Transmission of Human T Cell Lymphotropic Virus Type I by
Blood Transfusion before and after Mass Screening of Sera from
Seropositive Donors

Kamihira, S; Nakasima, Sigehiro; Oyakawa, Yukinobu; Moriuti, Yukiyosi; Ichimaru, Michito; Okuda, Hiroto; Kanamura, Machiko; Oota, Takiko

doi:10.1159/000461607

Cited by 14 publications

(19 citation statements)

References 3 publications

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“…Reports received by December 31, 1787, were included in the first survey. (1 988 to 1989) In November 1988, we mailed the survey form used in the second step of the First National Survey to all 103 institutions that had reported patients in the First National Survey and to five institutions that had reported patients after De-cember 31,1987. In addition, survey forms were sent to 48 university or major medical centers that had not reported patients with HAM in the First National Survey.…”

Section: First National Ham Suwey (1 986-1 987)mentioning

confidence: 99%

Nationwide survey of HTLV‐I–associated myelopathy in Japan: Association with blood transfusion

Osame¹,

Janssen

Kubota³

et al. 1990

Annals of Neurology

242

123

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To study the epidemiology of human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Japan, we conducted two nationwide surveys between October 1986 and March 1989. A total of 710 patients with HAM (definite HAM, 589; probable HAM, 121) were reported. Of the 589 patients with definite HAM, 69% were residents of the areas with the highest prevalence HTLV-I in Japan. To determine the importance of blood transfusion in the pathogenesis of HAM/TSP, we performed a case-control study in the Kagoshima district in southern Japan. Significantly more patients with HAM reported a history of blood transfusion (26/129, or 20%) than did subjects in a health survey of the general population (41/1,290, or 3%; odds ratio = 7.7, p less than 0.001) or than did hospitalized neurological patients (6/119, or 5%; odds ratio = 4.8, p less than 0.001). Furthermore, the cumulative percentages of the intervals between blood transfusion and the onset of the symptoms of HAM fit a lognormal curve, suggesting that transfusion was an important common exposure. Blood transfusion probably transmitted HTLV-I to the patients with transfusion-associated HAM because there was a significant decrease in the number of patients with the transfusion-associated HAM who received blood after implementation of nationwide screening of blood donors in 1986 (p = 0.004). In the first 2 years, screening the blood supply in Japan appears to have decreased the number of reported patients with HAM by 16%.

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Section: First National Ham Suwey (1 986-1 987)mentioning

confidence: 99%

Nationwide survey of HTLV‐I–associated myelopathy in Japan: Association with blood transfusion

Osame¹,

Janssen

Kubota³

et al. 1990

Annals of Neurology

242

123

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“…Similarly, despite routine screening of blood for hepatitis B surface antigen (HBsAg) and antibodies to hepatitis B core antigen (anti-HBc), 5% of post-transfusion hepatitis cases continue to be attributed to Hepatitis B Virus (HBV) infection (6). Human T-cell leukemia virus (HTLV-I) and cytomegalovirus (CMV) infections have also occurred following transfusion of blood negative for anti-HTLV-I and anti-CMV, respectively (7,8). Other viral agents such as non-A, non-B hepatitis (NANB), for which specific screening assays are unavailable, are also transmitted by cellular blood products.…”

mentioning

confidence: 99%

Reduction of human immunodeficiency virus‐ infected cells from donor blood by leukocyte filtration

et al. 1989

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Several filters for leukocyte removal were evaluated in terms of their ability to reduce the cell-associated human immunodeficiency virus (HIV) load in units of blood either inoculated in vitro with lymphocytes from a chronically infected cell line or collected directly from seropositive donors. Filtration of the experimentally inoculated units of blood resulted in a 5.9 log 10 mean reduction (95% confidence interval:7.4-4.5) of tissue culture infectious units (TCIU) as assayed by end-point titration using the coculture assay. Filtration of the units of blood from anti-HIV positive donors lowered the infectivity by over 2 logs, as detected by the coculture and polymerase chain reaction (PCR) techniques. However, residual cell-associated virus was detected in the majority of experiments. Clinical studies are warranted to determine if leukocyte filtration of blood will reduce the risk of transfusion transmitted viral infections.

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“…There is a discussion about the risk of transmission of HTLV associated with the cornea transplantation 9 . About this risk, Salahuddin et.…”

Section: Resultsmentioning

confidence: 99%

Standardization of the exclusion criteria for the HTLV I and II in brazilian eye banks

Montenegro¹,

Montenegro²,

Montenegro³

et al. 2015

Revista Brasileira De Oftalmologia

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Transmission of Human T Cell Lymphotropic Virus Type I by Blood Transfusion before and after Mass Screening of Sera from Seropositive Donors

Cited by 14 publications

References 3 publications

Nationwide survey of HTLV‐I–associated myelopathy in Japan: Association with blood transfusion

Nationwide survey of HTLV‐I–associated myelopathy in Japan: Association with blood transfusion

Reduction of human immunodeficiency virus‐ infected cells from donor blood by leukocyte filtration

Standardization of the exclusion criteria for the HTLV I and II in brazilian eye banks

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