2017
DOI: 10.1007/s00705-017-3485-z
|View full text |Cite
|
Sign up to set email alerts
|

Transmission network characteristics based on env and gag sequences from MSM during acute HIV-1 infection in Beijing, China

Abstract: Molecular epidemiology can be used to identify human immunodeficiency virus (HIV) transmission clusters, usually using pol sequence for analysis. In the present study, we explored appropriate parameters to construct a simple network using HIV env and gag sequences instead of pol sequences for constructing a phylogenetic tree and a genetic transmission subnetwork, which were used to identify individuals with many potential transmission links and to explore the evolutionary dynamics of the virus among men who ha… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
24
0

Year Published

2018
2018
2021
2021

Publication Types

Select...
7
1

Relationship

2
6

Authors

Journals

citations
Cited by 27 publications
(25 citation statements)
references
References 25 publications
1
24
0
Order By: Relevance
“…To date, many studies based on transmission network analysis have been implemented. Zhang et al [22] constructed a transmission network to identify individuals with many potential transmission links and to explore the evolutionary dynamics of the virus among men who have sex with men (MSM) in Beijing. Zhang et al [23] demonstrated that cross-regional HIV transmission in MSM was common and identified a key region for HIV transmission by using a transmission network.…”
Section: Discussionmentioning
confidence: 99%
“…To date, many studies based on transmission network analysis have been implemented. Zhang et al [22] constructed a transmission network to identify individuals with many potential transmission links and to explore the evolutionary dynamics of the virus among men who have sex with men (MSM) in Beijing. Zhang et al [23] demonstrated that cross-regional HIV transmission in MSM was common and identified a key region for HIV transmission by using a transmission network.…”
Section: Discussionmentioning
confidence: 99%
“…The envelope glycoprotein (encoded by env ) mediates viral entry into host cells, and though it is partially shielded by glycans from the immune response, it possesses the highest genetic diversity and evolutionary rate of any gene in the HIV‐1 genome . Understanding env ‐based networks may yield insight into viral pathogenesis, for a strain that has a high degree of connectivity may possess some advantage with respect to infectivity or fitness . Translated to approaches for vaccine design in which the HIV‐1 envelope glycoprotein is a target, trends in env ‐based transmission networks could provide more contemporaneous data to show that current vaccine candidates may still cover the majority of circulating subtypes despite increasing diversity and recombination, and could also inform selection for vaccines in the pipeline.…”
Section: Discussionmentioning
confidence: 99%
“…Numerous phylogenetic studies have revealed the origins and routes of transmission of major HIV subtypes prevalent in China [51][52][53][54][55][56][57][58]. In recent years, some Chinese scholars have also used genetic surveillance or drug-resistance testing data to construct national or regional molecular networks for major HIV subtypes in China with both the above two approaches; these studies were the first attempts and explorations of molecular networks and transmission networks [59][60][61][62][63]. The 4th National HIV Molecular Epidemiological Survey revealed a full picture of the main epidemic clusters among different high-risk populations.…”
Section: Molecular Network Reconstruct the History Of Hiv Spreadmentioning
confidence: 99%