‐Lisewska, Iwona; Mazurek, Renata; Łojewski, Władysław; Grąbczewska, Edyta; Olczak, Anita; Jabłonowska, Elżbieta; Jw, Clark; Urbańska, Anna

doi:10.1093/jac/dku372

Cited by 15 publications

(18 citation statements)

References 35 publications

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“…These findings suggested that genotype C was the dominant strain which was resistant to ART drugs. These results, showing more TDR in subtype C and no PI or NRTI TDR in subtype B, differ from previous studies in China [6,7] and worldwide [8][9][10][11]. However, in particular, there are reasons why our results for subtype C may be different from other studies.…”

Section: Discussioncontrasting

confidence: 99%

Prevalence of transmitted drug resistance among HIV-1 treatment-naive patients in Beijing

Song

Xin

et al. 2018

Epidemiol. Infect.

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To optimise patients' outcomes and gain insight into transmitted drug resistance (TDR) among human immunodeficiency virus (HIV)-1 treatment-naive patients in Beijing, the prevalence of TDR was assessed. Demographic and clinical data of 1241 treatment-naive patients diagnosed between April 2014 and February 2015 were collected. TDR was defined using the Stanford University HIV drug resistance mutations database. The risk factors were evaluated by multi-logistic regression analysis. Among 932 successfully amplified cases, most were male (96.78%) and infected through men having sex with men (91.74%). Genotype were CRF01_AE (56.44%), B (20.60%), CRF07_BC (19.96%), C (1.61%) and other genotypes (1.39%). The overall prevalence of TDR was 6.12%. Most frequent mutations occurred in non-nucleoside reverse transcriptase inhibitors (NNRTIs) (3.11%), followed by protease inhibitors (PIs) (2.25%) and nucleoside reverse transcriptase inhibitors (NRTIs) (1.32%). Furthermore, HIV-1 genotype was associated with high risk of resistance, in which genotype C and other genotype may have higher risk for resistance. The prevalence among treatment-naive patients in Beijing was low. Resistance to NNRTIs was higher than with PIs or NRTIs. Continuous monitoring of regional levels of HIV-1 TDRs would contribute to improve treatment outcomes and prevent failures.

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Section: Discussioncontrasting

confidence: 99%

Prevalence of transmitted drug resistance among HIV-1 treatment-naive patients in Beijing

Song

Xin

et al. 2018

Epidemiol. Infect.

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“…By contrast, the CRF17_BF cluster has been characterized by HIV-1 strains resistant to both first and second NNRTIs generations, due to the presence of the RT mutations K101E and E138K [ 47 ]. These mutations are rarely found in drug-naïve HIV infected patients (prevalence: <0.4% for both non-B and B subtypes strains) [ 48 ], but were selected in a high proportion of patients receiving NNRTIs [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Recent Transmission Clustering of HIV-1 C and CRF17_BF Strains Characterized by NNRTI-Related Mutations among Newly Diagnosed Men in Central Italy

et al. 2015

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BackgroundIncreased evidence of relevant HIV-1 epidemic transmission in European countries is being reported, with an increased circulation of non-B-subtypes. Here, we present two recent HIV-1 non-B transmission clusters characterized by NNRTI-related amino-acidic mutations among newly diagnosed HIV-1 infected men, living in Rome (Central-Italy).MethodsPol and V3 sequences were available at the time of diagnosis for all individuals. Maximum-Likelihood and Bayesian phylogenetic-trees with bootstrap and Bayesian-probability supports defined transmission-clusters. HIV-1 drug-resistance and V3-tropism were also evaluated.ResultsAmong 534 new HIV-1 non-B cases, diagnosed from 2011 to 2014, in Central-Italy, 35 carried virus gathering in two distinct clusters, including 27 HIV-1 C and 8 CRF17_BF subtypes, respectively. Both clusters were centralized in Rome, and their origin was estimated to have been after 2007. All individuals within both clusters were males and 37.1% of them had been recently-infected. While C-cluster was entirely composed by Italian men-who-have-sex-with-men, with a median-age of 34 years (IQR:30–39), individuals in CRF17_BF-cluster were older, with a median-age of 51 years (IQR:48–59) and almost all reported sexual-contacts with men and women. All carried R5-tropic viruses, with evidence of atypical or resistance amino-acidic mutations related to NNRTI-drugs (K103Q in C-cluster, and K101E+E138K in CRF17_BF-cluster).ConclusionsThese two epidemiological clusters provided evidence of a strong and recent circulation of C and CRF17_BF strains in central Italy, characterized by NNRTI-related mutations among men engaging in high-risk behaviours. These findings underline the role of molecular epidemiology in identifying groups at increased risk of HIV-1 transmission, and in enhancing additional prevention efforts.

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“…The prevalence of TDR in treatment-naive individuals remains stable in most developed countries and the prevalence of acquired drug resistance is decreasing [22][23][24][25][26][27][28][29] . This implies that further transmission of HIV-1 with TDRMs is occurring in ART-naive individuals [6][7][8] .…”

Section: Drug Class Mutations Resistance Interpretationmentioning

confidence: 99%

Triple Class HIV-1 Drug Resistance in Croatia: the First Report

Planinić¹,

Oroz²,

Lepej³

2019

Rad Hrvatske akademije znanosti i umjetnosti

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Transmitted HIV drug resistance in antiretroviral-treatment-naive patients from Poland differs by transmission category and subtype

Abstract: Despite stable trends over time, patterns of t-DRMs differed notably between transmission categories and subtypes: subtype B was associated with MSM transmission and clustering while in non-B clades t-DRMs were more common and were associated with heterosexual infections.

Cited by 15 publications

References 35 publications

Prevalence of transmitted drug resistance among HIV-1 treatment-naive patients in Beijing

Prevalence of transmitted drug resistance among HIV-1 treatment-naive patients in Beijing

Recent Transmission Clustering of HIV-1 C and CRF17_BF Strains Characterized by NNRTI-Related Mutations among Newly Diagnosed Men in Central Italy

Triple Class HIV-1 Drug Resistance in Croatia: the First Report

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