Transmission of novel <i>Klebsiella pneumoniae</i> carbapenemase-producing <i>Escherichia coli</i> sequence type 1193 among residents and caregivers in a community-based, residential care setting—Nevada, 2018

Gomes, Danica; Bardossy, Ana C.; Chen, Lei; Forero, Adrian; Gorzalski, Andrew; Holmstadt, Heather; Causey, Kimisha; Njoku, Chidinma; Stone, Nimalie D.; Ogundimu, Abimbola; Moulton-Meissner, Heather; McAllister, Gillian; Halpin, Alison Laufer; Gable, Paige; Vlachos, Nicholas; Larson, Sandra; Epstein, Lauren

doi:10.1017/ice.2020.279

Cited by 6 publications

(5 citation statements)

References 4 publications

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“…ST1193 is known to carry diverse plasmid cargo, including large multidrug resistance plasmids ( 6 ), and the first carbapenem nonsusceptible ST1193 isolates carrying bla NDM ( 7 ) and bla KPC ( 8 ) were reported recently. The sequence type is remarkable because it has risen to prominence in a short period of time and has been recovered from multiple hosts, including humans ( 9 , 10 ), dogs ( 11 , 12 ), synanthropic birds ( 13 , 14 ), and water sources ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Global Phylogeny and F Virulence Plasmid Carriage in Pandemic Escherichia coli ST1193

et al. 2022

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We have generated an updated ST1193 phylogeny using publicly available sequences, reinforcing previous assertions that Escherichia coli ST1193 is a human-associated lineage, with many examples sourced from human extraintestinal infections. ST1193 from urban-adapted birds, wastewater, and companion animals are frequent, but isolates from animal agriculture are notably absent.

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Section: Introductionmentioning

confidence: 99%

Global Phylogeny and F Virulence Plasmid Carriage in Pandemic Escherichia coli ST1193

et al. 2022

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“…coli ST1193 is an emerging MDR high-risk clone that belongs to the highly pathogenic B2 lineage and is resistant to fluoroquinolones while producing ESBL [10]. ST1193 is the second most commonly isolated AMR E. coli clone after ST131 [10] and has been identified in many regions worldwide, including Japan [11][12][13]. Since 2012, its global prevalence has been on the rise, and in certain regions, it has replaced ST131 [10].…”

Section: Microbiological Characteristics Of Mrsa St764 and E Coli St1193mentioning

confidence: 99%

“…E. coli ST1193 and ST131 have prolonged gut persistence (over 6 months) and high rates of bacteriuria compared with those of other E. coli clones [14]. Furthermore, E. coli ST1193 is involved in both community-associated (CA) and hospital-associated (HA) urinary tract infections (UTIs) and bloodstream infections [11,12,[15][16][17]. In addition, E. coli ST1193 has been reported to be responsible for HA-UTIs in long-term care facilities [11,12], as well as being implicated in sepsis and UTIs in children and neonates [18,19].…”

Section: Microbiological Characteristics Of Mrsa St764 and E Coli St1193mentioning

confidence: 99%

Diabetic Foot Osteomyelitis Caused by Co-Infection with Methicillin-Resistant Staphylococcus aureus and Multidrug-Resistant Extended-Spectrum ß-Lactamase-Producing Escherichia coli: A Case Report

Kitaya,

Miura,

Suzuki

et al. 2023

Applied Microbiology

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This case report describes a 47-year-old man with type 2 diabetes and its associated complications. The patient developed co-infection with methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant (MDR) extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli following surgical amputation for osteomyelitis caused by diabetic foot infection (DFI). The patient had a history of recurrent hospitalization due to DFI and had received multiple antimicrobials. Intraoperative wound cultures identified MRSA and MDR ESBL-producing E. coli as the causative agents of the co-infection. Intravenous vancomycin and meropenem were administered. After surgery, daily debridement and hyperbaric oxygen therapy were performed. The patient underwent surgical wound closure and was discharged on day 86. Polymicrobial infections in DFIs worsen antimicrobial resistance, impede wound healing, and increase the risk of osteomyelitis and amputation. Furthermore, infections caused by MDR bacteria exacerbate challenges in infection control, clinical treatment, and patient outcomes. In DFI cases caused by co-infection with MDR bacteria, prompt and appropriate antimicrobial therapy, debridement, and regular wound care while considering transmission are essential.

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“…Genomic sequencing is a critical tool in the investigation of CRE [12]. In addition to understanding molecular epidemiology, it can be used in outbreak investigations [12][13][14][15][16][17], and to identify the presence of genes of interest (e.g. known and putative carbapenemase genes [18,19] or hypervirulence markers [20]) in a bacterial isolate.…”

Section: Introductionmentioning

confidence: 99%

Comparison of carbapenem-susceptible and carbapenem-resistant Enterobacterales at nine sites in the USA, 2013–2016: a resource for antimicrobial resistance investigators

Lutgring,

Kent,

Bowers

et al. 2023

Microbial Genomics

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Carbapenem-resistant Enterobacterales (CRE) are an urgent public health threat. Genomic sequencing is an important tool for investigating CRE. Through the Division of Healthcare Quality Promotion Sentinel Surveillance system, we collected CRE and carbapenem-susceptible Enterobacterales (CSE) from nine clinical laboratories in the USA from 2013 to 2016 and analysed both phenotypic and genomic sequencing data for 680 isolates. We describe the molecular epidemiology and antimicrobial susceptibility testing (AST) data of this collection of isolates. We also performed a phenotype–genotype correlation for the carbapenems and evaluated the presence of virulence genes in Klebsiella pneumoniae complex isolates. These AST and genomic sequencing data can be used to compare and contrast CRE and CSE at these sites and serve as a resource for the antimicrobial resistance research community.

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Transmission of novel Klebsiella pneumoniae carbapenemase-producing Escherichia coli sequence type 1193 among residents and caregivers in a community-based, residential care setting—Nevada, 2018

Cited by 6 publications

References 4 publications

Global Phylogeny and F Virulence Plasmid Carriage in Pandemic Escherichia coli ST1193

Global Phylogeny and F Virulence Plasmid Carriage in Pandemic Escherichia coli ST1193

Diabetic Foot Osteomyelitis Caused by Co-Infection with Methicillin-Resistant Staphylococcus aureus and Multidrug-Resistant Extended-Spectrum ß-Lactamase-Producing Escherichia coli: A Case Report

Comparison of carbapenem-susceptible and carbapenem-resistant Enterobacterales at nine sites in the USA, 2013–2016: a resource for antimicrobial resistance investigators

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