Transmission of Human T Cell Lymphotropic Virus Type I by Blood Transfusion before and after Mass Screening of Sera from Seropositive Donors

Kamihira, S; Nakasima, Sigehiro; Oyakawa, Yukinobu; Moriuti, Yukiyosi; Ichimaru, Michito; Okuda, Hiroto; Kanamura, Machiko; Oota, Takiko

doi:10.1111/j.1423-0410.1987.tb02987.x

Cited by 75 publications

(9 citation statements)

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“…21 Afterwards the USA and other European countries (France, Luxembourg, Denmark, Holland, Sweden, and Belgium) have followed Japan's example. 15 39 In Spain, a study conducted in 1995 concluded that because of the low HTLV-I seroprevalence (0.002%) and poor sensitivity of serological determinations at that time, compulsory screening in blood banks was not justified.…”

Section: Discussionmentioning

confidence: 99%

Post-transplantation HTLV-1 myelopathy in three recipients from a single donor

Imirizaldu

Gómez‐Esteban²,

Axpe³

et al. 2003

Journal of Neurology, Neurosurgery & Psychiatry

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Objectives: This paper reports for the first time three cases of infection by HTLV-I via organ transplantation; all the organs coming from the same asymptomatic infected donor. The need is considered for the implementation of compulsory screenings for HTLV antibodies on organ donors and on blood banks. Methods: The determination of antibodies for HTLV-I/II on samples of serum and cerebral spinal fluid from the patients and the donor was performed by enzyme immunoassay and western blot. Analysis of proviral DNA was performed by polymerase chain reaction. To detect changes in the sequence of aminoacids, the tax gene was sequentiated, amplified, and compared with ATK prototype stocks. Spinal cord magnetic resonance imaging, cerebral spinal fluid, and somatosensory evoked potential studies were carried out in all patients. Results: All three transplanted patients developed a myelopathy within a very short period of time. In all three patients and donor the virus belonged to the Cosmopolitan A subtype. The homology of HTLV-I sequences recovered from the patients and donor was 100% in all four cases. Proviral load was high in all three patients. The factors that certainly contributed to the infection in the first place, and the development of the disease later, were on the one hand the high proviral load and their immunosupressed condition, and on the other the virus genotype, which proved to be an aggresive variant. However, the analysis of the histocompatibility antigen showed that two of the patients carried an haplotype that has been associated with a lower risk of developing this disease. Conclusions: It is argued that, although in Spain and other European countries there is not compulsory screening for HTLV antibodies because of the studies that show a low seroprevalence, in view of the cases here reported, and to avoid the serious consequences that such infection has on transplanted patients, compulsory screenings, both on organ donors and on blood banks, should be implemented.

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Section: Discussionmentioning

confidence: 99%

Post-transplantation HTLV-1 myelopathy in three recipients from a single donor

Imirizaldu

Gómez‐Esteban²,

Axpe³

et al. 2003

Journal of Neurology, Neurosurgery & Psychiatry

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“…Approximately 12% of HTLV infections occur by blood transfusion. Unlike HIV-1, whole cell transfusion is required for transmission of the virus [90,91], with a seroconversion rate of approximately 50% [90,92]; however, the risk of transmission decreases markedly if the blood units are stored for more than six days before transfusion [91,93]. The development of HAM/TSP has been noted as early as six months after transfusion of an individual with infected blood [94].…”

Section: Viral Transmissionmentioning

confidence: 99%

Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis

Kannian

Green

2010

Viruses

114

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Human T lymphotropic viruses (HTLVs) are complex deltaretroviruses that do not contain a proto-oncogene in their genome, yet are capable of transforming primary T lymphocytes both in vitro and in vivo. There are four known strains of HTLV including HTLV type 1 (HTLV-1), HTLV-2, HTLV-3 and HTLV-4. HTLV-1 is primarily associated with adult T cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-2 is rarely pathogenic and is sporadically associated with neurological disorders. There have been no diseases associated with HTLV-3 or HTLV-4 to date. Due to the difference in the disease manifestation between HTLV-1 and HTLV-2, a clear understanding of their individual pathobiologies and the role of various viral proteins in transformation should provide insights into better prognosis and prevention strategies. In this review, we aim to summarize the data accumulated so far in the transformation and pathogenesis of HTLV-1, focusing on the viral Tax and HBZ and citing appropriate comparisons to HTLV-2.

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“…Tax is not the only HTLV-1 antigen recognised by lymphocytes, but it has a position of special importance because it is the first HTLV-1 protein to be produced, and is a powerful mitogen and antigen. 6 Antigenic stimulation Tax as antigen Proliferating CD4 + help to maintain the high provirus load…”

Section: Figure 2 Human T Lymphotropic Virus Type 1 (Htlv-1) Infectiomentioning

confidence: 99%

HTLV-1 infections

Bangham¹

2000

Journal of Clinical Pathology

107

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Human T lymphotropic virus type 1 (HTLV-1) causes disabling and fatal diseases, yet there is no vaccine, no satisfactory treatment, and no means of assessing the risk of disease or prognosis in infected people. Recent research on the molecular virology and immunology of HTLV-1 shows the importance of the host's immune response in reducing the risk of these diseases, and is beginning to explain why some HTLV-1 infected people develop serious illnesses whereas most remain healthy life long carriers of the virus. These findings might be applicable to other persistent virus infections such as human immunodeficiency virus, hepatitis B, and hepatitis C. (J Clin Pathol 2000;53:581-586)

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Transmission of Human T Cell Lymphotropic Virus Type I by Blood Transfusion before and after Mass Screening of Sera from Seropositive Donors

Cited by 75 publications

References 4 publications

Post-transplantation HTLV-1 myelopathy in three recipients from a single donor

Post-transplantation HTLV-1 myelopathy in three recipients from a single donor

Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis

HTLV-1 infections

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