Transmission of occupational disease to family contacts

Knishkowy, Barry; Baker, Edward L.

doi:10.1002/ajim.4700090606

Cited by 68 publications

(31 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another indirect route of exposure may be by household contamination with substances brought home by the father, although this mechanism is less well documented (29).…”

Section: Discussionmentioning

confidence: 99%

Reproductive effects of paternal exposure to chlorophenate wood preservatives in the sawmill industry

Dimich‐Ward¹,

Hertzman²,

Teschke³

et al. 1996

Scand J Work Environ Health

View full text Add to dashboard Cite

Objectives The purpose of the study was to determine whether paternal occupational exposure to dioxincontaminated chlorophenols is associated with an increased risk of congenital anomalies or other adverse reproductive outcomes in offspring. Methods As a result of a multistep linkage, 19 675 births between 1952 and 1988 were identified as children of a cohort of 9512 fathers who had worked at least one year in British Columbia sawmills where chlorophenate wood preservatives had been used. A nested case-referent analysis was applied, using conditional logistic regression, with five referents matched per case according to year of birth and gender. Chlorophenate exposure was based on expert raters' estimations of hours of exposure applied to specific time windows prior to birth. Results The offspring of male sawmill workers were at increased risk for developing congenital anomalies of the eye, particularly congenital cataracts; elevated risks for developing anencephaly or spina bifida and congenital anomalies of genital organs were shown according to specific windows of exposure. No associations were found for low birthweight, prematurity, stillbirths, or neonatal deaths. C O~C~U S~O~S The study adds further support to the hypothesis of male-mediated developmental toxicity. Paternal exposure to chlorophenates was associated with the development of certain congenital anomalies in offspring.

show abstract

“…Another indirect route of exposure may be by household contamination with substances brought home by the father, although this mechanism is less well documented (29).…”

Section: Discussionmentioning

confidence: 99%

Reproductive effects of paternal exposure to chlorophenate wood preservatives in the sawmill industry

Dimich‐Ward¹,

Hertzman²,

Teschke³

et al. 1996

Scand J Work Environ Health

View full text Add to dashboard Cite

show abstract

“…This pathway involves the transport of contaminants from the workplace to the residence on a worker's clothing or person. Compounds that are likely to cling to and are difficult to remove from clothing, shoes, skin, or hair (e.g., beryllium, asbestos, lead, pesticides) are potential takehome contaminants, and the take-home pathway has been well documented for several of these compounds (Knishkowy and Baker 1986;McDiarmid and Weaver 1993;NIOSH 1995). A recent study by Lu et al (2000) indicated that the take-home pathway is a significant contributor to residential contamination in the homes of agricultural workers.…”

mentioning

confidence: 99%

Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children.

Curl

Fenske

Kissel

et al. 2002

Environ Health Perspect

262

236

View full text Add to dashboard Cite

We analyzed organophosphorus pesticide exposure in 218 farm worker households in agricultural communities in Washington State to investigate the take-home pathway of pesticide exposure and to establish baseline exposure levels for a community intervention project. House dust samples (n = 156) were collected from within the homes, and vehicle dust samples (n = 190) were collected from the vehicles used by the farm workers to commute to and from work. Urine samples were obtained from a farm worker (n = 213) and a young child (n = 211) in each household. Dust samples were analyzed for six pesticides, and urine samples were analyzed for five dialkylphosphate (DAP) metabolites. Azinphosmethyl was detected in higher concentrations (p < 0.0001) than the other pesticides: geometric mean concentrations of azinphosmethyl were 0.53 micro g/g in house dust and 0.75 micro g/g in vehicle dust. Dimethyl DAP metabolite concentrations were higher than diethyl DAP metabolite concentrations in both child and adult urine (p < 0.0001). Geometric mean dimethyl DAP concentrations were 0.13 micro mol/L in adult urine and 0.09 micro mol/L in child urine. Creatinine-adjusted geometric mean dimethyl DAP concentrations were 0.09 micro mol/g in adult urine and 0.14 micro mol/g in child urine. Azinphosmethyl concentrations in house dust and vehicle dust from the same household were significantly associated (r2 = 0.41, p < 0.0001). Dimethyl DAP levels in child and adult urine from the same household were also significantly associated (r2 = 0.18, p < 0.0001), and this association remained when the values were creatinine adjusted. The results of this work support the hypothesis that the take-home exposure pathway contributes to residential pesticide contamination in agricultural homes where young children are present.

