Transmission of feline spongiform encephalopathy to mice

Variant CJD

“…1) whereas Prnp-b mice (VM) show peaks in the dorsal medulla, superior colliculus, thalamus, and septum. 2 This BSE signature was confirmed in a number of cases of BSE and was observed in a number of similar transmissions from cats, 3 kudu, and nyala.…”

Prion transmission

“…2 One of the most important developments in prion diseases is the recognition that the BSE agent, a prion disease of cattle, can infect multiple species including cats, goats and humans via the food chain. [3][4][5] In humans, BSE is known to be the causal agent of variant CJD (vCJD), a prion disorder with a novel human pathology. 3 This description of a newly emerging prion disease that is zoonotic completely revolutionized the paradigm of a prion disease being specific to a single *Correspondence to: Kevin C. Gough; Email: kevin.gough@nottingham.ac.uk Submitted: 09/17/10; Accepted: 09/17/10 Previously published online: www.landesbioscience.com/journals/prion/article/13678 DOI: 10.4161/pri.…”

Molecular Analysis of Cases of Italian Sheep Scrapie and Comparison with Cases of Bovine Spongiform Encephalopathy (BSE) and Experimental BSE in Sheep

“…Different lines of evidence suggest that BSE has been accidentally transmitted to other species, including humans (5,10,18,20). Concerns have been raised about the possibility that the BSE agent could have also infected small ruminant populations via contaminated meat and bone meal and that sheepand goat-derived products might therefore represent a risk for consumers.…”