Transmission of Omicron (B.1.1.529) - SARS-CoV-2 Variant of Concern in a designated quarantine hotel for travelers: a challenge of elimination strategy of COVID-19

Wong, Shuk-Ching; Au, Albert Ka-Wing; Chen, Hong; Yuen, Lithia Lai-Ha; Li, Xin; Lung, David Christopher; Chu, Allen Wing-Ho; Ip, Jonathan Daniel; Chan, Wan-Mui; Tsoi, Hoi-Wah; To, Kelvin Kai‐Wang; Yuen, Kwok‐Yung; Cheng, Vincent Chi-Chung

doi:10.1016/j.lanwpc.2021.100360

Cited by 68 publications

(63 citation statements)

References 8 publications

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“…With these measures, there was no community outbreak of COVID-19 when the fourth wave of COVID-19 came to the end on April 2021. Despite some sporadic episodes of SARS-CoV-2 transmission in the designated quarantine hotels between quarantinees,( Wong et al, 2021 , Wong et al, 2021 ) these did not result in a new wave of COVID-19 in our community. Cheng et al, (2021) …”

Section: Introductionmentioning

confidence: 80%

Outbreak investigation of airborne transmission of Omicron (B.1.1.529) - SARS-CoV-2 variant of concern in a restaurant: Implication for enhancement of indoor air dilution

Cheng

Wong

et al. 2022

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 80%

Outbreak investigation of airborne transmission of Omicron (B.1.1.529) - SARS-CoV-2 variant of concern in a restaurant: Implication for enhancement of indoor air dilution

Cheng

Wong

et al. 2022

Journal of Hazardous Materials

Self Cite

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“…It was reported that the Omicron variant (B.1.1.529) was found in an asymptomatic, fully vaccinated traveller in a quarantined hotel in Hong Kong, China, and had been transmitted to another fully vaccinated traveller staying in a room across the corridor from the index patient, indicating transmission of this virus variant despite strict quarantine precautions ( Gu et al, 2021 ). Smoke tests in designated quarantine hotels revealed that aerosols could leak out may move to guest rooms and corridors and infectious aerosols may be inhaled when the doors of the rooms are opened ( Wong et al, 2021 ). Classical Wells-Riley model is widely used model to estimate transmission risk of airborne pathogens in indoor spaces.…”

Section: What Can Be Done In the Present Scenario?mentioning

confidence: 99%

Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

Khandia

Singhal

Alqahtani

et al. 2022

Environmental Research

237

196

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Since the appearance in the late of December 2019, SARS-CoV-2 is rapidly evolving and mutating continuously, giving rise to various variants with variable degrees of infectivity and lethality. The virus that initially appeared in China later mutated several times, wreaking havoc and claiming many lives worldwide amid the ongoing COVID-19 pandemic. After Alpha, Beta, Gamma, and Delta variants, the most recently emerged variant of concern (VOC) is the Omicron (B.1.1.529) that has evolved due to the accumulation of high numbers of mutations especially in the spike protein, raising concerns for its ability to evade from pre-existing immunity acquired through vaccination or natural infection as well as overpowering antibodies-based therapies. Several theories are on the surface to explain how the Omicron has gathered such a high number of mutations within less time. Few of them are higher mutation rates within a subgroup of population and then its introduction to a larger population, long term persistence and evolution of the virus in immune-compromised patients, and epizootic infection in animals from humans, where under different immune pressures the virus mutated and then got reintroduced to humans. Multifaceted approach including rapid diagnosis, genome analysis of emerging variants, ramping up of vaccination drives and receiving booster doses, efficacy testing of vaccines and immunotherapies against newly emerged variants, updating the available vaccines, designing of multivalent vaccines able to generate hybrid immunity, up-gradation of medical facilities and strict implementation of adequate prevention and control measures need to be given high priority to handle the on-going SARS-CoV-2 pandemic successfully.

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“…The reported case of transmission of the Omicron variant between two patients staying in different rooms in a designated quarantine hotel in Hong Kong, despite the strict quarantine precautions, is iconic [51]. This case has brought scientists to demonstrate, through a smoke test, that even a door left slightly open might cause an inward airflow that could lead to infection [52].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Omicron Genetic and Clinical Peculiarities That May Overturn SARS-CoV-2 Pandemic: A Literature Review

Tiecco

Storti

Antoni

et al. 2022

IJMS

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The Coronavirus disease 2019 (COVID-19) pandemic poses a great threat to global public health. The original wild-type strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has genetically evolved, and several variants of concern (VOC) have emerged. On 26 November 2021, a new variant named Omicron (B.1.1.529) was designated as the fifth VOC, revealing that SARS-CoV-2 has the potential to go beyond the available therapies. The high number of mutations harboured on the spike protein make Omicron highly transmissible, less responsive to several of the currently used drugs, as well as potentially able to escape immune protection elicited by both vaccines and previous infection. We reviewed the latest publication and the most recent available literature on the Omicron variant, enlightening both reasons for concern and high hopes for new therapeutic strategies.

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Transmission of Omicron (B.1.1.529) - SARS-CoV-2 Variant of Concern in a designated quarantine hotel for travelers: a challenge of elimination strategy of COVID-19

Cited by 68 publications

References 8 publications

Outbreak investigation of airborne transmission of Omicron (B.1.1.529) - SARS-CoV-2 variant of concern in a restaurant: Implication for enhancement of indoor air dilution

Outbreak investigation of airborne transmission of Omicron (B.1.1.529) - SARS-CoV-2 variant of concern in a restaurant: Implication for enhancement of indoor air dilution

Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

Omicron Genetic and Clinical Peculiarities That May Overturn SARS-CoV-2 Pandemic: A Literature Review

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