Transmission parameters of Mycobacterium avium subspecies paratuberculosis infections in a dairy herd going through a control program

Benedictus, A.; Mitchell, Rebecca; Linde-Widmann, M.; Sweeney, Raymond W.; Fyock, Terry L.; Schukken, Y.H.; Whitlock, Robert H.

doi:10.1016/j.prevetmed.2007.07.008

Cited by 76 publications

(83 citation statements)

References 16 publications

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“…MAP exposure, which leads to disease, occurs primarily in utero and/or in newborns. 2,[4][5][6][7][8][9][10][11][12] As Johne disease has become an increasingly worldwide problem, due in part to the absence of preventive vaccine/drug or curative treatments, 13 including the partially protective, MAP subunit vaccine, 14 awareness as to what role, if any, animals play in the transmission of MAP to humans is being raised. [15][16][17][18][19][20][21] This concern arises from the apparent specific association of MAP with Crohn disease, even though a role (etiology agent?)…”

Section: Introductionmentioning

confidence: 99%

“…[22][23][24] Presently, whole herd testing for risk-based management is considered by many as the best means of curtailing the spread of MAP from animal to animal, as well as farm to farm. 10,[25][26][27][28][29] However, since such practices have yet to, and most likely will not, eliminate the spread of MAP, other preventive and/or curative measures are needed. Dietzia subspecies C79793-74 was reported to inhibit growth of MAP in culture 30 similarly to a number of antimicrobioal drugs; 13 however, we anticipate that Dietzia's use as a probiotic will result in less medical complications.…”

Section: Introductionmentioning

confidence: 99%

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Assessment ofDietziasubsp.C79793-74for treatment of cattle with evidence of paratuberculosis

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Kampen

2010

Virulence

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment ofDietziasubsp.C79793-74for treatment of cattle with evidence of paratuberculosis

Click

Kampen

2010

Virulence

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“…paratuberculosis is the etiological agent of Johne's disease, or paratuberculosis, a chronic granulomatous enteritis of domestic and wild ruminants, first described in 1895 (1). Paratuberculosis is a spectral disease characterized by an extended subclinical phase of several months or years, followed by an inevitable terminal clinical stage (2). Bovine paratuberculosis is endemic to most parts of the world, including Canada (3)(4)(5), and is considered one of the most costly infectious diseases of dairy cattle (6,7).…”

mentioning

confidence: 99%

Genetic Structure of Mycobacterium avium subsp. paratuberculosis Population in Cattle Herds in Quebec as Revealed by Using a Combination of Multilocus Genomic Analyses

Sohal¹,

Arsenault²,

Labrecque³

et al. 2014

J Clin Microbiol

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c Mycobacterium avium subsp. paratuberculosis is the etiological agent of paratuberculosis, a granulomatous enteritis affecting a wide range of domestic and wild ruminants worldwide. A variety of molecular typing tools are used to distinguish M. avium subsp. paratuberculosis strains, contributing to a better understanding of M. avium subsp. paratuberculosis epidemiology. In the present study, PCR-based typing methods, including mycobacterial interspersed repetitive units/variable-number tandem repeats (MIRU-VNTR) and small sequence repeats (SSR) in addition to IS1311 PCR-restriction enzyme analysis (PCR-REA), were used to investigate the genetic heterogeneity of 200 M. avium subsp. paratuberculosis strains from dairy herds located in the province of Quebec, Canada. The majority of strains were of the "cattle type," or type II, although 3 strains were of the "bison type." A total of 38 genotypes, including a novel one, were identified using a combination of 17 genetic markers, which generated a Simpson's index of genetic diversity of 0.876. Additional analyses revealed no differences in genetic diversity between environmental and individual strains. Of note, a spatial and spatiotemporal cluster was evidenced regarding the distribution of one of the most common genotypes. The population had an overall homogeneous genetic structure, although a few strains stemmed out of the consensus cluster, including the bison-type strains. The genetic structure of M. avium subsp. paratuberculosis populations within most herds suggested intraherd dissemination and microevolution, although evidence of interherd contamination was also revealed. The level of genetic diversity obtained by combining MIRU-VNTR and SSR markers shows a promising avenue for molecular epidemiology investigations of M. avium subsp. paratuberculosis transmission patterns.

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“…Vertical transmission from dam to offspring has been described, with increasing probability if dams progress to clinical disease ). Furthermore, studies have shown horizontal transmission between calves (van Roermund et al 2007;Benedictus et al 2008). This indicates that infected animals shed quantities of bacteria early in life that are capable of transmission.…”

Section: Epidemiologymentioning

confidence: 99%

Bovine paratuberculosis: recent advances in vaccine development

Santema

Rutten

Koets

2011

Veterinary Quarterly

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Bovine paratuberculosis is a highly prevalent chronic infection of the small intestine in cattle, caused by Mycobacterium avium subspecies paratuberculosis. Current control strategies based on test-and-cull and biosecurity measures do not suffice in lowering the prevalence of paratuberculosis in an adequate manner. Therefore, control programmes are in need of an effective vaccine, but at the moment no vaccine is registered for use in cattle in the European Union. This review provides a brief overview of the microbiology, epidemiology and immunology of bovine paratuberculosis, and focuses on recent advances in the development of vaccines against paratuberculosis.

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Transmission parameters of Mycobacterium avium subspecies paratuberculosis infections in a dairy herd going through a control program

Cited by 76 publications

References 16 publications

Assessment ofDietziasubsp.C79793-74for treatment of cattle with evidence of paratuberculosis

Assessment ofDietziasubsp.C79793-74for treatment of cattle with evidence of paratuberculosis

Genetic Structure of Mycobacterium avium subsp. paratuberculosis Population in Cattle Herds in Quebec as Revealed by Using a Combination of Multilocus Genomic Analyses

Bovine paratuberculosis: recent advances in vaccine development

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