show abstract

“…Trabalho de coorte prospectivo, realizado por Selikoff et al em isoladores térmicos norte-americanos, mostra tempo de latência entre 25 e 40 anos em 175 casos de MM 38 . Quanto ao tipo de contaminação ocorrida, podemos classificar os três casos, respectivamente, em domiciliar (caso 1), ocupacional (caso 2) e ocupacional indireto (caso 3) [39][40][41] . Apesar da ocupação relatada no caso 3 não se relacionar, etiologicamente, com MM, a freqüência quase que diária a um ambiente de trabalho contaminado por asbes-to, durante quase três anos, por motivos extraocupacionais, não anula as características ocupacionais indiretas de exposição a que se submeteu o paciente.…”

Section: Discussão E Conclusãounclassified

Mesotelioma maligno de pleura com associação etiológica a asbesto: a propósito de três casos clínicos

Capitani¹,

Metze²,

Frazato³

et al. 1997

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

RESUMO -O mesotelioma maligno de pleura (MM) é tumor de ocorrência rara em nosso meio e tem-se mostrado, quando em elevada incidência, relacionado à exposição pregressa a asbesto ou amianto nas séries descritas em outros países.OBJETIVO UNITERMOS:Mesotelioma maligno. Pleura. Asbesto. Etiologia. Diagnóstico. INTRODUÇÃOApesar de conhecido desde 1767, quando Lieutand relatou dois casos em cerca de 3.000 autó-psias 1 , a primeira descrição detalhada da patologia foi feita por Wagner, em 1870 1 . No entanto, somente neste século o mesotelioma maligno (MM) foi caracterizado como entidade nosológica especí-fica, com critérios diagnósticos bem definidos 2-4 . Apesar dos inúmeros trabalhos publicados até o momento, o MM continua sendo um tema controverso na literatura científica. Coleman et al. consideram que o assunto permaneça em ativa discussão por três motivos: a) sua estreita associação etiológica com exposição ao asbesto, trazendo implicações legais e científicas de importância no campo da pesquisa de agentes e mecanismos de ação carcinogênicos; b) o fato de o MM representar um modelo de câncer em função de sua capacidade multidirecional de diferenciação epitélio-mesenquimal; e c) a dificuldade de definição diagnóstica em vida, a partir de fragmentos pequenos de biópsia, necessitando distinção entre hiperplasia inflamatória mesotelial e neoplasias metastáticas como o adenocarcinoma 5 . Por definição, o mesotelioma é um tumor que provém das células mesoteliais multipotenciais da pleura ou peritônio. Tem caráter rápido, difuso e extenso de crescimento, envolvendo grande parte da superfície serosa afetada. Apresenta alto grau de malignidade, expresso por invasão local de partes moles, como parede torácica, parênquima pulmonar, pericárdio adjacente e linfonodos regionais. Pode produzir metástases para os pulmões, fígado, pâncreas, rins, supra-renais e medula óssea 6 , com sobrevida média não ultrapassando doze meses, independentemente do tipo de tratamento realizado 7 . Classifica-se em três tipos histopatológicos: epitelial, fibrossarcomatoso e misto ou bifásico 6,7 .

show abstract

Transmission of occupational disease to family contacts

Cited by 68 publications

References 26 publications

Reproductive effects of paternal exposure to chlorophenate wood preservatives in the sawmill industry

Reproductive effects of paternal exposure to chlorophenate wood preservatives in the sawmill industry

Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children.

Mesotelioma maligno de pleura com associação etiológica a asbesto: a propósito de três casos clínicos

Contact Info

Product

Resources

About