Transmission of Reagin Through the Placenta

Cohen, Milton B.; Cohen, Shlomo B.; Hawver, Kenneth

doi:10.3181/00379727-41-10716p

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1940

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“…On the other hand, many writers (in particular, Ratner (19)) maintain that reagins in human beings behave like anaphylactic antibodies, which have been shown to pass through the placenta in guinea pigs (20). Ratner's view, as well as the recent report by Cohen et al (21) on Macacus rhesus monkeys, is open to the objection that conditions in man and animal may not be the same. One way of settling this question is to make quantitative studies of the reagins in maternal and cord blood of human beings in order to see whether reagins obey the same rules as other antibodies.…”

Section: P~esultsmentioning

confidence: 99%

Permeability of the Human Placenta to Antibodies

Wiener

Silverman

1940

Journal of Experimental Medicine

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The ratio of the titers of various antibodies, namely, hemagglutinins and syphilitic reagin, in the maternal blood to that of the corresponding antibody in the cord blood was found to be relatively constant, falling somewhere between 8 and 16. This figure may be considered the "index of permeability" of human placenta to antibodies, or the coefficient of distribution of antibodies between maternal and cord blood. The possible application of these findings to the study of the placental permeability to sensitizing antibodies (or reagins) is discussed.

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Section: P~esultsmentioning

confidence: 99%