Transmission of DNA damage and increasing reprotoxic effects over two generations of Daphnia magna exposed to uranium

Plaire, Delphine; Bourdineaud, Jean‐Paul; Alonzo, Antoine; Camilleri, Virginie; Garcia‐Sanchez, L.; Adam-Guillermin, Christelle; Alonzo, Frédéric

doi:10.1016/j.cbpc.2013.09.001

Cited by 27 publications

(28 citation statements)

References 43 publications

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“…Such an increase in sensitivity to uranium has also been measured on Daphnia magna with an increase in DNA damages and in the severity of effects on life history traits across the generations. 54,55 This general pattern in the MGU may suggest that the energy allocation shifted in this population toward individuals with a longer body-size and a lower resistance to the uranium.…”

Section: ■ Discussionmentioning

confidence: 94%

Transgenerational Adaptation to Pollution Changes Energy Allocation in Populations of Nematodes

Goussen

Péry

Bonzom

et al. 2015

Environ. Sci. Technol.

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Assessing the evolutionary responses of long-term exposed populations requires multigeneration ecotoxicity tests. However, the analysis of the data from these tests is not straightforward. Mechanistic models allow the in-depth analysis of the variation of physiological traits over many generations, by quantifying the trend of the physiological and toxicological parameters of the model. In the present study, a bioenergetic mechanistic model has been used to assess the evolution of two populations of the nematode Caenorhabditis elegans in control conditions or exposed to uranium. This evolutionary pressure resulted in a brood size reduction of 60%. We showed an adaptation of individuals of both populations to experimental conditions (increase of maximal length, decrease of growth rate, decrease of brood size, and decrease of the elimination rate). In addition, differential evolution was also highlighted between the two populations once the maternal effects had been diminished after several generations. Thus, individuals that were greater in maximal length, but with apparently a greater sensitivity to uranium were selected in the uranium population. In this study, we showed that this bioenergetics mechanistic modeling approach provided a precise, certain, and powerful analysis of the life strategy of C. elegans populations exposed to heavy metals resulting in an evolutionary pressure across successive generations.

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Section: ■ Discussionmentioning

confidence: 94%

Transgenerational Adaptation to Pollution Changes Energy Allocation in Populations of Nematodes

Goussen

Péry

Bonzom

et al. 2015

Environ. Sci. Technol.

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“…The available literature within the crustacean subphylum suggests the presence of effects over multiple generations (Alonzo et al, 2008a;Plaire et al, 2013;Massarin et al, 2010;Parisot et al, 2015;Sarapultseva & Gorski, 2013). Alonzo et al, (2008a) and Massarin et al, (2010) recorded an increase in the magnitude of deleterious effects across generations in Daphnia magna exposed to chronic alpha irradiation and chronic waterborne uranium exposure respectively, with severe impacts to fitness and reproduction in individuals of the F 2 generation.…”

Section: The Effect Of Ionising Radiation On Reproduction In Crustaceansmentioning

confidence: 94%

“…The authors (Parisot et al, 2015) hypothesised that a cumulative radiation dose may be necessary to elicit compensatory mechanisms such as DNA repair, accounting for the differential radiosensitivity between generations. Studies of radionuclide exposed daphnids using RAPD-PCR methods have indicated transmission of DNA damage from adult female daphnids to progeny across generations (Parisot et al, 2015;Plaire et al, 2013). This may be mediated by an epigenetic mechanism, as has been proposed for the transmission of effects in D. magna exposed to a range of chemical toxicants (Vandegehuchte et al, 2010) causing alterations to gene expression across generations.…”

Section: The Effect Of Ionising Radiation On Reproduction In Crustaceansmentioning

confidence: 97%

The biological effects of ionising radiation on Crustaceans: A review

et al. 2015

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Historic approaches to radiation protection are founded on the conjecture that measures to safeguard humans are adequate to protect non-human organisms. This view is disparate with other toxicants wherein well-developed frameworks exist to minimise exposure of biota. Significant data gaps for many organisms, coupled with high profile nuclear incidents such as Chernobyl and Fukushima, have prompted the re-evaluation of our approach toward environmental radioprotection. Elucidating the impacts of radiation on biota has been identified as priority area for future research within both scientific and regulatory communities. The crustaceans are ubiquitous in aquatic ecosystems, comprising greater than 66,000 species of ecological and commercial importance. This paper aims to assess the available literature of radiation-induced effects within this subphylum and identify knowledge gaps. A literature search was conducted pertaining to radiation effects on four endpoints as stipulated by a number of regulatory bodies: mortality, morbidity, reproduction and mutation. A major finding of this review was the paucity of data regarding the effects of environmentally relevant radiation doses on crustacean biology. Extremely few studies utilising chronic exposure durations or wild populations were found across all four endpoints. The dose levels at which effects occur was found to vary by orders of magnitude thus presenting difficulties in developing phyla-specific benchmark values and reference levels for radioprotection. Based on the limited data, mutation was found to be the most sensitive endpoint of radiation exposure, with mortality the least sensitive. Current phyla-specific dose levels and limits proposed by major regulatory bodies were found to be inadequate to protect species across a range of endpoints including morbidity, mutation and reproduction and examples are discussed within. These findings serve to prioritise areas for future research that will significantly advance understanding of radiation-induced effects in aquatic invertebrates and consequently enhance ability to predict the impacts of radioactive releases on the environment.

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“…This technique has been used to detect signs of genotoxicity from various contaminants, including non-essential metals, such as cadmium, boron, arsenic, mercury, nickel, and aluminum [15][16][17][18][19], and essential metals, such as zinc, sodium, manganese, and copper [6,7,9,[20][21][22]. RAPD has also been used to demonstrate the genotoxicity of various physical compounds, such as UV A and B [8] and gamma rays [23], the radioactivity of uranium and tritium [24,25] and emergent pollutant nanoparticles, such as ZnO and CuO [26]. The genotoxicity of organic compounds, such as drugs [27,29] or herbicides [11,[30][31][32] has also been largely studied.…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity assessment of pesticides on terrestrial snail embryos by analysis of random amplified polymorphic DNA profiles

Baurand

Capelli

Vaufleury

2015

Journal of Hazardous Materials

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Transmission of DNA damage and increasing reprotoxic effects over two generations of Daphnia magna exposed to uranium

Cited by 27 publications

References 43 publications

Transgenerational Adaptation to Pollution Changes Energy Allocation in Populations of Nematodes

Transgenerational Adaptation to Pollution Changes Energy Allocation in Populations of Nematodes

The biological effects of ionising radiation on Crustaceans: A review

Genotoxicity assessment of pesticides on terrestrial snail embryos by analysis of random amplified polymorphic DNA profiles

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