Abstract:Transmission bottlenecks introduce selection pressures on HIV-1 that vary substantially with the mode of transmission. Recent studies on small cohorts have suggested that stronger selection pressures lead to fitter transmitted/founder (T/F) strains. Manifestations of this selection bias at the population level have remained elusive. Here, we analysed early CD4 cell count measurements reported from ~340,000 infected heterosexual individuals (HSX) and men-who-have-sex-with-men (MSM), across geographies, ethnicit… Show more
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