Transmission of malaria in relation to distribution and coverage of long-lasting insecticidal nets in central Côte d’Ivoire

Ouattara, Allassane; Dagnogo, Mamadou; Constant, Edi A V; Koné, Moussa; Raso, Giovanna; Tanner, Marcel; Olliaro, Piero; Utzinger, Jürg; Koudou, Benjamin G.

doi:10.1186/1475-2875-13-109

Cited by 16 publications

(18 citation statements)

References 52 publications

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“…Protective immunity against malaria infection is acquired with age, and exposure times are key reasons for high prevalence observed in children under 5 with developing immune system which constitute true Gametocyte reservoirs regarding epidemiological chain. A study carried out in villages from the central region of Côte d'Ivoire led to similar results (Ouattara et al, 2014). Another study carried out in the central south region of the country in 2010 and 2011 presented a prevalence of 46 and 56 % respectively (Bassa et al, 2016), indicating that infection prevalence is function of period, epidemiological facies and vegetation that promote and maintain anopheles pressure (Raso et al, 2012).…”

Section: Discussionmentioning

confidence: 68%

Prevalence and genetic diversity of Plasmodium falciparum in patients attending regional health center in Daloa, Cte dIvoire

Koffi¹,

Abe²,

Ahouty³

et al. 2019

Int. J. Genet. Mol. Biol.

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Malaria is a parasitic disease defined as a major problem of public health in Côte d'Ivoire. One of the constraints of the control of this disease might be the genetic diversity of the main pathogen, Plasmodium falciparum. This study aims to evaluate the genetic diversity of Plasmodium falciparum in individuals at the regional health center in Daloa, Côte d'Ivoire. A total of 380 blood samples were collected from patients, from June to October, 2015, based on malaria clinical signs and symptoms. Whole DNA was extracted from blood samples tested positive by microscopic examination for P. falciparum. A nested PCR targeting the msp-1(block 2) allelic families was implemented for the parasite genetic diversity. The associations between malaria infection and socio-environment factors were estimated. Out of the 380 examined patients, 262 were tested positive by microscopic examination representing a prevalence of 68.95%. Genotyping from 160 sample randomly chosen allowed to identify 35 alleles comprising 13 K1, 12 Mad 20 and 10 Ro33 type. Mixed infections were significantly correlated with the parasite load. The number of parasite strains hosted by a patient was significantly linked to the level of anemia and the parasite density. The multiplicity of the infection (MOI) decreased significantly with the age. Genetic variability of strains is a very important parameter to be taken into account in the epidemiology of malaria. The present results should draw the attention of decision-makers to develop a better monitoring strategy for the elimination of malaria in an endemic country such as Côte d'Ivoire.

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Section: Discussionmentioning

confidence: 68%

Prevalence and genetic diversity of Plasmodium falciparum in patients attending regional health center in Daloa, Cte dIvoire

Koffi¹,

Abe²,

Ahouty³

et al. 2019

Int. J. Genet. Mol. Biol.

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“…A report from Côte d’Ivoire showed that ITNs remained effective in reducing entomological inoculation rate in an area of higher kdr frequency in An . gambiae mosquitoes ( 14 ). Similarly, a cohort study in Malawi found that the use of ITNs reduced the incidence of cases of malaria by 30% in children in an area that has documented moderate levels of pyrethroid resistance and considerable malaria transmission ( 15 ).…”

Section: Resultsmentioning

confidence: 99%

Pyrethroid and DDT Resistance and Organophosphate Susceptibility amongAnophelesspp. Mosquitoes, Western Kenya

Wanjala¹,

Mbugi²,

Ototo³

et al. 2015

Emerg. Infect. Dis.

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“…As the area had high perennial malaria transmission, the campaign appears to have contributed to the reduction. Reductions in the EIR following deployment of vector control interventions were observed in a number of other settings [ 3 , 29 ]. In subsequent years, an increase was observed in mosquito densities and the EIR, although values remained below the baseline figures.…”

Section: Discussionmentioning

confidence: 99%

Entomological surveillance following a long-lasting insecticidal net universal coverage campaign in Midwestern Uganda

et al. 2015

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BackgroundA universal coverage campaign (UCC) with long-lasting insecticidal nets (LLINs) was implemented in four districts in Midwestern Uganda in 2009–2010. Entomological surveys were carried out to monitor changes in vector density, behaviour and malaria transmission following this intervention.MethodsAnopheles mosquitoes were collected using CDC light traps quarterly and human landing catch twice a year in four sites. Collections were done at baseline before the campaign and over a three-year period following the campaign. Plasmodium falciparum circumsporozoite enzyme-linked immunosorbent assays were performed. A subset of anophelines were molecularly identified to species, and kdr L1014S frequencies were determined.ResultsThe prevailing malaria vector in three sites was Anopheles gambiae s.l. (>97 %), with An. funestus s.l. being present in low numbers only. An. gambiae s.s. dominated (> 95 %) over An. arabiensis within A. gambiae s.l. In the remaining site, all three vector species were observed, although their relative densities varied among seasons and years. Vector densities were low in the year following the UCC but increased over time. Vector infectivity was 3.2 % at baseline and 1.8 % three years post-distribution (p = 0.001). The daily entomological inoculation rate (EIR) in 2012 varied between 0.0-0.98 for the different sites compared to a baseline EIR that was between 0.0-5.8 in 2009. There was no indication of a change in indoor feeding times, and both An. gambiae s.l. and An. funestus s.l. continued to feed primarily after midnight with vectors being active until the early morning. Kdr L1014S frequencies were already high at baseline (53–85 %) but increased significantly in all sites over time.ConclusionsThe entomological surveys indicate that there was a reduction in transmission intensity coinciding with an increase in use of LLINs and other antimalarial interventions in areas of high malaria transmission. There was no change in feeding behaviour, and human-vector contact occurred indoors and primarily after midnight constantly throughout the study. Although the study was not designed to evaluate the effectiveness of the intervention compared to areas with no such intervention, the reduction in transmission occurred in an area with previously stable malaria, which seems to indicate a substantial contribution of the increased LLIN coverage.

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Transmission of malaria in relation to distribution and coverage of long-lasting insecticidal nets in central Côte d’Ivoire

Cited by 16 publications

References 52 publications

Prevalence and genetic diversity of Plasmodium falciparum in patients attending regional health center in Daloa, Cte dIvoire

Prevalence and genetic diversity of Plasmodium falciparum in patients attending regional health center in Daloa, Cte dIvoire

Pyrethroid and DDT Resistance and Organophosphate Susceptibility amongAnophelesspp. Mosquitoes, Western Kenya

Entomological surveillance following a long-lasting insecticidal net universal coverage campaign in Midwestern Uganda

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