Transmission of human herpesvirus 8 by sexual activity among adults in Lagos, Nigeria

Eltom, Mohamed; Mbulaiteye, Sam M.; Dada, Abinbola J.; Whitby, Denise; Biggar, Robert J.

doi:10.1097/00002030-200212060-00014

Cited by 72 publications

(68 citation statements)

References 16 publications

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“…The result is high compared to the 31% prevalence rate reported in Lagos, Nigeria by Eltom et al, (2002). However the result agrees with 42.0% prevalence rate among commercial sex workers in western Sicily which is also regarded as an endemic area for HHV8 infection as reported by Anna et al (2000).…”

Section: Discussionsupporting

confidence: 76%

Seroprevalence of Human Herpes Virus 8 (HHV8) Infection among Commercial Sex Workers in Jos

Zakari¹,

Nimzing²,

Agabi³

et al. 2012

Bayero J. Pure App. Sci.

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A study of HHV8 seropositivity was conducted among commercial sex workers in Jos aimed at determining the prevalence in relation to history of STD, duration of prostitution, age and number of sexual partners per day. Antibodies to HHV8 were detected by enzyme linked -immunosorbent assay (ELISA) (Advanced biotechnologies Inc USA) in serum samples of 90 commercial sex workers, 41 (45%) of cases were positive for HHV8, 15 (17%) of the women were HIV Seropositive. Furthermore eight (8) among the HHV8 seropositive women were HIV seropositive given a co-infection rate of 20%. Of the risk factors evaluated, HIV seropositivity and history of sexually transmitted diseases were found to be significantly associated with HHV8 infection using chi's square.( P < 0.05). However lack of condom use, number of sex partners and duration of prostitution were found not to be significantly associated with HHV8 infection using chi's square. (P > 0.05.) we expect that this important seroepidemiologic baseline data will become a powerful tool for evaluating interventions and control measures.

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Section: Discussionsupporting

confidence: 76%

Seroprevalence of Human Herpes Virus 8 (HHV8) Infection among Commercial Sex Workers in Jos

Zakari¹,

Nimzing²,

Agabi³

et al. 2012

Bayero J. Pure App. Sci.

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show abstract

“…Another report [Eltom et al, 2002] comparing HHV-8 seropositivity to sexually transmitted diseases could not find a relationship between HHV-8 and HSV-2 infection. However, in this study, seroprevalence to HHV-8 was basically evaluated by the presence of antibodies to lytic antigens.…”

Section: Discussionmentioning

confidence: 87%

Correlates of human herpes virus‐8 and herpes simplex virus type 2 infections in Northern Cameroon

Volpi

Sarmati

Suligoi

et al. 2004

Journal of Medical Virology

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The association between sexual activity and human herpes virus-8 (HHV-8) infection has been established, but the mode of acquisition is still unclear. Blood samples from 238 individuals from Northern Cameroon were tested to evaluate the incidence of herpes simplex virus-2 (HSV-2), human immunodeficiency virus (HIV), Treponema pallidum, and HHV-8 infections and to identify their possible association. The presence of HSV-2 antibodies was associated significantly with gender, age, and HIV, HHV-8 antilatent, and T. pallidum antibodies, but not with HHV-8 antilytic antibodies. In a multivariate model older age, female gender, seropositivity for HIV, for HHV-8 latent antigens and for T. pallidum were associated independently with seropositivity for HSV-2. HSV-2-seropositive individuals had significantly higher titers of antibodies to both lytic (P = 0.019) and latent (P = 0.021) HHV-8 antigens. These results suggest that HSV-2 infection can contribute to sexual transmission of HHV-8 infection.

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“…Since 1995 NHL incidence among males has decreased somewhat, reflecting the decline in the number of HIV positive individuals developing AIDS and the improved immune status of those with AIDS resulting from the introduction of highly active anti-retroviral therapy (HAART). However, available data suggest that the non-AIDS-related NHL incidence rates have continued to increase, specifically the rates among females, older males, and blacks (Eltom et al, 2002).…”

Section: Trends In Nhl Incidencementioning

confidence: 99%

The epidemiology of non-Hodgkin's lymphoma

2004

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The incidence of non-Hodgkin's lymphoma (NHL) has doubled over the past two decades in the US and most other westernized countries. While improved cancer reporting, changes in lymphoma classification, and increases in AIDS-associated lymphomas have contributed to the startling escalation of disease incidence, these factors are estimated to account for only about 50% of the increase in observed incidence. The elucidation of etiologic factors and their mechanistic role in the pathogenesis of this malignancy are critical to advancements in disease prevention and treatment. Current evidence suggests that factors/conditions that precipitate either chronic antigenic stimulation or immunosuppression may provide a preferential milieu for development of NHL. High rates of lymphoma have been observed among individuals with autoimmune disease, organ transplants, and primary or acquired immunodeficiencies. Ultraviolet radiation, previously demonstrated to have an immunosuppressive effect, has also been suggested as a possible risk factor for NHL. Several pathogens have been linked to the risk of lymphoma, including Epstein-Barr virus, human immunodeficiency virus, human T-cell lymphotropic virus-1, Helicobacter pylori, hepatitis C, and simian virus 40. Whether these microbes are responsible for specific genetic mutations that initiate tumor growth, antigenic stimulation leading to B-cell proliferation, and increased potential of random cell replication errors, or immunosuppression, which thereby promotes tumor growth, has not been clearly delineated. Other exogenous factors which have been implicated in lymphomagenesis are chemicals and agricultural exposures, hair dyes, and blood transfusions. We must build on our current knowledge regarding the etiology of NHL in order that prevention, treatment, and ultimately, cure of this malignancy becomes a reality.

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Transmission of human herpesvirus 8 by sexual activity among adults in Lagos, Nigeria

Abstract: The higher prevalence of HHV-8 antibody in groups with multiple sexual partners and the association with STD among individuals both support the sexual transmission of HHV-8 in African adults.

Cited by 72 publications

References 16 publications

Seroprevalence of Human Herpes Virus 8 (HHV8) Infection among Commercial Sex Workers in Jos

Seroprevalence of Human Herpes Virus 8 (HHV8) Infection among Commercial Sex Workers in Jos

Correlates of human herpes virus‐8 and herpes simplex virus type 2 infections in Northern Cameroon

The epidemiology of non-Hodgkin's lymphoma

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