Transmission of impulses from pre- to postganglionic vasoconstrictor and sudomotor neurons

Jänig, Wilfrid; Krauspe, R.; Wiedersatz, G.

doi:10.1016/0165-1838(82)90026-1

Cited by 21 publications

(19 citation statements)

References 20 publications

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“…(Bachoo et al, 1987). In vasomotor pathways no such peptide has yet been identified, but it has been sought to account for two findings: 1) ganglionic transmission that survives ganglionic blockade with both hexamethonium and atropine (Jänig et al, 1982, 1984); 2) potentiation of ongoing ganglionic transmission for tens of minutes after stimulation of a cut white ramus (Blumberg and Janig, 1983). Peptidergic actions were inferred (Jänig, 2006).…”

Section: Introductionmentioning

confidence: 99%

Chemical Coding for Cardiovascular Sympathetic Preganglionic Neurons in Rats

et al. 2010

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Cocaine and amphetamine-regulated transcript peptide (CART) is present in a subset of sympathetic preganglionic neurons in the rat. We examined the distribution of CART-immunoreactive terminals in rat stellate and superior cervical ganglia and adrenal gland and found that they surround neuropeptide Y-immunoreactive postganglionic neurons and noradrenergic chromaffin cells. The targets of CARTimmunoreactive preganglionic neurons in the stellate and superior cervical ganglia were shown to be vasoconstrictor neurons supplying muscle and skin and cardiac-projecting postganglionic neurons: they did not target non-vasoconstrictor neurons innervating salivary glands, piloerector muscle, brown fat, or adrenergic chromaffin cells. Transneuronal tracing using pseudorabies virus demonstrated that many, but not all, preganglionic neurons in the vasoconstrictor pathway to forelimb skeletal muscle were CART immunoreactive. Similarly, analysis with the confocal microscope confirmed that 70% of boutons in contact with vasoconstrictor ganglion cells contained CART, whereas 30% did not. Finally, we show that CART-immunoreactive cells represented 69% of the preganglionic neuron population expressing c-Fos after systemic hypoxia. We conclude that CART is present in most, although not all, cardiovascular preganglionic neurons but not thoracic preganglionic neurons with non-cardiovascular targets. We suggest that CART immunoreactivity may identify the postulated "accessory" preganglionic neurons, whose actions may amplify vasomotor ganglionic transmission.

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Section: Introductionmentioning

confidence: 99%

Chemical Coding for Cardiovascular Sympathetic Preganglionic Neurons in Rats

et al. 2010

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“…These effects were present in cutaneous and muscle vasoconstrictor neurons, but not in sudomotor or pilomotor neurons 6 . Other studies have also found components of sympathetic transmission to the heart 8,9 and adrenal medulla 10 that are non‐nicotinic.…”

Section: Evidence For Non‐nicotinic Ganglionic Transmissionmentioning

confidence: 89%

“…When ganglionic transmission is examined experimentally after nicotinic blockade, non‐nicotinic aspects of ganglionic transmission may be brought into prominence. Wilfrid Jänig and colleagues studied these mechanisms in a series of experiments on anaesthetized cats, starting in the late 1970s 5–7 …”

Section: Evidence For Non‐nicotinic Ganglionic Transmissionmentioning

confidence: 99%

“…found that normal 1 : 1 transmission from pre‐ to post‐ganglionic neurons was blocked by hexamethonium. However, after hexamethonium, prolonged discharges of post‐ganglionic activity could be evoked when brief trains of stimuli (typically 50 shocks in 2 s) were delivered to preganglionic axons 5,6 . To be effective, however, those stimuli had to be of a voltage sufficient to stimulate unmyelinated axons 7 .…”

Section: Evidence For Non‐nicotinic Ganglionic Transmissionmentioning

confidence: 99%

“…(Before hexamethonium, normal 1 : 1 transmission is evoked by myelinated preganglionic axons.) A variable proportion of these prolonged discharges was sensitive to atropine, implying muscarinic transmission by the acetylcholine released; usually the later components were resistant to atropine and were suggested to be peptidergic 6 …”

Section: Evidence For Non‐nicotinic Ganglionic Transmissionmentioning

confidence: 99%

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A Neglected ‘Accessory’ Vasomotor Pathway: Implications for Blood Pressure Control

McAllen

Allen

Bratton

2005

Clin Exp Pharma Physio

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1. Distinct from 'regular' sympathetic preganglionic neurons, there exists a population of 'accessory' preganglionic neurons. The latter are distinguishable by their unmyelinated axons and their different functional properties. They synapse on the same ganglion cells. 2. Ongoing sympathetic activity is driven by 'regular' preganglionic neurons. 3. 'Accessory' preganglionic neurons drive hexamethonium-resistant ganglionic transmission: part of this is muscarinic and part not (possibly peptidergic or nitrergic). 4. 'Accessory' preganglionic neurons supply cardiovascular (vasomotor, cardiac, adrenal), but apparently not other, sympathetic pathways. 5. 'Accessory' preganglionic neurons are activated by arterial chemoreceptors. 6. Brief activation of 'accessory' preganglionic neurons potentiates ongoing post-ganglionic activity for tens of minutes by an action at the ganglion. This is probably by enabling previously subthreshold excitatory post-synaptic potentials to trigger action potentials. 7. Evidence is presented that microinjections of GABA into the rostral ventrolateral medulla activate the 'accessory' pathway while inhibiting the 'regular' pathway. 8. A role for this 'accessory' pathway in the long-term control of blood pressure in health and disease is predicted, but still untested.

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Mechanisms of Autonomic Integration

North

1986

Comprehensive Physiology

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Transmission of impulses from pre- to postganglionic vasoconstrictor and sudomotor neurons

Cited by 21 publications

References 20 publications

Chemical Coding for Cardiovascular Sympathetic Preganglionic Neurons in Rats

Chemical Coding for Cardiovascular Sympathetic Preganglionic Neurons in Rats

A Neglected ‘Accessory’ Vasomotor Pathway: Implications for Blood Pressure Control

Mechanisms of Autonomic Integration

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