Transmission of Human Papillomavirus in Heterosexual Couples

Hernandez, Brenda Y.; Wilkens, Lynne R.; Zhu, Xiaolei; Thompson, Pamela J.; McDuffie, Katharine; Shvetsov, Yurii B.; Kamemoto, Lori; Killeen, Jeffrey; Ning, Lily; Goodman, Marc T.

doi:10.3201/eid1406.070616

Cited by 94 publications

(122 citation statements)

References 16 publications

(6 reference statements)

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…Hernandez et al demonstrated that – self-collection for detection of penile HPV was preferable to clinician-collection among U.S. males [10]. CDC-funded projects in the USAPI have shown high preference for alternatives to traditional cytology based screening [11]. Nonetheless, urine based HPV testing has not been rigorously evaluated in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Acceptability and feasibility of a community based participatory research project comparing cytology and urine HPV DNA testing for cervical cancer screening in Yap, Federated States of Micronesia

Hernandez

Tareg

et al. 2017

Cancer Epidemiology

Self Cite

View full text Add to dashboard Cite

Non-invasive, self-collected sampling methods for HPV DNA detection in women, which are reliable, efficient, and acceptable have the potential to address barriers to cervical cancer screening in underserved communities, including low-middle income countries (LMIC) such as the island nation of the Federated States of Micronesia (FSM). Urine-based HPV testing has not been rigorously evaluated in clinical trials. A pilot community-based participatory randomized control research project evaluated use of urine HPV testing as a more culturally- and human resource appropriate method of cervical cancer screening in Yap State, FSM. Women participated in a cervical screening intervention using pap vs. urine test (N = 217). This manuscript described attitudes about screening feasibility and preferences. Stakeholders and women participants were interviewed (N = 23), and a survey also evaluated women’s screening preferences (N = 217). Qualitative content thematic analysis with multiple coders identified themes from interviews on acceptability and feasibility of screening tests. Women research participants were comfortable with the urine test (95%), despite limitations in some to provide samples. While 82.0% indicated that they felt comfortable with Pap smear, they also preferred a clinician (42%) to do the Pap smear, explaining that they preferred having a trained worker instead of themselves to do tests. Women want to be screened but accessibility remains a challenge. Education and training of professionals and community members alike will improve clinical skills, research capacity, knowledge of screening tests and behaviors including prioritizing HPV screening and testing.

show abstract

Section: Introductionmentioning

confidence: 99%

Acceptability and feasibility of a community based participatory research project comparing cytology and urine HPV DNA testing for cervical cancer screening in Yap, Federated States of Micronesia

Hernandez

Tareg

et al. 2017

Cancer Epidemiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Indeed, genital HPV infection prevalence is lower in men than women in most populations studied [102], and the transmission of HPV from the cervix to the male genitalia occurs with significantly greater frequency than vice versa [103]. When oral HPV infection was assessed in a group of women, men who have sex with men and heterosexual men, the highest rate of oral HPV infection acquisition was detected among heterosexual men [104], presumably because their sexual partners were more likely female.…”

Section: Introductionmentioning

confidence: 99%

The role of sexual behavior in head and neck cancer: implications for prevention and therapy

Rettig

Kiess

Fakhry

2014

Expert Review of Anticancer Therapy

View full text Add to dashboard Cite

HPV-positive oropharyngeal squamous cell carcinoma (HPV-OSCC) is associated with oral sexual behaviors. The sharp rise in incidence of HPV-OSCC in the USA has been attributed to changes in sexual norms over the past five decades, with lower age at sexual debut and higher numbers of sexual partners per individual. In addition, variations in HPV-OSCC prevalence by race, age cohort and gender may be attributable to differences in oral sexual behaviors among these groups. Oral HPV infection is the putative precursor to HPV-OSCC. Risk factors for oral HPV incidence, prevalence, clearance and persistence are crucial to understanding how, and in whom, oral HPV infection progresses to malignancy. Future investigation should focus on elucidating the natural history of oral HPV infection persistence and malignant transformation, developing effective screening tools and exploring opportunities for prevention such as vaccination and public health education.

show abstract

“…We previously observed that auto-inoculation was common, particularly in men, and included transmission of sub-clinical HPV infection from the genitals to the hands 5. In an early study, concurrent genital condyloma and oral warts were common14 underscoring the possibility of oral-genital auto-inoculation.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the ubiquitous nature of HPV infection, there is limited knowledge of the relationship of clinical and sub-clinical HPV infection occurring in different parts of the body. In a prior study of HPV transmission in heterosexual couples, we observed that auto-inoculation was common in men and included transmission of sub-clinical HPV infection between different genital sites as well as between genital and extra-genital sites of the body 5. To further examine the dynamics of HPV auto-inoculation, we examined the relationship of self-reported wart history to the acquisition of asymptomatic genital HPV infection in a cohort of adult men.…”

Section: Introductionmentioning

confidence: 99%

Genital and extra-genital warts increase the risk of asymptomatic genital human papillomavirus infection in men

Hernandez

Shvetsov

Goodman

et al. 2011

Sexually Transmitted Infections

View full text Add to dashboard Cite

Objectives To evaluate the relationship of warts in different parts of the body and the risk of asymptomatic genital human papillomavirus (HPV) infection in men. Methods We examined the relationship of self-reported genital and extra-genital warts with the subsequent acquisition of asymptomatic genital HPV infection in a cohort of 331 adult men. Participants were followed at 2-month intervals for up to 4 years. Past and current presence of warts was queried at study entry. At each visit, the external genitals were sampled for HPV DNA testing. Results Men who reported a history of genital warts, including current warts, were at increased risk of acquisition of asymptomatic HPV infection of the penis glans/corona, penis shaft and scrotum. The magnitude of these associations was greatest for HPV 6/11 infection. History of warts on the fingers, arms and trunk of the body was also associated with increased risk of genital HPV infection. Current presence of warts on the fingers and trunk specifically increased the risk of acquisition of HPV types not typically found on the genitals. Conclusions Men with a history of warts on the genitals, fingers, arms and trunk may be at increased risk for acquisition of new genital HPV infections. Warts may provide an efficient reservoir for the transmission of virions to the genitals through auto-inoculation. The potential for the spread of HPV throughout the body through auto-inoculation has important implications for prevention and control of HPV infection.

show abstract

Transmission of Human Papillomavirus in Heterosexual Couples

Abstract: Rate of transmission from penis to cervix was lower than that from cervix to penis; 13 different genotypes were sexually transmitted.

Cited by 94 publications

References 16 publications

Acceptability and feasibility of a community based participatory research project comparing cytology and urine HPV DNA testing for cervical cancer screening in Yap, Federated States of Micronesia

Acceptability and feasibility of a community based participatory research project comparing cytology and urine HPV DNA testing for cervical cancer screening in Yap, Federated States of Micronesia

The role of sexual behavior in head and neck cancer: implications for prevention and therapy

Genital and extra-genital warts increase the risk of asymptomatic genital human papillomavirus infection in men

Contact Info

Product

Resources

About